ACETAZOLAMIDE

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Trade Names:	ACETAZOLAMIDE DIAMOX
Synonyms:	Acetamox Acetazolamide Acetazolamidum Atenezo Defiltran Diamox Diamox sr Didoc Diuriwas Donmox Edemox Eytazox Glaupax L 579486 Nephramide NSC-145177 Phonurit
Status:	Approved (1953)
Entry Type:	Small molecule
Molecule Category:	Parent
ATC:	S01EC01
UNII:	O3FX965V0I


InChI Key	BZKPWHYZMXOIDC-UHFFFAOYSA-N
Smile	CC(=O)Nc1nnc(S(N)(=O)=O)s1
InChI	InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)

Action	Mechanism of Action	Reference
INHIBITOR	Carbonic anhydrase II inhibitor	PubMed

	Primary Target
carbonic anhydrase 7

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	21000	88
Enzyme Lyase	-	3-8300	3-46	0-74000	13-100
Enzyme	-	3-8300	3-46	0-74000	13-100
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	85

Mesh Heading	Maximum Phase	Mesh ID	Reference
Heart Failure	4	D006333	ClinicalTrials
Pseudotumor Cerebri	3	D011559	ClinicalTrials
Hydrocephalus, Normal Pressure	3	D006850	ClinicalTrials
Carcinoma, Hepatocellular	3	D006528	ClinicalTrials
Apnea	3	D001049	ClinicalTrials
Status Epilepticus	2	D013226	ClinicalTrials
Chronic Pain	2	D059350	ClinicalTrials
Helicobacter Infections	2	D016481	ClinicalTrials
Stroke	2	D020521	ClinicalTrials
Cysticercosis	2	D003551	ClinicalTrials
Landau-Kleffner Syndrome	2	D018887	ClinicalTrials
Sleep Apnea, Obstructive	2	D020181	ClinicalTrials
Kidney Diseases	2	D007674	ClinicalTrials
Macular Edema	2	D008269	ClinicalTrials
Hypertension, Pulmonary	2	D006976	ClinicalTrials
Multiple Sclerosis	2	D009103	ClinicalTrials
Schizophrenia	1	D012559	ClinicalTrials
Small Cell Lung Carcinoma	1	D055752	ClinicalTrials
Andersen Syndrome	1	D050030	ClinicalTrials
Hypotension, Orthostatic	1	D007024	ClinicalTrials

Salt

System Organ Classification (SOC)

	Relative Frequency (%)
Nervous system disorders	15.62
General disorders and administration site conditions	13.21
Injury, poisoning and procedural complications	11.43
Eye disorders	7.44
Gastrointestinal disorders	7.1
Musculoskeletal and connective tissue disorders	6.55
Psychiatric disorders	5.27
Skin and subcutaneous tissue disorders	4.48
Vascular disorders	4.04
Renal and urinary disorders	3.99
Investigations	3.45
Metabolism and nutrition disorders	3.4
Cardiac disorders	3.06
Respiratory, thoracic and mediastinal disorders	2.91
Immune system disorders	2.56

CONTENTS


Active Pharmaceutical Ingredients (APIs) Scaffolds	Exact Similarity SubStructure	Threshold (%) >= 70