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Total: 29
Small molecule
Approved
GASTROINTESTINAL; OTHER
ORAL
Amyotrophic Lateral Sclerosis; Anxiety Disorders; Pulmonary Disease, Chronic Obstructive; Breast Carcinoma In Situ; Endometrial Neoplasms; Dermatitis, Atopic; Gastrointestinal Hemorrhage; Hemorrhage; Ulcer; Duodenal Ulcer; Gastroesophageal Reflux; Heartburn; Peptic Ulcer
Histamine H2 receptor antagonist
Small molecule
Approved
CARDIOVASCULAR; GASTROINTESTINAL; OTHER
INJECTION; INTRA-ANAL; SUBLINGUAL; TRANSDERMAL
Colorectal Neoplasms; Hypotension; Peripheral Arterial Disease; Hypertension, Pulmonary; Infections; Inflammation; Phlebitis; Rectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Diabetic Neuropathies; Erectile Dysfunction; Hot Flashes; Lung Neoplasms; Shock; Tendinopathy; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Muscle Cramp; Myocardial Ischemia; Osteoporosis; Raynaud Disease; Reperfusion Injury; Scleroderma, Localized; Stroke; Wounds and Injuries; Angina Pectoris; Angina, Stable; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Heart Failure; Hemorrhoids; Hypertension; Myocardial Infarction; Pain
Soluble guanylate cyclase activator
Small molecule
Approved
GASTROINTESTINAL
ORAL
Carcinoma, Medullary; Esophagitis, Peptic; Hypotension, Orthostatic; Immune System Diseases; Neoplasms; Breast Carcinoma In Situ; Breast Neoplasms; Carcinoma, Renal Cell; Helicobacter Infections; Job Syndrome; Leukemia, T-Cell; Postpartum Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Barrett Esophagus; Cough; Multiple Myeloma; Multiple Sclerosis; Stomach Ulcer; Gastroesophageal Reflux; Peptic Ulcer
Histamine H2 receptor antagonist
Small molecule
Approved
GASTROINTESTINAL; IMMUNE SYSTEM; OTHER
INHALATION; ORAL
Breast Neoplasms; Neoplasms; Diabetes Mellitus, Type 1; Encephalitis, Japanese; Hemorrhagic Fever with Renal Syndrome; Hepatitis D; Influenza, Human; Lassa Fever; Leukemia, Myeloid, Acute; Thrombocytopenia; Depressive Disorder; Hepatitis; Hepatitis B, Chronic; Hepatitis C; HIV Infections; Infections; Respiratory Syncytial Virus Infections; Severe Acute Respiratory Syndrome; Fibrosis; Hepatitis C, Chronic; Liver Cirrhosis; Virus Diseases
Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor
Small molecule
Approved
GASTROINTESTINAL; OTHER
ORAL; RECTAL
Berylliosis; HIV Infections; Malnutrition; Adenoma; Colitis; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Diverticulum, Colon; Colitis, Collagenous; Colitis, Lymphocytic; Crohn Disease; Diverticular Diseases; Diverticulitis; Irritable Bowel Syndrome; Colitis, Ulcerative; Proctitis
Arachidonate 5-lipoxygenase inhibitor
Small molecule
Approved
GASTROINTESTINAL; OTHER; RESPIRATORY
INJECTION; ORAL; OTIC
Hepatitis, Alcoholic; Liver Cirrhosis, Alcoholic; Osteomyelitis; Rhinoscleroma; Carcinoma, Pancreatic Ductal; Diabetic Foot; Escherichia coli Infections; Hearing Loss; Hepatitis C; Leukemia, Myeloid, Acute; Lung Diseases; Lymphoma; Neoplasms; Periapical Periodontitis; Pseudomonas Infections; Purpura, Thrombocytopenic, Idiopathic; Amyotrophic Lateral Sclerosis; Anthrax; Cataract; Crohn Disease; Cystic Fibrosis; Leukemia, Lymphocytic, Chronic, B-Cell; Plague; Abscess; Breast Neoplasms; Bronchiectasis; Communicable Diseases; Diarrhea; Digestive System Diseases; Fever; Liver Abscess; Neutropenia; Otitis Media; Peritonitis; Pneumonia; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Sepsis; Urinary Bladder Neoplasms; Urolithiasis; Bacterial Infections; Bronchitis, Chronic; Cystitis; Eye Infections; Gonorrhea; Infections; Intraabdominal Infections; Otitis Externa; Prostatitis; Pyelonephritis; Sinusitis; Typhoid Fever; Urinary Tract Infections
Bacterial DNA gyrase inhibitor
Small molecule
Approved
GASTROINTESTINAL; OTHER
ORAL
Pancreatic Neoplasms; Alzheimer Disease; Anemia; Arthritis, Rheumatoid; Carcinoma, Medullary; Central Serous Chorioretinopathy; Child Development Disorders, Pervasive; Chronic Pain; Clostridium Infections; Colitis, Ulcerative; Communicable Diseases; Crohn Disease; Dermatitis, Atopic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Erectile Dysfunction; Glaucoma; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Laryngomalacia; Melanoma; Mitochondrial Diseases; Muscular Atrophy, Spinal; Neoplasms; Psoriasis; Pulmonary Disease, Chronic Obstructive; Breast Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Cystic Fibrosis; Gastrinoma; Granuloma; Head and Neck Neoplasms; Idiopathic Pulmonary Fibrosis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Prostatic Neoplasms, Castration-Resistant; Squamous Cell Carcinoma of Head and Neck; Squamous Intraepithelial Lesions; Ulcer; Zollinger-Ellison Syndrome; Barrett Esophagus; Cough; Cysticercosis; Diabetes Mellitus, Type 1; Dyspepsia; Esophagitis, Peptic; Exocrine Pancreatic Insufficiency; Gastrointestinal Hemorrhage; Helicobacter Infections; Hemorrhage; Multiple Sclerosis, Relapsing-Remitting; Osteoarthritis; Pain; Spondylitis, Ankylosing; Stomach Neoplasms; Wounds and Injuries; Duodenal Ulcer; Esophagitis; Gastroesophageal Reflux; Heartburn; Infections; Peptic Ulcer; Stomach Ulcer
Potassium-transporting ATPase inhibitor
Small molecule
Approved
EMERGENCY MEDICINE; GASTROINTESTINAL; OTHER
INJECTION; ORAL
Dyspnea; Brain Diseases; Brain Injuries; Lecithin Cholesterol Acyltransferase Deficiency; Neuralgia; Opioid-Related Disorders; Amphetamine-Related Disorders; Breast Neoplasms; Cholecystitis; Cocaine-Related Disorders; Glioma; Hallucinations; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Obsessive-Compulsive Disorder; Pancreatic Neoplasms; Sarcoma; Tobacco Use Disorder; Tonsillitis; Alcoholism; Gastroenteritis; Genital Neoplasms, Female; HIV Infections; Hypotension; Irritable Bowel Syndrome; Pain; Schizophrenia; Uterine Cervical Neoplasms; Vomiting; Nausea; Neoplasms; Postoperative Nausea and Vomiting
Serotonin 3a (5-HT3a) receptor antagonist
Small molecule
Approved
GASTROINTESTINAL; OTHER; RESPIRATORY
INHALATION; NASAL; ORAL; RECTAL
Cholangitis, Sclerosing; Snoring; Aspergillosis, Allergic Bronchopulmonary; Breast Neoplasms; Bronchiolitis Obliterans; Diarrhea; Esophageal Stenosis; Glomerulonephritis, IGA; Hepatitis, Autoimmune; Hypersensitivity; Lung Neoplasms; Malnutrition; Melanoma; Nasal Polyps; Radiation Pneumonitis; Respiratory Distress Syndrome; Status Asthmaticus; Altitude Sickness; Bronchopulmonary Dysplasia; Colitis, Collagenous; Colitis, Lymphocytic; Colitis, Microscopic; Eosinophilic Esophagitis; Graft vs Host Disease; Liver Cirrhosis, Biliary; Proctitis; Proctocolitis; Respiratory Tract Diseases; Severe Acute Respiratory Syndrome; Sinusitis; Sleep Apnea, Obstructive; Asthma; Bronchitis, Chronic; Colitis, Ulcerative; Crohn Disease; Emphysema; Lung Diseases, Obstructive; Nasal Obstruction; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal
Glucocorticoid receptor agonist
Small molecule
Approved
GASTROINTESTINAL; OTHER
INTRAVENOUS; ORAL
Cystic Fibrosis; Laryngopharyngeal Reflux; Neoplasms; Pain; Endometrial Neoplasms; Eosinophilic Esophagitis; Leukemia, Lymphocytic, Chronic, B-Cell; Premature Birth; Pseudomyxoma Peritonei; Rectal Neoplasms; Uterine Cervical Neoplasms; Breast Neoplasms; Diabetes Mellitus, Type 1; Duodenal Ulcer; Esophagitis, Peptic; Gastritis; Gout; Helicobacter Infections; Idiopathic Pulmonary Fibrosis; Lymphoma; Osteoarthritis; Gastroesophageal Reflux; Peptic Ulcer; Stomach Ulcer
Potassium-transporting ATPase inhibitor
Small molecule
Approved
GASTROINTESTINAL; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
INJECTION; INTRAVENOUS
Osteomyelitis; Gram-Negative Bacterial Infections; Pancreatitis; Respiratory Insufficiency; Communicable Diseases; Tuberculosis; Tuberculosis, Pulmonary; Enterobacteriaceae Infections; Neonatal Sepsis; Pneumonia; Pneumonia, Bacterial; Pneumonia, Ventilator-Associated; Pyelonephritis; Sepsis; Shock, Septic; Bacteremia; Bacterial Infections; Infections; Intraabdominal Infections; Meningitis; Meningitis, Bacterial; Urinary Tract Infections
Bacterial penicillin-binding protein inhibitor
Protein
Approved
GASTROINTESTINAL; OTHER
INJECTION
Dyspepsia; Pancreatitis, Chronic; Obesity; Pancreatitis; Schizophrenia; Autistic Disorder
Secretin receptor agonist
Protein
Approved
GASTROINTESTINAL; OTHER
INTRAVENOUS
Autistic Disorder
Secretin receptor agonist
Small molecule
Approved
GASTROINTESTINAL; OTHER
ORAL
Constipation; Irritable Bowel Syndrome
Serotonin 4 (5-HT4) receptor partial agonist
Small molecule
Approved
CANCER; GASTROINTESTINAL; OTHER
INTRAVENOUS; ORAL
Glioblastoma; Heroin Dependence; HIV Infections; Opioid-Related Disorders; Alcoholism; Cocaine-Related Disorders; Gastroparesis; Leukemia, Myeloid, Acute; Marijuana Abuse; Pain; Pruritus; Severe Acute Respiratory Syndrome; Carcinoma, Non-Small-Cell Lung; Depressive Disorder, Major; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Vomiting; Nausea; Neoplasms; Postoperative Nausea and Vomiting
Neurokinin 1 receptor antagonist
Antibody
Approved
GASTROINTESTINAL
INTRAVENOUS
Astrocytoma; Brain Neoplasms; Carcinoma, Adenoid Cystic; Chordoma; Leukemia, Prolymphocytic; Adenocarcinoma; Adenocarcinoma of Lung; Anus Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Verrucous; Cholangiocarcinoma; Complex Regional Pain Syndromes; Endometrial Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Hypopharyngeal Neoplasms; Laryngeal Neoplasms; Liver Neoplasms; Mouth Neoplasms; Multiple Myeloma; Neoplasm Metastasis; Neuralgia; Oropharyngeal Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Skin Neoplasms; Tongue Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Esophageal Neoplasms; Lung Neoplasms; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Head and Neck Neoplasms; Neoplasms
Epidermal growth factor receptor erbB1 inhibitor
Small molecule
Approved
GASTROINTESTINAL; OTHER
ORAL
HIV Infections; Chronic Pain; Constipation; Irritable Bowel Syndrome
Chloride channel protein 2 opener
Small molecule
Approved
GASTROINTESTINAL
ORAL
Clostridium Infections; Diarrhea; Infections
DNA-directed RNA polymerase inhibitor
Protein
Approved
GASTROINTESTINAL
ORAL
Liver Diseases; Thrombocytopenia; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Infections; Virus Diseases
Hepatitis C virus serine protease, NS3/NS4A inhibitor
Small molecule
Approved
GASTROINTESTINAL; OTHER; UROLOGY AND KIDNEY
ORAL
Biliary Tract Neoplasms; Leukemia, Myeloid, Acute; Small Cell Lung Carcinoma; Bile Duct Neoplasms; Carcinoma; Carcinoma, Adenoid Cystic; Carcinoma, Renal Cell; Cholangiocarcinoma; Fallopian Tube Neoplasms; Glioblastoma; Hemangiosarcoma; Liposarcoma; Macular Degeneration; Melanoma; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neoplasms
Discoidin domain-containing receptor 2 inhibitor
Protein
Approved
GASTROINTESTINAL; OTHER
ORAL
Adenoma; Constipation; Irritable Bowel Syndrome
Heat-stable enterotoxin receptor agonist
Small molecule
Approved
GASTROINTESTINAL
ORAL
Breast Neoplasms; Irritable Bowel Syndrome; Acquired Immunodeficiency Syndrome; Diarrhea
Anoctamin-1 blocker
Antibody
Approved
GASTROINTESTINAL
INJECTION
HIV Infections; Inflammatory Bowel Diseases; Melanoma; Celiac Disease; Colitis; Infections; Colitis, Ulcerative; Crohn Disease; Immune System Diseases
Integrin alpha-4/beta-7 inhibitor
Antibody
Approved
GASTROINTESTINAL; OTHER
INJECTION
Desmoplastic Small Round Cell Tumor; Glioma; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Sarcoma, Synovial; Adenocarcinoma; Biliary Tract Neoplasms; Carcinoid Tumor; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Esophageal Neoplasms; Gallbladder Neoplasms; Glioblastoma; Melanoma; Mesothelioma; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Thymoma; Breast Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms
Vascular endothelial growth factor receptor 2 inhibitor
Combination
Approved
GASTROINTESTINAL; OTHER; RHEUMATOLOGY
ORAL
Unknown
Unknown
Combination
Approved
GASTROINTESTINAL
ORAL
Unknown
Unknown
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; GASTROINTESTINAL; OTHER
INJECTION; NASAL; ORAL
Vitamin B 12 Deficiency; Fallopian Tube Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Cutaneous; Meningeal Carcinomatosis; Mycosis Fungoides; Ovarian Neoplasms; Peritoneal Neoplasms; Pulmonary Alveolar Proteinosis; Sezary Syndrome; Arthralgia; Atherosclerosis; Autistic Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Depressive Disorder; Diabetic Neuropathies; Head and Neck Neoplasms; Heart Failure; HIV Infections; Lung Neoplasms; Lymphoma; Lymphoma, T-Cell, Peripheral; Mesothelioma; Myocardial Infarction; Myocardial Ischemia; Nasopharyngeal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Psychotic Disorders; Severe Acute Respiratory Syndrome; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Pregnancy; Psoriasis; Anemia; Anemia, Iron-Deficiency; Diabetes Mellitus, Type 2; Folic Acid Deficiency; Kidney Failure, Chronic; Nasal Obstruction; Osteoporosis; Vitamin B Deficiency
Supplement
Combination
Approved
GASTROINTESTINAL
INTRAVENOUS
Unknown
Unknown
Combination
Approved
GASTROINTESTINAL; OTHER
CAPSULE; DELAYED REL PELLETS; ORAL
Unknown
Unknown