DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 51


Small molecule Approved CANCER; MUSCULOSKELETAL; OTHER; PREGNANCY AND GYNECOLOGY INJECTION; ORAL; TOPICAL; VAGINAL Memory; Reperfusion Injury; Brain Injuries; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Shock; Urinary Bladder, Overactive; Alzheimer Disease; Angina, Unstable; Anorexia Nervosa; Bone Diseases; Bone Diseases, Metabolic; Cardiovascular Diseases; Colonic Neoplasms; Coronary Disease; Cystitis, Interstitial; Diabetes Mellitus; Endometrial Neoplasms; Heart Diseases; Hot Flashes; Hypercholesterolemia; Hypertension; Lupus Erythematosus, Systemic; Memory Disorders; Myocardial Infarction; Myocardial Ischemia; Stroke; Thrombosis; Turner Syndrome; Atrophic Vaginitis; Atrophy; Breast Neoplasms; Dyspareunia; Hypogonadism; Menopause; Osteoporosis; Osteoporosis, Postmenopausal; Primary Ovarian Insufficiency Estrogen receptor agonist

Small molecule

Approved

CANCER; MUSCULOSKELETAL; OTHER; PREGNANCY AND GYNECOLOGY

INJECTION; ORAL; TOPICAL; VAGINAL

Memory; Reperfusion Injury; Brain Injuries; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Shock; Urinary Bladder, Overactive; Alzheimer Disease; Angina, Unstable; Anorexia Nervosa; Bone Diseases; Bone Diseases, Metabolic; Cardiovascular Diseases; Colonic Neoplasms; Coronary Disease; Cystitis, Interstitial; Diabetes Mellitus; Endometrial Neoplasms; Heart Diseases; Hot Flashes; Hypercholesterolemia; Hypertension; Lupus Erythematosus, Systemic; Memory Disorders; Myocardial Infarction; Myocardial Ischemia; Stroke; Thrombosis; Turner Syndrome; Atrophic Vaginitis; Atrophy; Breast Neoplasms; Dyspareunia; Hypogonadism; Menopause; Osteoporosis; Osteoporosis, Postmenopausal; Primary Ovarian Insufficiency

Estrogen receptor agonist


Small molecule Approved CANCER; OTHER INJECTION; ORAL; TOPICAL Hematologic Neoplasms; Arthritis, Rheumatoid; Bronchiolitis Obliterans Syndrome; Crohn Disease; Epidermolysis Bullosa Acquisita; Pancreatic Neoplasms; Scleroderma, Diffuse; Sezary Syndrome; Graft vs Host Disease; Lymphoma; Mycosis Fungoides; Lymphoma, T-Cell; Psoriasis DNA inhibitor


Small molecule Approved CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER BUCCAL; SUBLINGUAL; TRANSDERMAL Burns; Opioid-Related Disorders; Respiratory Distress Syndrome; Brain Injuries; Breast Neoplasms; Delirium; Fractures, Bone; Hypospadias; Hypotension; Irritable Bowel Syndrome; Pregnancy; Pulpitis; Scoliosis; Subarachnoid Hemorrhage; Abscess; Adenoma; Aortic Coarctation; Diabetic Neuropathies; Liver Diseases; Low Back Pain; Lung Diseases; Migraine Disorders; Neoplasm Metastasis; Obesity; Obesity, Morbid; Osteoarthritis; Pancreatic Neoplasms; Renal Insufficiency, Chronic; Respiratory Insufficiency; Severe Acute Respiratory Syndrome; Sleep Apnea, Obstructive; Stomach Neoplasms; Acute Pain; Cancer Pain; Chronic Pain; Neoplasms; Pain Mu opioid receptor agonist

Small molecule

Approved

CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

BUCCAL; SUBLINGUAL; TRANSDERMAL

Burns; Opioid-Related Disorders; Respiratory Distress Syndrome; Brain Injuries; Breast Neoplasms; Delirium; Fractures, Bone; Hypospadias; Hypotension; Irritable Bowel Syndrome; Pregnancy; Pulpitis; Scoliosis; Subarachnoid Hemorrhage; Abscess; Adenoma; Aortic Coarctation; Diabetic Neuropathies; Liver Diseases; Low Back Pain; Lung Diseases; Migraine Disorders; Neoplasm Metastasis; Obesity; Obesity, Morbid; Osteoarthritis; Pancreatic Neoplasms; Renal Insufficiency, Chronic; Respiratory Insufficiency; Severe Acute Respiratory Syndrome; Sleep Apnea, Obstructive; Stomach Neoplasms; Acute Pain; Cancer Pain; Chronic Pain; Neoplasms; Pain

Mu opioid receptor agonist


Protein Approved CANCER; HEMATOLOGY; OTHER UNKNOWN Alzheimer Disease; beta-Thalassemia; Blast Crisis; Carcinoma, Endometrioid; Chordoma; Coronary Disease; Cystadenoma, Serous; Enterocolitis, Necrotizing; Ganglioneuroblastoma; Glioma; Granulomatous Disease, Chronic; Hemangiosarcoma; Immunologic Deficiency Syndromes; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Lymphoma, B-Cell, Marginal Zone; Menopause; Multiple Sclerosis; Muscular Diseases; Myasthenia Gravis; Neoplasm Metastasis; Neurilemmoma; Peripheral Arterial Disease; Peripheral Vascular Diseases; Primary Myelofibrosis; Sarcoma, Synovial; Severe Combined Immunodeficiency; Stiff-Person Syndrome; Vasculitis; Waldenstrom Macroglobulinemia; Amyotrophic Lateral Sclerosis; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Biliary Atresia; Breast Neoplasms, Male; Carcinoid Tumor; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cardiomyopathy, Dilated; Cerebral Palsy; Colorectal Neoplasms; Crohn Disease; Diabetes Mellitus, Type 1; Endometriosis; Epidermolysis Bullosa Dystrophica; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fanconi Anemia; Gallbladder Neoplasms; Glioblastoma; Gliosarcoma; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; HIV Infections; Infertility; Inflammatory Breast Neoplasms; Ischemic Stroke; Leukemia, Mast-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Liver Neoplasms; Lupus Erythematosus, Systemic; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Lymphopenia; Myelodysplastic-Myeloproliferative Diseases; Nasopharyngeal Carcinoma; Neuromyelitis Optica; Osteosarcoma; Pancreatic Neoplasms; Parkinson Disease; Pemphigus; Peritoneal Neoplasms; Prostatic Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Stroke; Urethral Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Adrenal Cortex Neoplasms; Amyloidosis, Familial; Anemia; Anemia, Aplastic; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Chagas Cardiomyopathy; Endometrial Neoplasms; Ependymoma; Fever; Graft vs Host Disease; Head and Neck Neoplasms; Hepatitis, Alcoholic; Hodgkin Disease; Hot Flashes; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Diseases; Liver Failure; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mediastinal Neoplasms; Medulloblastoma; Melanoma; Multiple Myeloma; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Myeloproliferative Disorders; Myocardial Infarction; Neoplasms, Germ Cell and Embryonal; Neoplasms, Plasma Cell; Neuroblastoma; Neuroectodermal Tumors, Primitive; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Ovarian Insufficiency; Prostatic Neoplasms, Castration-Resistant; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Scleroderma, Systemic; ST Elevation Myocardial Infarction; Testicular Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Hematopoietic Stem Cell Transplantation; Infections; Neoplasms; Neutropenia Granulocyte colony stimulating factor receptor agonist

Protein

Approved

CANCER; HEMATOLOGY; OTHER

UNKNOWN

Alzheimer Disease; beta-Thalassemia; Blast Crisis; Carcinoma, Endometrioid; Chordoma; Coronary Disease; Cystadenoma, Serous; Enterocolitis, Necrotizing; Ganglioneuroblastoma; Glioma; Granulomatous Disease, Chronic; Hemangiosarcoma; Immunologic Deficiency Syndromes; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Lymphoma, B-Cell, Marginal Zone; Menopause; Multiple Sclerosis; Muscular Diseases; Myasthenia Gravis; Neoplasm Metastasis; Neurilemmoma; Peripheral Arterial Disease; Peripheral Vascular Diseases; Primary Myelofibrosis; Sarcoma, Synovial; Severe Combined Immunodeficiency; Stiff-Person Syndrome; Vasculitis; Waldenstrom Macroglobulinemia; Amyotrophic Lateral Sclerosis; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Biliary Atresia; Breast Neoplasms, Male; Carcinoid Tumor; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cardiomyopathy, Dilated; Cerebral Palsy; Colorectal Neoplasms; Crohn Disease; Diabetes Mellitus, Type 1; Endometriosis; Epidermolysis Bullosa Dystrophica; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fanconi Anemia; Gallbladder Neoplasms; Glioblastoma; Gliosarcoma; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; HIV Infections; Infertility; Inflammatory Breast Neoplasms; Ischemic Stroke; Leukemia, Mast-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Liver Neoplasms; Lupus Erythematosus, Systemic; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Lymphopenia; Myelodysplastic-Myeloproliferative Diseases; Nasopharyngeal Carcinoma; Neuromyelitis Optica; Osteosarcoma; Pancreatic Neoplasms; Parkinson Disease; Pemphigus; Peritoneal Neoplasms; Prostatic Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Stroke; Urethral Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Adrenal Cortex Neoplasms; Amyloidosis, Familial; Anemia; Anemia, Aplastic; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Chagas Cardiomyopathy; Endometrial Neoplasms; Ependymoma; Fever; Graft vs Host Disease; Head and Neck Neoplasms; Hepatitis, Alcoholic; Hodgkin Disease; Hot Flashes; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Diseases; Liver Failure; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mediastinal Neoplasms; Medulloblastoma; Melanoma; Multiple Myeloma; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Myeloproliferative Disorders; Myocardial Infarction; Neoplasms, Germ Cell and Embryonal; Neoplasms, Plasma Cell; Neuroblastoma; Neuroectodermal Tumors, Primitive; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Ovarian Insufficiency; Prostatic Neoplasms, Castration-Resistant; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Scleroderma, Systemic; ST Elevation Myocardial Infarction; Testicular Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Hematopoietic Stem Cell Transplantation; Infections; Neoplasms; Neutropenia

Granulocyte colony stimulating factor receptor agonist


Small molecule Approved CANCER; OTHER; RESPIRATORY INJECTION; IV (INFUSION) Anus Neoplasms; Brain Neoplasms; Carcinoid Tumor; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Renal Cell; Carcinoma, Small Cell; Carcinoma, Verrucous; Coronary Restenosis; Glioblastoma; Gliosarcoma; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Liver Neoplasms; Mesothelioma; Neoplasms, Cystic, Mucinous, and Serous; Rectal Neoplasms; Thyroid Carcinoma, Anaplastic; Vaginal Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Adrenal Cortex Neoplasms; Arthritis, Rheumatoid; Bone Neoplasms; Breast Carcinoma In Situ; Carcinoma, Ductal; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Constriction, Pathologic; Cystadenoma, Serous; Digestive System Diseases; Gallbladder Neoplasms; Gastrointestinal Stromal Tumors; Glioma; Hemangiosarcoma; Hereditary Breast and Ovarian Cancer Syndrome; Hypopharyngeal Neoplasms; Keratosis, Actinic; Kidney Neoplasms; Leukemia; Lymphoma; Mouth Neoplasms; Multiple Myeloma; Neoplasms, Complex and Mixed; Neoplasms, Germ Cell and Embryonal; Oropharyngeal Neoplasms; Penile Neoplasms; Peripheral Vascular Diseases; Prostatic Hyperplasia; Prostatic Neoplasms; Psoriasis; Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Thymoma; Uterine Cervical Dysplasia; Uveal Melanoma; Vulvar Neoplasms; Adenocarcinoma; Adenocarcinoma of Lung; Anemia; Biliary Tract Neoplasms; Breast Neoplasms, Male; Carcinoma, Large Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Gestational Trophoblastic Disease; Head and Neck Neoplasms; HIV Infections; Hypersensitivity; Inflammatory Breast Neoplasms; Ischemia; Lung Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Pain; Paraganglioma; Peripheral Arterial Disease; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Retroviridae Infections; Sarcoma; Sex Cord-Gonadal Stromal Tumors; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Sarcoma, Kaposi Tubulin inhibitor

Small molecule

Approved

CANCER; OTHER; RESPIRATORY

INJECTION; IV (INFUSION)

Anus Neoplasms; Brain Neoplasms; Carcinoid Tumor; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Renal Cell; Carcinoma, Small Cell; Carcinoma, Verrucous; Coronary Restenosis; Glioblastoma; Gliosarcoma; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Liver Neoplasms; Mesothelioma; Neoplasms, Cystic, Mucinous, and Serous; Rectal Neoplasms; Thyroid Carcinoma, Anaplastic; Vaginal Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Adrenal Cortex Neoplasms; Arthritis, Rheumatoid; Bone Neoplasms; Breast Carcinoma In Situ; Carcinoma, Ductal; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Constriction, Pathologic; Cystadenoma, Serous; Digestive System Diseases; Gallbladder Neoplasms; Gastrointestinal Stromal Tumors; Glioma; Hemangiosarcoma; Hereditary Breast and Ovarian Cancer Syndrome; Hypopharyngeal Neoplasms; Keratosis, Actinic; Kidney Neoplasms; Leukemia; Lymphoma; Mouth Neoplasms; Multiple Myeloma; Neoplasms, Complex and Mixed; Neoplasms, Germ Cell and Embryonal; Oropharyngeal Neoplasms; Penile Neoplasms; Peripheral Vascular Diseases; Prostatic Hyperplasia; Prostatic Neoplasms; Psoriasis; Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Thymoma; Uterine Cervical Dysplasia; Uveal Melanoma; Vulvar Neoplasms; Adenocarcinoma; Adenocarcinoma of Lung; Anemia; Biliary Tract Neoplasms; Breast Neoplasms, Male; Carcinoma, Large Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Gestational Trophoblastic Disease; Head and Neck Neoplasms; HIV Infections; Hypersensitivity; Inflammatory Breast Neoplasms; Ischemia; Lung Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Pain; Paraganglioma; Peripheral Arterial Disease; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Retroviridae Infections; Sarcoma; Sex Cord-Gonadal Stromal Tumors; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Sarcoma, Kaposi

Tubulin inhibitor


Protein Approved CANCER UNKNOWN Abortion, Habitual; Acquired Immunodeficiency Syndrome; Adenocarcinoma of Lung; Alopecia Areata; Anemia, Hemolytic, Autoimmune; Blast Crisis; Brain Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Cryoglobulinemia; Cytomegalovirus Infections; Encephalitis; Glioblastoma; Glioma; Gliosarcoma; Hematologic Neoplasms; Leukemia, Biphenotypic, Acute; Lymphoma, T-Cell, Cutaneous; Macrophage Activation Syndrome; Mesothelioma; Mycosis Fungoides; Myelodysplastic-Myeloproliferative Diseases; Myocardial Ischemia; Neoplasm Metastasis; Pancreatic Neoplasms; Papillomavirus Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Sarcoma, Synovial; Sezary Syndrome; Squamous Intraepithelial Lesions; Thyroid Neoplasms; Uterine Cervical Neoplasms; Wiskott-Aldrich Syndrome; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Behcet Syndrome; Breast Neoplasms, Male; Bronchiolitis Obliterans Syndrome; Carcinoma; Central Nervous System Neoplasms; Conjunctivitis, Allergic; Crohn Disease; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Graft vs Host Disease; Hodgkin Disease; Inflammatory Breast Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myeloproliferative Disorders; Myositis; Nephrotic Syndrome; Ovarian Neoplasms; Peritoneal Neoplasms; Polychondritis, Relapsing; Polymyalgia Rheumatica; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Uveal Melanoma; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Renal Cell; Dermatomyositis; Head and Neck Neoplasms; HIV Infections; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Lupus Erythematosus, Systemic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Neuroblastoma; Severe Acute Respiratory Syndrome; Skin Neoplasms; Melanoma; Neoplasms Interleukin-2 receptor agonist

Protein

Approved

CANCER

UNKNOWN

Abortion, Habitual; Acquired Immunodeficiency Syndrome; Adenocarcinoma of Lung; Alopecia Areata; Anemia, Hemolytic, Autoimmune; Blast Crisis; Brain Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Cryoglobulinemia; Cytomegalovirus Infections; Encephalitis; Glioblastoma; Glioma; Gliosarcoma; Hematologic Neoplasms; Leukemia, Biphenotypic, Acute; Lymphoma, T-Cell, Cutaneous; Macrophage Activation Syndrome; Mesothelioma; Mycosis Fungoides; Myelodysplastic-Myeloproliferative Diseases; Myocardial Ischemia; Neoplasm Metastasis; Pancreatic Neoplasms; Papillomavirus Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Sarcoma, Synovial; Sezary Syndrome; Squamous Intraepithelial Lesions; Thyroid Neoplasms; Uterine Cervical Neoplasms; Wiskott-Aldrich Syndrome; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Behcet Syndrome; Breast Neoplasms, Male; Bronchiolitis Obliterans Syndrome; Carcinoma; Central Nervous System Neoplasms; Conjunctivitis, Allergic; Crohn Disease; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Graft vs Host Disease; Hodgkin Disease; Inflammatory Breast Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myeloproliferative Disorders; Myositis; Nephrotic Syndrome; Ovarian Neoplasms; Peritoneal Neoplasms; Polychondritis, Relapsing; Polymyalgia Rheumatica; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Uveal Melanoma; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Renal Cell; Dermatomyositis; Head and Neck Neoplasms; HIV Infections; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Lupus Erythematosus, Systemic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Neuroblastoma; Severe Acute Respiratory Syndrome; Skin Neoplasms; Melanoma; Neoplasms

Interleukin-2 receptor agonist


Small molecule Approved CANCER SUBCUTANEOUS; TRANSDERMAL Gastroparesis; Glioma; Leukemia, Mast-Cell; Lymphoma; Pruritus; Carcinoma, Hepatocellular; Pain; Uterine Cervical Neoplasms; Nausea; Neoplasms; Postoperative Nausea and Vomiting; Vomiting Serotonin 3a (5-HT3a) receptor antagonist


Small molecule Approved CANCER; OTHER ORAL Aging; Breast Diseases; Endometrial Neoplasms; Hypertension; Kallmann Syndrome; Anovulation; Breast Neoplasms, Male; Carcinoma; Endometriosis; Fibrous Dysplasia, Polyostotic; Hypertension, Pulmonary; Hypogonadism; Hypopituitarism; Metabolic Syndrome; Puberty, Precocious; Triple Negative Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; Gynecomastia; Klinefelter Syndrome; Ovarian Neoplasms; Breast Neoplasms; Neoplasms Cytochrome P450 19A1 inhibitor

Small molecule

Approved

CANCER; OTHER

ORAL

Aging; Breast Diseases; Endometrial Neoplasms; Hypertension; Kallmann Syndrome; Anovulation; Breast Neoplasms, Male; Carcinoma; Endometriosis; Fibrous Dysplasia, Polyostotic; Hypertension, Pulmonary; Hypogonadism; Hypopituitarism; Metabolic Syndrome; Puberty, Precocious; Triple Negative Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; Gynecomastia; Klinefelter Syndrome; Ovarian Neoplasms; Breast Neoplasms; Neoplasms

Cytochrome P450 19A1 inhibitor


Unknown Approved CANCER ORAL Unknown Unknown


Small molecule Approved CANCER; OTHER; PREGNANCY AND GYNECOLOGY INJECTION; INTRAVENOUS Breast Neoplasms, Male; Carcinoma, Endometrioid; Carcinoma, Renal Cell; Colonic Neoplasms; Cystadenoma, Serous; Digestive System Diseases; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Nausea; Neoplasms, Plasma Cell; Sarcoma, Synovial; Vaginal Neoplasms; Vulvar Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hereditary Breast and Ovarian Cancer Syndrome; Leiomyosarcoma; Leukemia; Liver Neoplasms; Mediastinal Neoplasms; Melanoma; Osteosarcoma; Pancreatic Neoplasms; Penile Neoplasms; Retroviridae Infections; Salivary Gland Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Testicular Neoplasms; Thyroid Carcinoma, Anaplastic; Tonsillar Neoplasms; Triple Negative Breast Neoplasms; Urethral Neoplasms; Uterine Neoplasms; Adenocarcinoma of Lung; Anorexia; Cachexia; Carcinoma; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fatigue; Genital Neoplasms, Male; Hypersensitivity; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Mouth Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neutropenia; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paranasal Sinus Neoplasms; Peritoneal Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Neoplasms; Prostatic Neoplasms; Stomach Neoplasms Tubulin inhibitor

Small molecule

Approved

CANCER; OTHER; PREGNANCY AND GYNECOLOGY

INJECTION; INTRAVENOUS

Breast Neoplasms, Male; Carcinoma, Endometrioid; Carcinoma, Renal Cell; Colonic Neoplasms; Cystadenoma, Serous; Digestive System Diseases; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Nausea; Neoplasms, Plasma Cell; Sarcoma, Synovial; Vaginal Neoplasms; Vulvar Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hereditary Breast and Ovarian Cancer Syndrome; Leiomyosarcoma; Leukemia; Liver Neoplasms; Mediastinal Neoplasms; Melanoma; Osteosarcoma; Pancreatic Neoplasms; Penile Neoplasms; Retroviridae Infections; Salivary Gland Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Testicular Neoplasms; Thyroid Carcinoma, Anaplastic; Tonsillar Neoplasms; Triple Negative Breast Neoplasms; Urethral Neoplasms; Uterine Neoplasms; Adenocarcinoma of Lung; Anorexia; Cachexia; Carcinoma; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fatigue; Genital Neoplasms, Male; Hypersensitivity; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Mouth Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neutropenia; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paranasal Sinus Neoplasms; Peritoneal Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Neoplasms; Prostatic Neoplasms; Stomach Neoplasms

Tubulin inhibitor


Small molecule Approved CANCER; OTHER ORAL Carcinoma, Merkel Cell; Central Nervous System Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Urinary Bladder Neoplasms; Anus Neoplasms; Bile Duct Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Lung Neoplasms; Mesothelioma; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paraganglioma; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pseudomyxoma Peritonei; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thyroid Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Brain Diseases; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Esophageal Neoplasms; Gallbladder Neoplasms; Hand-Foot Syndrome; Liver Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Neoplasms; Stomach Neoplasms DNA inhibitor

Small molecule

Approved

CANCER; OTHER

ORAL

Carcinoma, Merkel Cell; Central Nervous System Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Urinary Bladder Neoplasms; Anus Neoplasms; Bile Duct Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Lung Neoplasms; Mesothelioma; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paraganglioma; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pseudomyxoma Peritonei; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thyroid Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Brain Diseases; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Esophageal Neoplasms; Gallbladder Neoplasms; Hand-Foot Syndrome; Liver Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Neoplasms; Stomach Neoplasms

DNA inhibitor


Small molecule Approved CANCER; OTHER INTRAVENOUS; ORAL Cytomegalovirus Infections; Desmoplastic Small Round Cell Tumor; Ependymoma; Fallopian Tube Neoplasms; Meningitis, Aseptic; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Wilms Tumor; Biliary Tract Neoplasms; Brain Diseases; Brain Stem Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hereditary Breast and Ovarian Cancer Syndrome; Leiomyosarcoma; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Myelodysplastic Syndromes; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Neurofibromatosis 1; Ovarian Neoplasms; Pancreatic Neoplasms; Pheochromocytoma; Pinealoma; Pituitary Neoplasms; Rectal Neoplasms; Retinoblastoma; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Spinal Cord Neoplasms; Uveal Melanoma; Astrocytoma; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Choroid Plexus Neoplasms; Diffuse Intrinsic Pontine Glioma; Ganglioneuroblastoma; Gliosarcoma; Melanoma; Neoplasm Metastasis; Neuroblastoma; Oligodendroglioma; Optic Nerve Glioma; Paraganglioma; Sarcoma, Ewing; Glioblastoma; Glioma; Neoplasms DNA inhibitor

Small molecule

Approved

CANCER; OTHER

INTRAVENOUS; ORAL

Cytomegalovirus Infections; Desmoplastic Small Round Cell Tumor; Ependymoma; Fallopian Tube Neoplasms; Meningitis, Aseptic; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Wilms Tumor; Biliary Tract Neoplasms; Brain Diseases; Brain Stem Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hereditary Breast and Ovarian Cancer Syndrome; Leiomyosarcoma; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Myelodysplastic Syndromes; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Neurofibromatosis 1; Ovarian Neoplasms; Pancreatic Neoplasms; Pheochromocytoma; Pinealoma; Pituitary Neoplasms; Rectal Neoplasms; Retinoblastoma; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Spinal Cord Neoplasms; Uveal Melanoma; Astrocytoma; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Choroid Plexus Neoplasms; Diffuse Intrinsic Pontine Glioma; Ganglioneuroblastoma; Gliosarcoma; Melanoma; Neoplasm Metastasis; Neuroblastoma; Oligodendroglioma; Optic Nerve Glioma; Paraganglioma; Sarcoma, Ewing; Glioblastoma; Glioma; Neoplasms

DNA inhibitor


Antibody Approved CANCER INJECTION; SINGLE-DOSE Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelomonocytic, Juvenile; Leukemia, Promyelocytic, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia; Myelodysplastic Syndromes; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neoplasms DNA disrupting agent


Antibody Approved CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER INJECTION; INTRAVENOUS Anemia; Arthritis, Rheumatoid; Epidermolysis Bullosa; Fallopian Tube Neoplasms; Fanconi Anemia; Kidney Diseases; Leukemia, Prolymphocytic, T-Cell; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms, Neuroepithelial; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Renal Insufficiency; Vasculitis; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; beta-Thalassemia; Crohn Disease; Diabetes Mellitus, Type 1; Graft vs Host Disease; Granulomatous Disease, Chronic; Hematologic Neoplasms; Hemoglobinopathies; Histiocytosis; Hodgkin Disease; Immune System Diseases; Kidney Failure, Chronic; Kidney Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphoid; Leukemia, Prolymphocytic; Liver Diseases; Lymphoma, Large B-Cell, Diffuse; Mycosis Fungoides; Myeloproliferative Disorders; Myositis, Inclusion Body; Neoplasms; Osteopetrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Severe Combined Immunodeficiency; Sezary Syndrome; Thalassemia; Waldenstrom Macroglobulinemia; Anemia, Sickle Cell; Granuloma, Lethal Midline; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, T-Cell, Peripheral; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Sclerosis CAMPATH-1 antigen inhibitor

Antibody

Approved

CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

INJECTION; INTRAVENOUS

Anemia; Arthritis, Rheumatoid; Epidermolysis Bullosa; Fallopian Tube Neoplasms; Fanconi Anemia; Kidney Diseases; Leukemia, Prolymphocytic, T-Cell; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms, Neuroepithelial; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Renal Insufficiency; Vasculitis; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; beta-Thalassemia; Crohn Disease; Diabetes Mellitus, Type 1; Graft vs Host Disease; Granulomatous Disease, Chronic; Hematologic Neoplasms; Hemoglobinopathies; Histiocytosis; Hodgkin Disease; Immune System Diseases; Kidney Failure, Chronic; Kidney Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphoid; Leukemia, Prolymphocytic; Liver Diseases; Lymphoma, Large B-Cell, Diffuse; Mycosis Fungoides; Myeloproliferative Disorders; Myositis, Inclusion Body; Neoplasms; Osteopetrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Severe Combined Immunodeficiency; Sezary Syndrome; Thalassemia; Waldenstrom Macroglobulinemia; Anemia, Sickle Cell; Granuloma, Lethal Midline; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, T-Cell, Peripheral; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Sclerosis

CAMPATH-1 antigen inhibitor


Small molecule Approved CANCER; DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER INJECTION; INTRAVENOUS; IV (INFUSION) Adenocarcinoma; Anemia, Sickle Cell; Chondrosarcoma; Menopause; Neuroblastoma; beta-Thalassemia; Bone Resorption; Carcinoma, Intraductal, Noninfiltrating; Complex Regional Pain Syndromes; Kidney Neoplasms; Leiomyosarcoma; Low Back Pain; Macular Degeneration; Mesothelioma; Nasopharyngeal Neoplasms; Osteosarcoma; Pancreatic Neoplasms; Primary Myelofibrosis; Progeria; Urogenital Neoplasms; Uterine Cervical Neoplasms; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Bone Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Giant Cell Tumors; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms, Plasma Cell; Osteoarthritis, Hip; Osteogenesis Imperfecta; Osteonecrosis; Pain; Plasmacytoma; Sarcoma; Sarcoma, Ewing; Spinal Cord Injuries; Bone Diseases; Fractures, Bone; Hypercalcemia; Multiple Myeloma; Neoplasm Metastasis; Osteitis Deformans; Osteoporosis; Osteoporosis, Postmenopausal; Prostatic Neoplasms Farnesyl diphosphate synthase inhibitor

Small molecule

Approved

CANCER; DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER

INJECTION; INTRAVENOUS; IV (INFUSION)

Adenocarcinoma; Anemia, Sickle Cell; Chondrosarcoma; Menopause; Neuroblastoma; beta-Thalassemia; Bone Resorption; Carcinoma, Intraductal, Noninfiltrating; Complex Regional Pain Syndromes; Kidney Neoplasms; Leiomyosarcoma; Low Back Pain; Macular Degeneration; Mesothelioma; Nasopharyngeal Neoplasms; Osteosarcoma; Pancreatic Neoplasms; Primary Myelofibrosis; Progeria; Urogenital Neoplasms; Uterine Cervical Neoplasms; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Bone Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Giant Cell Tumors; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms, Plasma Cell; Osteoarthritis, Hip; Osteogenesis Imperfecta; Osteonecrosis; Pain; Plasmacytoma; Sarcoma; Sarcoma, Ewing; Spinal Cord Injuries; Bone Diseases; Fractures, Bone; Hypercalcemia; Multiple Myeloma; Neoplasm Metastasis; Osteitis Deformans; Osteoporosis; Osteoporosis, Postmenopausal; Prostatic Neoplasms

Farnesyl diphosphate synthase inhibitor


Enzyme Approved CANCER INTRAVENOUS Burkitt Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Lysis Syndrome; Gout; Hyperuricemia; Leukemia; Lymphoma Uric acid oxidative enzyme


Protein Approved CANCER UNKNOWN Brain Neoplasms; Coronary Disease; Glioma; Lymphoma, Follicular; Lymphoma, T-Cell, Cutaneous; Neuroblastoma; Osteosarcoma; Adenocarcinoma of Lung; Anemia, Aplastic; Breast Neoplasms, Male; Carcinoid Tumor; Carcinoma, Islet Cell; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Medulloblastoma; Melanoma; Myelodysplastic Syndromes; Nasopharyngeal Carcinoma; Neoplasms, Plasma Cell; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Rectal Neoplasms; Retinoblastoma; Small Cell Lung Carcinoma; Stomach Neoplasms; Testicular Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Adrenal Cortex Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Esophageal Neoplasms; Hodgkin Disease; Lung Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Triple Negative Breast Neoplasms; Uterine Neoplasms; Infections; Neoplasms; Neutropenia Granulocyte colony stimulating factor receptor agonist

Protein

Approved

CANCER

UNKNOWN

Brain Neoplasms; Coronary Disease; Glioma; Lymphoma, Follicular; Lymphoma, T-Cell, Cutaneous; Neuroblastoma; Osteosarcoma; Adenocarcinoma of Lung; Anemia, Aplastic; Breast Neoplasms, Male; Carcinoid Tumor; Carcinoma, Islet Cell; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Medulloblastoma; Melanoma; Myelodysplastic Syndromes; Nasopharyngeal Carcinoma; Neoplasms, Plasma Cell; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Rectal Neoplasms; Retinoblastoma; Small Cell Lung Carcinoma; Stomach Neoplasms; Testicular Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Adrenal Cortex Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Esophageal Neoplasms; Hodgkin Disease; Lung Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Triple Negative Breast Neoplasms; Uterine Neoplasms; Infections; Neoplasms; Neutropenia

Granulocyte colony stimulating factor receptor agonist


Antibody Approved CANCER INJECTION Lymphoma; Lymphoma, Follicular; Lymphoma, Non-Hodgkin Unknown


Small molecule Approved CANCER; OTHER INJECTION; INTRAVENOUS Digestive System Diseases; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Diseases; Lymphoma, T-Cell, Cutaneous; Melanoma; Myelodysplastic Syndromes; Neuroblastoma; Triple Negative Breast Neoplasms; Anus Neoplasms; Bile Duct Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Digestive System Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Klatskin Tumor; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Mesothelioma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroendocrine Tumors; Ovarian Neoplasms; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Esophageal Neoplasms; Gallbladder Neoplasms; Granuloma, Lethal Midline; Hepatoblastoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasm Metastasis; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Neoplasms DNA inhibitor

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS

Digestive System Diseases; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Diseases; Lymphoma, T-Cell, Cutaneous; Melanoma; Myelodysplastic Syndromes; Neuroblastoma; Triple Negative Breast Neoplasms; Anus Neoplasms; Bile Duct Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Digestive System Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Klatskin Tumor; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Mesothelioma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroendocrine Tumors; Ovarian Neoplasms; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Esophageal Neoplasms; Gallbladder Neoplasms; Granuloma, Lethal Midline; Hepatoblastoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasm Metastasis; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Neoplasms

DNA inhibitor


Small molecule Approved CANCER INTRAMUSCULAR Carcinoma, Ductal; Carcinoma, Squamous Cell; Colorectal Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Lymphoma; Lymphoma, Non-Hodgkin; Mesothelioma; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Fibrous Dysplasia, Polyostotic; Genital Neoplasms, Female; Hypertension, Pulmonary; Lung Neoplasms; Lupus Erythematosus, Systemic; Ovarian Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Puberty, Precocious; Sarcoma, Endometrial Stromal; Carcinoma, Lobular; Neoplasm Metastasis; Breast Neoplasms; Neoplasms Estrogen receptor alpha antagonist

Small molecule

Approved

CANCER

INTRAMUSCULAR

Carcinoma, Ductal; Carcinoma, Squamous Cell; Colorectal Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Lymphoma; Lymphoma, Non-Hodgkin; Mesothelioma; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Fibrous Dysplasia, Polyostotic; Genital Neoplasms, Female; Hypertension, Pulmonary; Lung Neoplasms; Lupus Erythematosus, Systemic; Ovarian Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Puberty, Precocious; Sarcoma, Endometrial Stromal; Carcinoma, Lobular; Neoplasm Metastasis; Breast Neoplasms; Neoplasms

Estrogen receptor alpha antagonist


Small molecule Approved CANCER; GASTROINTESTINAL; OTHER INTRAVENOUS; ORAL Glioblastoma; Heroin Dependence; HIV Infections; Opioid-Related Disorders; Alcoholism; Cocaine-Related Disorders; Gastroparesis; Leukemia, Myeloid, Acute; Marijuana Abuse; Pain; Pruritus; Severe Acute Respiratory Syndrome; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Depressive Disorder, Major; Dysmenorrhea; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Nausea; Neoplasms; Postoperative Nausea and Vomiting; Vomiting Neurokinin 1 receptor antagonist

Small molecule

Approved

CANCER; GASTROINTESTINAL; OTHER

INTRAVENOUS; ORAL

Glioblastoma; Heroin Dependence; HIV Infections; Opioid-Related Disorders; Alcoholism; Cocaine-Related Disorders; Gastroparesis; Leukemia, Myeloid, Acute; Marijuana Abuse; Pain; Pruritus; Severe Acute Respiratory Syndrome; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Depressive Disorder, Major; Dysmenorrhea; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Nausea; Neoplasms; Postoperative Nausea and Vomiting; Vomiting

Neurokinin 1 receptor antagonist


Protein Approved CANCER INTRAMUSCULAR Prostatic Neoplasms, Castration-Resistant; Neoplasms Gonadotropin-releasing hormone receptor antagonist


Small molecule Approved CANCER INJECTION; INTRAVENOUS; SUBCUTANEOUS; UNKNOWN Anemia, Refractory, with Excess of Blasts; Astrocytoma; Burkitt Lymphoma; Carcinoma, Medullary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Immunoblastic Lymphadenopathy; Leukemia, Lymphoid; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Muscular Dystrophies; Mycosis Fungoides; Myeloproliferative Disorders; Neuroblastoma; Oligodendroglioma; Peritoneal Neoplasms; Sezary Syndrome; Smoldering Multiple Myeloma; Uremia; Adenocarcinoma, Follicular; Adenocarcinoma of Lung; Anemia, Hemolytic, Autoimmune; Autoimmune Diseases of the Nervous System; Breast Neoplasms; Bronchiolitis Obliterans; Bronchiolitis Obliterans Syndrome; Carcinoma, Adenoid Cystic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Castleman Disease; Central Nervous System Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Glioblastoma; Gliosarcoma; Graft vs Host Disease; Head and Neck Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Immune System Diseases; Kidney Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Lung Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Lymphoproliferative Disorders; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neoplasms, Plasma Cell; Neuromyelitis Optica; Ovarian Neoplasms; Pancreatic Neoplasms; Paraganglioma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Red-Cell Aplasia, Pure; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uveal Melanoma; Amyloidosis; Amyloidosis, Familial; Cholangiocarcinoma; Immunoglobulin Light-chain Amyloidosis; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Multiple Myeloma; Plasmacytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Renal Insufficiency, Chronic; Sarcoma, Myeloid; Waldenstrom Macroglobulinemia; Neoplasms 26S proteasome inhibitor

Small molecule

Approved

CANCER

INJECTION; INTRAVENOUS; SUBCUTANEOUS; UNKNOWN

Anemia, Refractory, with Excess of Blasts; Astrocytoma; Burkitt Lymphoma; Carcinoma, Medullary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Immunoblastic Lymphadenopathy; Leukemia, Lymphoid; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Muscular Dystrophies; Mycosis Fungoides; Myeloproliferative Disorders; Neuroblastoma; Oligodendroglioma; Peritoneal Neoplasms; Sezary Syndrome; Smoldering Multiple Myeloma; Uremia; Adenocarcinoma, Follicular; Adenocarcinoma of Lung; Anemia, Hemolytic, Autoimmune; Autoimmune Diseases of the Nervous System; Breast Neoplasms; Bronchiolitis Obliterans; Bronchiolitis Obliterans Syndrome; Carcinoma, Adenoid Cystic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Castleman Disease; Central Nervous System Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Glioblastoma; Gliosarcoma; Graft vs Host Disease; Head and Neck Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Immune System Diseases; Kidney Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Lung Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Lymphoproliferative Disorders; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neoplasms, Plasma Cell; Neuromyelitis Optica; Ovarian Neoplasms; Pancreatic Neoplasms; Paraganglioma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Red-Cell Aplasia, Pure; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uveal Melanoma; Amyloidosis; Amyloidosis, Familial; Cholangiocarcinoma; Immunoglobulin Light-chain Amyloidosis; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Multiple Myeloma; Plasmacytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Renal Insufficiency, Chronic; Sarcoma, Myeloid; Waldenstrom Macroglobulinemia; Neoplasms

26S proteasome inhibitor


Small molecule Approved CANCER ORAL Carcinoma; Carcinoma, Renal Cell; Nasopharyngeal Carcinoma; Pancreatic Neoplasms; Prostatic Neoplasms; Bile Duct Neoplasms; Breast Neoplasms, Male; Central Nervous System Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Glioblastoma; Gliosarcoma; Kidney Neoplasms; Leukemia, Myeloid, Acute; Liver Neoplasms; Mesothelioma; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Salivary Gland Neoplasms; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Urethral Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Lung Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms Epidermal growth factor receptor erbB1 inhibitor

Small molecule

Approved

CANCER

ORAL

Carcinoma; Carcinoma, Renal Cell; Nasopharyngeal Carcinoma; Pancreatic Neoplasms; Prostatic Neoplasms; Bile Duct Neoplasms; Breast Neoplasms, Male; Central Nervous System Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Glioblastoma; Gliosarcoma; Kidney Neoplasms; Leukemia, Myeloid, Acute; Liver Neoplasms; Mesothelioma; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Salivary Gland Neoplasms; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Urethral Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Lung Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms

Epidermal growth factor receptor erbB1 inhibitor


Small molecule Approved CANCER; OTHER INJECTION; INTRAVENOUS; IV (INFUSION) Chordoma; Endometrial Neoplasms; Glioma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Primary Myelofibrosis; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Uveal Melanoma; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Meningeal Carcinomatosis; Mesothelioma, Malignant; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms Dihydrofolate reductase inhibitor

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS; IV (INFUSION)

Chordoma; Endometrial Neoplasms; Glioma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Primary Myelofibrosis; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Uveal Melanoma; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Meningeal Carcinomatosis; Mesothelioma, Malignant; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms

Dihydrofolate reductase inhibitor

Small molecule

Approved

CANCER

INJECTION; INTRAVENOUS

Leukemia, Promyelocytic, Acute; Lymphoma, Follicular; Graft vs Host Disease; Hematologic Diseases; Histiocytosis, Langerhans-Cell; Hodgkin Disease; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Osteopetrosis; Leukemia; Leukemia, Myeloid, Acute; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

DNA inhibitor

Small molecule

Approved

CANCER; HEMATOLOGY; OTHER

ORAL

Astrocytoma; Burkitt Lymphoma; Cachexia; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Lymphoma, Primary Effusion; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Kaposi; Urethral Neoplasms; Autistic Disorder; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Complex Regional Pain Syndromes; Crohn Disease; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Sinus; HIV Infections; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Plasma Cell; Leukemia, Prolymphocytic; Liver Neoplasms; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Pancreatic Neoplasms; POEMS Syndrome; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Radiculopathy; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia; Amyloidosis; Amyloidosis, Familial; Epstein-Barr Virus Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Neoplasms, Plasma Cell; Plasmacytoma; Prostatic Neoplasms, Castration-Resistant; Smoldering Multiple Myeloma; Anemia; Immune System Diseases; Lymphoma, Mantle-Cell; Multiple Myeloma; Myelodysplastic Syndromes

CRL4(CRBN) E3 ubiquitin ligase inhibitor

Small molecule

Approved

CANCER

INTRAVENOUS

Leukemia, Lymphoid; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms, Plasma Cell; Leukemia, Biphenotypic, Acute; Lymphoma; Mycosis Fungoides; Sezary Syndrome; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia-Lymphoma, Adult T-Cell; Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

DNA inhibitor

Antibody

Approved

CANCER; OTHER

IV (INFUSION)

Brain Neoplasms; Glioma; Kidney Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Cholangiocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Lung Neoplasms; Malignant Carcinoid Syndrome; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Head and Neck Neoplasms; Colorectal Neoplasms; Neoplasms

Epidermal growth factor receptor erbB1 inhibitor


Small molecule Approved CANCER; OTHER ORAL Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma Bcr/Abl fusion protein inhibitor

Small molecule

Approved

CANCER

SUBCUTANEOUS

beta-Thalassemia; Blood Platelet Disorders; Diabetes Mellitus, Type 1; Diabetic Foot; End Stage Liver Disease; Glioblastoma; Graft vs Host Disease; Kidney Diseases; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Myelodysplastic Syndromes; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Syndrome; Thalassemia; Anemia, Sickle Cell; Fanconi Anemia; Gliosarcoma; Granulomatous Disease, Chronic; Head and Neck Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell; Lymphopenia; Pancreatic Neoplasms; Scleroderma, Systemic; Hematopoietic Stem Cell Transplantation; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms

C-X-C chemokine receptor type 4 partial agonist

Small molecule

Approved

CANCER; IMMUNE SYSTEM; OTHER; UROLOGY AND KIDNEY

ORAL

Acute Coronary Syndrome; Adenocarcinoma; Aging; Breast Neoplasms, Male; Carcinoma, Ovarian Epithelial; Central Nervous System Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gastrointestinal Stromal Tumors; Hamartoma Syndrome, Multiple; Hematologic Diseases; Leukemia; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, Non-Hodgkin; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasms, Plasma Cell; Peritoneal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Progeria; Sarcoma, Synovial; Uterine Cervical Neoplasms; Adenoma, Islet Cell; Bile Duct Neoplasms; Brain Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Medullary; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Chondrosarcoma; Colonic Neoplasms; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Endometrial Neoplasms; Ependymoma; Epilepsy; Gallbladder Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hepatitis C; Hodgkin Disease; Hyperaldosteronism; Kidney Diseases; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Lymphangioleiomyomatosis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Mantle-Cell; Lymphoma, T-Cell, Cutaneous; Macular Degeneration; Mastocytosis, Systemic; Melanoma; Meningioma; Mesothelioma; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neurofibromatosis 1; Neurofibromatosis 2; Oligodendroglioma; Osteosarcoma; Ovarian Neoplasms; Paraganglioma; Peutz-Jeghers Syndrome; Polycystic Kidney Diseases; Sarcoma; Sarcoma, Kaposi; Small Cell Lung Carcinoma; Sturge-Weber Syndrome; Thymus Neoplasms; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Tuberculosis; Urinary Bladder Neoplasms; Uterine Neoplasms; Uveal Melanoma; Uveitis; Waldenstrom Macroglobulinemia; Carcinoid Tumor; Carcinoma; Coronary Disease; Coronary Restenosis; Cytomegalovirus Infections; Endocardial Cushion Defects; Graft vs Host Disease; Infections; Kidney Failure, Chronic; Kidney Neoplasms; Lymphoma, Large B-Cell, Diffuse; Malignant Carcinoid Syndrome; Polycystic Kidney, Autosomal Dominant; Prostatic Neoplasms, Castration-Resistant; Renal Insufficiency; Renal Insufficiency, Chronic; Skin Neoplasms; Stomach Neoplasms; Angiomyolipoma; Astrocytoma; Breast Neoplasms; Carcinoma, Renal Cell; Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Tuberous Sclerosis

FK506-binding protein 1A inhibitor

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS

Fallopian Tube Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Cutaneous; Multiple Myeloma; Mycosis Fungoides; Ovarian Neoplasms; Peritoneal Neoplasms; Sezary Syndrome; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lymphoma; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Neoplasms

Dihydrofolate reductase inhibitor


Small molecule Approved CANCER; DERMATOLOGY; OTHER TOPICAL Cheilitis; Molluscum Contagiosum; Warts; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Condylomata Acuminata; Keratosis; Keratosis, Seborrheic; Skin Diseases; Keratosis, Actinic Unknown

Antibody

Approved

CANCER; OTHER

INJECTION

Hematologic Neoplasms; HIV Infections; Leukemia; Leukemia, Myeloid, Acute; Enteropathy-Associated T-Cell Lymphoma; Graft vs Host Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Mast-Cell; Lupus Erythematosus, Systemic; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Mastocytosis, Systemic; Mesothelioma, Malignant; Neoplasms, Germ Cell and Embryonal; Scleroderma, Diffuse; Sezary Syndrome; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides; Hodgkin Disease; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms

Tubulin inhibitor