DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 51


Small molecule Approved CANCER; MUSCULOSKELETAL; OTHER; PREGNANCY AND GYNECOLOGY INJECTION; ORAL; TOPICAL; VAGINAL Reperfusion Injury; Brain Injuries; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Shock; Urinary Bladder, Overactive; Alzheimer Disease; Angina, Unstable; Anorexia Nervosa; Bone Diseases, Metabolic; Colonic Neoplasms; Coronary Disease; Diabetes Mellitus; Endometrial Hyperplasia; Endometrial Neoplasms; Hot Flashes; Hypercholesterolemia; Hypertension; Lupus Erythematosus, Systemic; Memory Disorders; Myocardial Infarction; Myocardial Ischemia; Stroke; Thrombosis; Turner Syndrome; Atrophic Vaginitis; Atrophy; Breast Neoplasms; Dyspareunia; Hypogonadism; Menopause; Osteoporosis; Osteoporosis, Postmenopausal; Primary Ovarian Insufficiency Estrogen receptor agonist

Small molecule

Approved

CANCER; MUSCULOSKELETAL; OTHER; PREGNANCY AND GYNECOLOGY

INJECTION; ORAL; TOPICAL; VAGINAL

Reperfusion Injury; Brain Injuries; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Shock; Urinary Bladder, Overactive; Alzheimer Disease; Angina, Unstable; Anorexia Nervosa; Bone Diseases, Metabolic; Colonic Neoplasms; Coronary Disease; Diabetes Mellitus; Endometrial Hyperplasia; Endometrial Neoplasms; Hot Flashes; Hypercholesterolemia; Hypertension; Lupus Erythematosus, Systemic; Memory Disorders; Myocardial Infarction; Myocardial Ischemia; Stroke; Thrombosis; Turner Syndrome; Atrophic Vaginitis; Atrophy; Breast Neoplasms; Dyspareunia; Hypogonadism; Menopause; Osteoporosis; Osteoporosis, Postmenopausal; Primary Ovarian Insufficiency

Estrogen receptor agonist


Small molecule Approved CANCER; OTHER INJECTION; ORAL; TOPICAL Hematologic Neoplasms; Arthritis, Rheumatoid; Crohn Disease; Epidermolysis Bullosa Acquisita; Pancreatic Neoplasms; Sezary Syndrome; Graft vs Host Disease; Lymphoma; Mycosis Fungoides; Lymphoma, T-Cell; Psoriasis DNA inhibitor


Small molecule Approved CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER BUCCAL; SUBLINGUAL; TRANSDERMAL Opioid-Related Disorders; Respiratory Distress Syndrome; Brain Injuries; Breast Neoplasms; Bronchial Spasm; Delirium; Fractures, Bone; Hypospadias; Hypotension; Irritable Bowel Syndrome; Pulpitis; Scoliosis; Subarachnoid Hemorrhage; Abscess; Adenoma; Diabetic Neuropathies; Liver Diseases; Low Back Pain; Neoplasm Metastasis; Obesity; Obesity, Morbid; Osteoarthritis; Pancreatic Neoplasms; Renal Insufficiency, Chronic; Respiratory Insufficiency; Sleep Apnea, Obstructive; Stomach Neoplasms; Acute Pain; Cancer Pain; Chronic Pain; Migraine Disorders; Neoplasms; Pain Mu opioid receptor agonist

Small molecule

Approved

CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

BUCCAL; SUBLINGUAL; TRANSDERMAL

Opioid-Related Disorders; Respiratory Distress Syndrome; Brain Injuries; Breast Neoplasms; Bronchial Spasm; Delirium; Fractures, Bone; Hypospadias; Hypotension; Irritable Bowel Syndrome; Pulpitis; Scoliosis; Subarachnoid Hemorrhage; Abscess; Adenoma; Diabetic Neuropathies; Liver Diseases; Low Back Pain; Neoplasm Metastasis; Obesity; Obesity, Morbid; Osteoarthritis; Pancreatic Neoplasms; Renal Insufficiency, Chronic; Respiratory Insufficiency; Sleep Apnea, Obstructive; Stomach Neoplasms; Acute Pain; Cancer Pain; Chronic Pain; Migraine Disorders; Neoplasms; Pain

Mu opioid receptor agonist


Protein Approved CANCER; HEMATOLOGY; OTHER UNKNOWN Peripheral Vascular Diseases; Alzheimer Disease; Blast Crisis; Carcinoma, Endometrioid; Chordoma; Coronary Disease; Cystadenoma, Serous; Enterocolitis, Necrotizing; Gliosarcoma; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Lymphoma, B-Cell, Marginal Zone; Menopause; Multiple Sclerosis; Muscular Diseases; Myasthenia Gravis; Neoplasm Metastasis; Neurilemmoma; Peripheral Arterial Disease; Primary Myelofibrosis; Sarcoma, Synovial; Severe Combined Immunodeficiency; Stiff-Person Syndrome; Vasculitis; Waldenstrom Macroglobulinemia; Amyotrophic Lateral Sclerosis; Anemia, Sickle Cell; Biliary Atresia; Breast Neoplasms, Male; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cardiomyopathy, Dilated; Cerebral Palsy; Colorectal Neoplasms; Crohn Disease; Diabetes Mellitus, Type 1; Epidermolysis Bullosa Dystrophica; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fanconi Anemia; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; HIV Infections; Infertility; Inflammatory Breast Neoplasms; Ischemic Stroke; Leukemia, Mast-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Lupus Erythematosus, Systemic; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Lymphopenia; Myelodysplastic-Myeloproliferative Diseases; Nasopharyngeal Neoplasms; Neuromyelitis Optica; Osteosarcoma; Pancreatic Neoplasms; Parkinson Disease; Pemphigus; Peritoneal Neoplasms; Prostatic Neoplasms; Red-Cell Aplasia, Pure; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Stroke; Urethral Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Adrenal Cortex Neoplasms; Amyloidosis, Familial; Anemia; Anemia, Aplastic; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Chagas Cardiomyopathy; Endometrial Neoplasms; Fever; Graft vs Host Disease; Head and Neck Neoplasms; Hepatitis, Alcoholic; Hodgkin Disease; Hot Flashes; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Diseases; Liver Failure; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mediastinal Neoplasms; Medulloblastoma; Melanoma; Mesenchymoma; Multiple Myeloma; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Myeloproliferative Disorders; Myocardial Infarction; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Ovarian Insufficiency; Prostatic Neoplasms, Castration-Resistant; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Scleroderma, Systemic; Testicular Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Infections; Neoplasms; Neutropenia Granulocyte colony stimulating factor receptor agonist

Protein

Approved

CANCER; HEMATOLOGY; OTHER

UNKNOWN

Peripheral Vascular Diseases; Alzheimer Disease; Blast Crisis; Carcinoma, Endometrioid; Chordoma; Coronary Disease; Cystadenoma, Serous; Enterocolitis, Necrotizing; Gliosarcoma; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Lymphoma, B-Cell, Marginal Zone; Menopause; Multiple Sclerosis; Muscular Diseases; Myasthenia Gravis; Neoplasm Metastasis; Neurilemmoma; Peripheral Arterial Disease; Primary Myelofibrosis; Sarcoma, Synovial; Severe Combined Immunodeficiency; Stiff-Person Syndrome; Vasculitis; Waldenstrom Macroglobulinemia; Amyotrophic Lateral Sclerosis; Anemia, Sickle Cell; Biliary Atresia; Breast Neoplasms, Male; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cardiomyopathy, Dilated; Cerebral Palsy; Colorectal Neoplasms; Crohn Disease; Diabetes Mellitus, Type 1; Epidermolysis Bullosa Dystrophica; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fanconi Anemia; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; HIV Infections; Infertility; Inflammatory Breast Neoplasms; Ischemic Stroke; Leukemia, Mast-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Lupus Erythematosus, Systemic; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Lymphopenia; Myelodysplastic-Myeloproliferative Diseases; Nasopharyngeal Neoplasms; Neuromyelitis Optica; Osteosarcoma; Pancreatic Neoplasms; Parkinson Disease; Pemphigus; Peritoneal Neoplasms; Prostatic Neoplasms; Red-Cell Aplasia, Pure; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Stroke; Urethral Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Adrenal Cortex Neoplasms; Amyloidosis, Familial; Anemia; Anemia, Aplastic; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Chagas Cardiomyopathy; Endometrial Neoplasms; Fever; Graft vs Host Disease; Head and Neck Neoplasms; Hepatitis, Alcoholic; Hodgkin Disease; Hot Flashes; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Diseases; Liver Failure; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mediastinal Neoplasms; Medulloblastoma; Melanoma; Mesenchymoma; Multiple Myeloma; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Myeloproliferative Disorders; Myocardial Infarction; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Ovarian Insufficiency; Prostatic Neoplasms, Castration-Resistant; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Scleroderma, Systemic; Testicular Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Infections; Neoplasms; Neutropenia

Granulocyte colony stimulating factor receptor agonist


Small molecule Approved CANCER; OTHER; RESPIRATORY INJECTION; IV (INFUSION) Anus Neoplasms; Brain Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Renal Cell; Carcinoma, Small Cell; Carcinoma, Verrucous; Coronary Restenosis; Genital Neoplasms, Female; Glioblastoma; Gliosarcoma; Hodgkin Disease; Hypopharyngeal Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Liver Neoplasms; Mesothelioma; Rectal Neoplasms; Vaginal Neoplasms; Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Adrenal Cortex Neoplasms; Arthritis, Rheumatoid; Biliary Tract Neoplasms; Breast Carcinoma In Situ; Carcinoma, Ductal; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Central Nervous System Neoplasms; Cervical Intraepithelial Neoplasia; Cholangiocarcinoma; Colorectal Neoplasms; Constriction, Pathologic; Cystadenoma, Serous; Digestive System Diseases; Gallbladder Neoplasms; Gastrointestinal Stromal Tumors; Hemangiosarcoma; Hereditary Breast and Ovarian Cancer Syndrome; Keratosis, Actinic; Kidney Neoplasms; Leukemia; Lymphoma; Mouth Neoplasms; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Oropharyngeal Neoplasms; Penile Neoplasms; Peripheral Vascular Diseases; Prostatic Hyperplasia; Prostatic Neoplasms; Psoriasis; Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Thymoma; Vulvar Neoplasms; Adenocarcinoma of Lung; Anemia; Breast Neoplasms, Male; Carcinoma, Endometrioid; Carcinoma, Large Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gestational Trophoblastic Disease; Head and Neck Neoplasms; HIV Infections; Hypersensitivity; Inflammatory Breast Neoplasms; Ischemia; Lung Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Pain; Pancreatic Neoplasms; Peripheral Arterial Disease; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Retroviridae Infections; Sarcoma; Sarcoma, Kaposi; Sex Cord-Gonadal Stromal Tumors; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Neoplasms Tubulin inhibitor

Small molecule

Approved

CANCER; OTHER; RESPIRATORY

INJECTION; IV (INFUSION)

Anus Neoplasms; Brain Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Renal Cell; Carcinoma, Small Cell; Carcinoma, Verrucous; Coronary Restenosis; Genital Neoplasms, Female; Glioblastoma; Gliosarcoma; Hodgkin Disease; Hypopharyngeal Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Liver Neoplasms; Mesothelioma; Rectal Neoplasms; Vaginal Neoplasms; Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Adrenal Cortex Neoplasms; Arthritis, Rheumatoid; Biliary Tract Neoplasms; Breast Carcinoma In Situ; Carcinoma, Ductal; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Central Nervous System Neoplasms; Cervical Intraepithelial Neoplasia; Cholangiocarcinoma; Colorectal Neoplasms; Constriction, Pathologic; Cystadenoma, Serous; Digestive System Diseases; Gallbladder Neoplasms; Gastrointestinal Stromal Tumors; Hemangiosarcoma; Hereditary Breast and Ovarian Cancer Syndrome; Keratosis, Actinic; Kidney Neoplasms; Leukemia; Lymphoma; Mouth Neoplasms; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Oropharyngeal Neoplasms; Penile Neoplasms; Peripheral Vascular Diseases; Prostatic Hyperplasia; Prostatic Neoplasms; Psoriasis; Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Thymoma; Vulvar Neoplasms; Adenocarcinoma of Lung; Anemia; Breast Neoplasms, Male; Carcinoma, Endometrioid; Carcinoma, Large Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gestational Trophoblastic Disease; Head and Neck Neoplasms; HIV Infections; Hypersensitivity; Inflammatory Breast Neoplasms; Ischemia; Lung Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Pain; Pancreatic Neoplasms; Peripheral Arterial Disease; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Retroviridae Infections; Sarcoma; Sarcoma, Kaposi; Sex Cord-Gonadal Stromal Tumors; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Neoplasms

Tubulin inhibitor


Protein Approved CANCER UNKNOWN Carcinoma, Non-Small-Cell Lung; Abortion, Habitual; Alopecia Areata; Anemia, Hemolytic, Autoimmune; Blast Crisis; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Colitis, Ulcerative; Colorectal Neoplasms; Coronary Disease; Cryoglobulinemia; Cytomegalovirus Infections; Encephalitis; Gliosarcoma; Hematologic Diseases; Hematologic Neoplasms; Hepatitis C; Macrophage Activation Syndrome; Mesothelioma; Mycosis Fungoides; Myelodysplastic-Myeloproliferative Diseases; Neoplasm Metastasis; Papillomavirus Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Sarcoma, Synovial; Sezary Syndrome; Squamous Intraepithelial Lesions; Thyroid Neoplasms; Wiskott-Aldrich Syndrome; Acquired Immunodeficiency Syndrome; Acute Coronary Syndrome; Behcet Syndrome; Breast Neoplasms, Male; Central Nervous System Neoplasms; Conjunctivitis, Allergic; Crohn Disease; Diabetes Mellitus, Type 1; Esophageal Neoplasms; Fallopian Tube Neoplasms; Graft vs Host Disease; Hodgkin Disease; Inflammatory Breast Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Lung Neoplasms; Lupus Erythematosus, Systemic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myeloproliferative Disorders; Myositis; Neoplasms; Nephrotic Syndrome; Ovarian Neoplasms; Pemphigus; Peritoneal Neoplasms; Polychondritis, Relapsing; Polymyalgia Rheumatica; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Urticaria; Amyotrophic Lateral Sclerosis; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Renal Cell; Head and Neck Neoplasms; HIV Infections; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Neuroblastoma; Severe Acute Respiratory Syndrome; Skin Neoplasms; Melanoma Interleukin-2 receptor agonist

Protein

Approved

CANCER

UNKNOWN

Carcinoma, Non-Small-Cell Lung; Abortion, Habitual; Alopecia Areata; Anemia, Hemolytic, Autoimmune; Blast Crisis; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Colitis, Ulcerative; Colorectal Neoplasms; Coronary Disease; Cryoglobulinemia; Cytomegalovirus Infections; Encephalitis; Gliosarcoma; Hematologic Diseases; Hematologic Neoplasms; Hepatitis C; Macrophage Activation Syndrome; Mesothelioma; Mycosis Fungoides; Myelodysplastic-Myeloproliferative Diseases; Neoplasm Metastasis; Papillomavirus Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Sarcoma, Synovial; Sezary Syndrome; Squamous Intraepithelial Lesions; Thyroid Neoplasms; Wiskott-Aldrich Syndrome; Acquired Immunodeficiency Syndrome; Acute Coronary Syndrome; Behcet Syndrome; Breast Neoplasms, Male; Central Nervous System Neoplasms; Conjunctivitis, Allergic; Crohn Disease; Diabetes Mellitus, Type 1; Esophageal Neoplasms; Fallopian Tube Neoplasms; Graft vs Host Disease; Hodgkin Disease; Inflammatory Breast Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Neoplasms; Lung Neoplasms; Lupus Erythematosus, Systemic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myeloproliferative Disorders; Myositis; Neoplasms; Nephrotic Syndrome; Ovarian Neoplasms; Pemphigus; Peritoneal Neoplasms; Polychondritis, Relapsing; Polymyalgia Rheumatica; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Urticaria; Amyotrophic Lateral Sclerosis; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Renal Cell; Head and Neck Neoplasms; HIV Infections; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Neuroblastoma; Severe Acute Respiratory Syndrome; Skin Neoplasms; Melanoma

Interleukin-2 receptor agonist


Small molecule Approved CANCER SUBCUTANEOUS; TRANSDERMAL Gastroparesis; Glioma; Leukemia, Mast-Cell; Lymphoma; Pruritus; Uterine Cervical Neoplasms; Vomiting; Nausea; Neoplasms; Postoperative Nausea and Vomiting Serotonin 3a (5-HT3a) receptor antagonist


Small molecule Approved CANCER; OTHER ORAL Hypertension; Aging; Endometrial Neoplasms; Kallmann Syndrome; Anovulation; Breast Neoplasms, Male; Carcinoma; Endometriosis; Fibrous Dysplasia, Polyostotic; Hypertension, Pulmonary; Hypogonadism; Hypopituitarism; Metabolic Syndrome; Ovarian Neoplasms; Peritoneal Neoplasms; Puberty, Precocious; Triple Negative Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; Gynecomastia; Breast Neoplasms; Neoplasms Cytochrome P450 19A1 inhibitor

Small molecule

Approved

CANCER; OTHER

ORAL

Hypertension; Aging; Endometrial Neoplasms; Kallmann Syndrome; Anovulation; Breast Neoplasms, Male; Carcinoma; Endometriosis; Fibrous Dysplasia, Polyostotic; Hypertension, Pulmonary; Hypogonadism; Hypopituitarism; Metabolic Syndrome; Ovarian Neoplasms; Peritoneal Neoplasms; Puberty, Precocious; Triple Negative Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; Gynecomastia; Breast Neoplasms; Neoplasms

Cytochrome P450 19A1 inhibitor


Unknown Approved CANCER ORAL Unknown Unknown


Small molecule Approved CANCER; OTHER; PREGNANCY AND GYNECOLOGY INJECTION; INTRAVENOUS Breast Neoplasms, Male; Carcinoma, Endometrioid; Carcinoma, Renal Cell; Colonic Neoplasms; Cystadenoma, Serous; Digestive System Diseases; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Nausea; Sarcoma, Synovial; Vaginal Neoplasms; Vulvar Neoplasms; Adenocarcinoma; Anus Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Neuroendocrine; Carcinoma, Transitional Cell; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hereditary Breast and Ovarian Cancer Syndrome; Leiomyosarcoma; Leukemia; Liver Neoplasms; Mediastinal Neoplasms; Melanoma; Osteosarcoma; Pancreatic Neoplasms; Penile Neoplasms; Retroviridae Infections; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Testicular Neoplasms; Thyroid Carcinoma, Anaplastic; Tonsillar Neoplasms; Triple Negative Breast Neoplasms; Uterine Neoplasms; Adenocarcinoma of Lung; Anorexia; Cachexia; Carcinoma; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fatigue; Genital Neoplasms, Male; Head and Neck Neoplasms; Hypersensitivity; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neutropenia; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paranasal Sinus Neoplasms; Peritoneal Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Stomach Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms Tubulin inhibitor

Small molecule

Approved

CANCER; OTHER; PREGNANCY AND GYNECOLOGY

INJECTION; INTRAVENOUS

Breast Neoplasms, Male; Carcinoma, Endometrioid; Carcinoma, Renal Cell; Colonic Neoplasms; Cystadenoma, Serous; Digestive System Diseases; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Nausea; Sarcoma, Synovial; Vaginal Neoplasms; Vulvar Neoplasms; Adenocarcinoma; Anus Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Neuroendocrine; Carcinoma, Transitional Cell; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hereditary Breast and Ovarian Cancer Syndrome; Leiomyosarcoma; Leukemia; Liver Neoplasms; Mediastinal Neoplasms; Melanoma; Osteosarcoma; Pancreatic Neoplasms; Penile Neoplasms; Retroviridae Infections; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Testicular Neoplasms; Thyroid Carcinoma, Anaplastic; Tonsillar Neoplasms; Triple Negative Breast Neoplasms; Uterine Neoplasms; Adenocarcinoma of Lung; Anorexia; Cachexia; Carcinoma; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fatigue; Genital Neoplasms, Male; Head and Neck Neoplasms; Hypersensitivity; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neutropenia; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paranasal Sinus Neoplasms; Peritoneal Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Stomach Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms

Tubulin inhibitor


Small molecule Approved CANCER; OTHER ORAL Carcinoma, Merkel Cell; Central Nervous System Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Urinary Bladder Neoplasms; Anus Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Pancreatic Ductal; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Lung Neoplasms; Mesothelioma; Oropharyngeal Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Brain Diseases; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Gallbladder Neoplasms; Hand-Foot Syndrome; Liver Neoplasms; Nasopharyngeal Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Stomach Neoplasms; Breast Neoplasms; Colonic Neoplasms; Neoplasms DNA inhibitor

Small molecule

Approved

CANCER; OTHER

ORAL

Carcinoma, Merkel Cell; Central Nervous System Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Urinary Bladder Neoplasms; Anus Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Pancreatic Ductal; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Lung Neoplasms; Mesothelioma; Oropharyngeal Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Brain Diseases; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Gallbladder Neoplasms; Hand-Foot Syndrome; Liver Neoplasms; Nasopharyngeal Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Stomach Neoplasms; Breast Neoplasms; Colonic Neoplasms; Neoplasms

DNA inhibitor


Small molecule Approved CANCER; OTHER INTRAVENOUS; ORAL Desmoplastic Small Round Cell Tumor; Cytomegalovirus Infections; Ependymoma; Fallopian Tube Neoplasms; Meningitis, Aseptic; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Biliary Tract Neoplasms; Brain Diseases; Brain Stem Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Colorectal Neoplasms; Ganglioneuroblastoma; Gastrointestinal Stromal Tumors; Glioma; Hereditary Breast and Ovarian Cancer Syndrome; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Medulloblastoma; Myelodysplastic Syndromes; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Neurofibromatosis 1; Ovarian Neoplasms; Pancreatic Neoplasms; Pinealoma; Pituitary Neoplasms; Rectal Neoplasms; Retinoblastoma; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Spinal Cord Neoplasms; Astrocytoma; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Choroid Plexus Neoplasms; Diffuse Intrinsic Pontine Glioma; Gliosarcoma; Melanoma; Neoplasm Metastasis; Neuroendocrine Tumors; Oligodendroglioma; Optic Nerve Glioma; Sarcoma, Ewing; Glioblastoma; Neoplasms DNA inhibitor

Small molecule

Approved

CANCER; OTHER

INTRAVENOUS; ORAL

Desmoplastic Small Round Cell Tumor; Cytomegalovirus Infections; Ependymoma; Fallopian Tube Neoplasms; Meningitis, Aseptic; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Biliary Tract Neoplasms; Brain Diseases; Brain Stem Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Colorectal Neoplasms; Ganglioneuroblastoma; Gastrointestinal Stromal Tumors; Glioma; Hereditary Breast and Ovarian Cancer Syndrome; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Medulloblastoma; Myelodysplastic Syndromes; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Neurofibromatosis 1; Ovarian Neoplasms; Pancreatic Neoplasms; Pinealoma; Pituitary Neoplasms; Rectal Neoplasms; Retinoblastoma; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Spinal Cord Neoplasms; Astrocytoma; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Choroid Plexus Neoplasms; Diffuse Intrinsic Pontine Glioma; Gliosarcoma; Melanoma; Neoplasm Metastasis; Neuroendocrine Tumors; Oligodendroglioma; Optic Nerve Glioma; Sarcoma, Ewing; Glioblastoma; Neoplasms

DNA inhibitor


Antibody Approved CANCER INJECTION; SINGLE-DOSE Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelomonocytic, Juvenile; Leukemia, Promyelocytic, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Leukemia, Myeloid; Neoplasms DNA inhibitor


Antibody Approved CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER INJECTION; INTRAVENOUS Neoplasms, Neuroepithelial; Anemia; Arthritis, Rheumatoid; Fallopian Tube Neoplasms; Fanconi Anemia; Kidney Diseases; Leukemia, Prolymphocytic, T-Cell; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Renal Insufficiency; Vasculitis; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; beta-Thalassemia; Crohn Disease; Diabetes Mellitus, Type 1; Graft vs Host Disease; Granulomatous Disease, Chronic; Hematologic Neoplasms; Hemoglobinopathies; Histiocytosis; Hodgkin Disease; Kidney Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphoid; Leukemia, Prolymphocytic; Liver Diseases; Lymphoma, Large B-Cell, Diffuse; Mycosis Fungoides; Myeloproliferative Disorders; Myositis, Inclusion Body; Neoplasms; Osteopetrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Renal Insufficiency, Chronic; Severe Combined Immunodeficiency; Sezary Syndrome; Thalassemia; Waldenstrom Macroglobulinemia; Anemia, Sickle Cell; Granuloma, Lethal Midline; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, T-Cell, Peripheral; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Immune System Diseases; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Sclerosis CAMPATH-1 antigen inhibitor

Antibody

Approved

CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

INJECTION; INTRAVENOUS

Neoplasms, Neuroepithelial; Anemia; Arthritis, Rheumatoid; Fallopian Tube Neoplasms; Fanconi Anemia; Kidney Diseases; Leukemia, Prolymphocytic, T-Cell; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Renal Insufficiency; Vasculitis; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; beta-Thalassemia; Crohn Disease; Diabetes Mellitus, Type 1; Graft vs Host Disease; Granulomatous Disease, Chronic; Hematologic Neoplasms; Hemoglobinopathies; Histiocytosis; Hodgkin Disease; Kidney Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphoid; Leukemia, Prolymphocytic; Liver Diseases; Lymphoma, Large B-Cell, Diffuse; Mycosis Fungoides; Myeloproliferative Disorders; Myositis, Inclusion Body; Neoplasms; Osteopetrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Renal Insufficiency, Chronic; Severe Combined Immunodeficiency; Sezary Syndrome; Thalassemia; Waldenstrom Macroglobulinemia; Anemia, Sickle Cell; Granuloma, Lethal Midline; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, T-Cell, Peripheral; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Immune System Diseases; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Sclerosis

CAMPATH-1 antigen inhibitor


Small molecule Approved CANCER; DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER INJECTION; INTRAVENOUS; IV (INFUSION) Adenocarcinoma; Anemia, Sickle Cell; Chondrosarcoma; Menopause; Neuroblastoma; beta-Thalassemia; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Renal Cell; Complex Regional Pain Syndromes; Kidney Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Low Back Pain; Macular Degeneration; Mesothelioma; Nasopharyngeal Neoplasms; Osteosarcoma; Primary Myelofibrosis; Progeria; Urogenital Neoplasms; Uterine Cervical Neoplasms; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Bone Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Fractures, Bone; Giant Cell Tumors; Lung Neoplasms; Lymphoma, Non-Hodgkin; Osteoarthritis, Hip; Osteogenesis Imperfecta; Osteonecrosis; Pain; Plasmacytoma; Reflex Sympathetic Dystrophy; Sarcoma; Sarcoma, Ewing; Spinal Cord Injuries; Bone Diseases; Multiple Myeloma; Neoplasm Metastasis; Osteitis Deformans; Osteoporosis; Osteoporosis, Postmenopausal; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant Farnesyl diphosphate synthase inhibitor

Small molecule

Approved

CANCER; DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER

INJECTION; INTRAVENOUS; IV (INFUSION)

Adenocarcinoma; Anemia, Sickle Cell; Chondrosarcoma; Menopause; Neuroblastoma; beta-Thalassemia; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Renal Cell; Complex Regional Pain Syndromes; Kidney Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Low Back Pain; Macular Degeneration; Mesothelioma; Nasopharyngeal Neoplasms; Osteosarcoma; Primary Myelofibrosis; Progeria; Urogenital Neoplasms; Uterine Cervical Neoplasms; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Bone Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Fractures, Bone; Giant Cell Tumors; Lung Neoplasms; Lymphoma, Non-Hodgkin; Osteoarthritis, Hip; Osteogenesis Imperfecta; Osteonecrosis; Pain; Plasmacytoma; Reflex Sympathetic Dystrophy; Sarcoma; Sarcoma, Ewing; Spinal Cord Injuries; Bone Diseases; Multiple Myeloma; Neoplasm Metastasis; Osteitis Deformans; Osteoporosis; Osteoporosis, Postmenopausal; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant

Farnesyl diphosphate synthase inhibitor


Enzyme Approved CANCER INTRAVENOUS Burkitt Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hyperuricemia; Tumor Lysis Syndrome; Gout; Leukemia; Lymphoma Uric acid oxidative enzyme


Protein Approved CANCER UNKNOWN Brain Neoplasms; Lymphoma, T-Cell, Cutaneous; Medulloblastoma; Neuroblastoma; Osteosarcoma; Adenocarcinoma of Lung; Anemia, Aplastic; Breast Neoplasms, Male; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Melanoma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Retinoblastoma; Small Cell Lung Carcinoma; Stomach Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Hodgkin Disease; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Sarcoma; Triple Negative Breast Neoplasms; Uterine Neoplasms; Infections; Neoplasms; Neutropenia Granulocyte colony stimulating factor receptor agonist

Protein

Approved

CANCER

UNKNOWN

Brain Neoplasms; Lymphoma, T-Cell, Cutaneous; Medulloblastoma; Neuroblastoma; Osteosarcoma; Adenocarcinoma of Lung; Anemia, Aplastic; Breast Neoplasms, Male; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Melanoma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Retinoblastoma; Small Cell Lung Carcinoma; Stomach Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Hodgkin Disease; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Sarcoma; Triple Negative Breast Neoplasms; Uterine Neoplasms; Infections; Neoplasms; Neutropenia

Granulocyte colony stimulating factor receptor agonist


Antibody Approved CANCER INJECTION Burkitt Lymphoma; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, AIDS-Related; Lymphoma, B-Cell, Marginal Zone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Waldenstrom Macroglobulinemia; Graft vs Host Disease; Leukemia; Lymphoma; Lymphoma, Mantle-Cell; Multiple Myeloma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin B-lymphocyte antigen CD20 binding agent

Antibody

Approved

CANCER

INJECTION

Burkitt Lymphoma; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, AIDS-Related; Lymphoma, B-Cell, Marginal Zone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Waldenstrom Macroglobulinemia; Graft vs Host Disease; Leukemia; Lymphoma; Lymphoma, Mantle-Cell; Multiple Myeloma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin

B-lymphocyte antigen CD20 binding agent


Small molecule Approved CANCER; OTHER INJECTION; INTRAVENOUS Carcinoid Tumor; Digestive System Diseases; Gastrointestinal Stromal Tumors; Gliosarcoma; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Diseases; Lymphoma, T-Cell, Cutaneous; Melanoma; Myelodysplastic Syndromes; Neuroblastoma; Anus Neoplasms; Breast Neoplasms; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Digestive System Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lymphoma, Follicular; Mesothelioma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma; Adenocarcinoma, Mucinous; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Signet Ring Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Esophageal Neoplasms; Granuloma, Lethal Midline; Hepatoblastoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasm Metastasis; Neuroendocrine Tumors; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Neoplasms DNA inhibitor

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS

Carcinoid Tumor; Digestive System Diseases; Gastrointestinal Stromal Tumors; Gliosarcoma; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Diseases; Lymphoma, T-Cell, Cutaneous; Melanoma; Myelodysplastic Syndromes; Neuroblastoma; Anus Neoplasms; Breast Neoplasms; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Digestive System Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lymphoma, Follicular; Mesothelioma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma; Adenocarcinoma, Mucinous; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Signet Ring Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Esophageal Neoplasms; Granuloma, Lethal Midline; Hepatoblastoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasm Metastasis; Neuroendocrine Tumors; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Neoplasms

DNA inhibitor


Small molecule Approved CANCER INTRAMUSCULAR Carcinoma, Ductal; Carcinoma, Squamous Cell; Colorectal Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Lymphoma; Lymphoma, Non-Hodgkin; Mesothelioma; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Fibrous Dysplasia, Polyostotic; Genital Neoplasms, Female; Hypertension, Pulmonary; Lung Neoplasms; Lupus Erythematosus, Systemic; Ovarian Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma, Endometrial Stromal; Uterine Neoplasms; Carcinoma, Lobular; Neoplasm Metastasis; Breast Neoplasms; Neoplasms Estrogen receptor antagonist

Small molecule

Approved

CANCER

INTRAMUSCULAR

Carcinoma, Ductal; Carcinoma, Squamous Cell; Colorectal Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Lymphoma; Lymphoma, Non-Hodgkin; Mesothelioma; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Fibrous Dysplasia, Polyostotic; Genital Neoplasms, Female; Hypertension, Pulmonary; Lung Neoplasms; Lupus Erythematosus, Systemic; Ovarian Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma, Endometrial Stromal; Uterine Neoplasms; Carcinoma, Lobular; Neoplasm Metastasis; Breast Neoplasms; Neoplasms

Estrogen receptor antagonist


Small molecule Approved CANCER; GASTROINTESTINAL; OTHER INTRAVENOUS; ORAL Glioblastoma; Heroin Dependence; HIV Infections; Opioid-Related Disorders; Alcoholism; Cocaine-Related Disorders; Gastroparesis; Leukemia, Myeloid, Acute; Marijuana Abuse; Pain; Pruritus; Severe Acute Respiratory Syndrome; Carcinoma, Non-Small-Cell Lung; Depressive Disorder, Major; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Vomiting; Nausea; Neoplasms; Postoperative Nausea and Vomiting Neurokinin 1 receptor antagonist

Small molecule

Approved

CANCER; GASTROINTESTINAL; OTHER

INTRAVENOUS; ORAL

Glioblastoma; Heroin Dependence; HIV Infections; Opioid-Related Disorders; Alcoholism; Cocaine-Related Disorders; Gastroparesis; Leukemia, Myeloid, Acute; Marijuana Abuse; Pain; Pruritus; Severe Acute Respiratory Syndrome; Carcinoma, Non-Small-Cell Lung; Depressive Disorder, Major; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Vomiting; Nausea; Neoplasms; Postoperative Nausea and Vomiting

Neurokinin 1 receptor antagonist


Protein Approved CANCER INTRAMUSCULAR Prostatic Neoplasms, Castration-Resistant; Neoplasms Gonadotropin-releasing hormone receptor antagonist


Small molecule Approved CANCER INJECTION; INTRAVENOUS; SUBCUTANEOUS; UNKNOWN Myeloproliferative Disorders; Anemia, Refractory, with Excess of Blasts; Astrocytoma; Burkitt Lymphoma; Carcinoma, Medullary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Glioblastoma; Immunoblastic Lymphadenopathy; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Muscular Dystrophies; Mycosis Fungoides; Neuroblastoma; Oligodendroglioma; Peritoneal Neoplasms; Sezary Syndrome; Smoldering Multiple Myeloma; Uremia; Adenocarcinoma, Bronchiolo-Alveolar; Adenocarcinoma, Follicular; Adenocarcinoma of Lung; Breast Neoplasms; Bronchiolitis Obliterans; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Castleman Disease; Central Nervous System Neoplasms; Colorectal Neoplasms; Encephalitis, Japanese; Esophageal Neoplasms; Glioma; Gliosarcoma; Graft vs Host Disease; Head and Neck Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Immune System Diseases; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Lung Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Lymphoproliferative Disorders; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neuromyelitis Optica; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Red-Cell Aplasia, Pure; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Amyloidosis; Amyloidosis, Familial; Cholangiocarcinoma; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Plasmacytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Renal Insufficiency, Chronic; Sarcoma, Myeloid; Waldenstrom Macroglobulinemia; Lymphoma, Mantle-Cell; Multiple Myeloma; Neoplasms 26S proteosome inhibitor

Small molecule

Approved

CANCER

INJECTION; INTRAVENOUS; SUBCUTANEOUS; UNKNOWN

Myeloproliferative Disorders; Anemia, Refractory, with Excess of Blasts; Astrocytoma; Burkitt Lymphoma; Carcinoma, Medullary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Glioblastoma; Immunoblastic Lymphadenopathy; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Muscular Dystrophies; Mycosis Fungoides; Neuroblastoma; Oligodendroglioma; Peritoneal Neoplasms; Sezary Syndrome; Smoldering Multiple Myeloma; Uremia; Adenocarcinoma, Bronchiolo-Alveolar; Adenocarcinoma, Follicular; Adenocarcinoma of Lung; Breast Neoplasms; Bronchiolitis Obliterans; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Castleman Disease; Central Nervous System Neoplasms; Colorectal Neoplasms; Encephalitis, Japanese; Esophageal Neoplasms; Glioma; Gliosarcoma; Graft vs Host Disease; Head and Neck Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Immune System Diseases; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Lung Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Lymphoproliferative Disorders; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neuromyelitis Optica; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Red-Cell Aplasia, Pure; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Amyloidosis; Amyloidosis, Familial; Cholangiocarcinoma; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Plasmacytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Renal Insufficiency, Chronic; Sarcoma, Myeloid; Waldenstrom Macroglobulinemia; Lymphoma, Mantle-Cell; Multiple Myeloma; Neoplasms

26S proteosome inhibitor


Small molecule Approved CANCER ORAL Carcinoma, Renal Cell; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Breast Neoplasms, Male; Carcinoma; Carcinoma, Hepatocellular; Central Nervous System Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Gliosarcoma; Kidney Neoplasms; Leukemia, Myeloid, Acute; Mesothelioma; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Salivary Gland Neoplasms; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Urethral Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Lung Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms Epidermal growth factor receptor erbB1 inhibitor

Small molecule

Approved

CANCER

ORAL

Carcinoma, Renal Cell; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Breast Neoplasms, Male; Carcinoma; Carcinoma, Hepatocellular; Central Nervous System Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Gliosarcoma; Kidney Neoplasms; Leukemia, Myeloid, Acute; Mesothelioma; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Salivary Gland Neoplasms; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Urethral Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Lung Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms

Epidermal growth factor receptor erbB1 inhibitor


Small molecule Approved CANCER; OTHER INJECTION; INTRAVENOUS; IV (INFUSION) Glioma; Chordoma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Meningeal Carcinomatosis; Thymoma; Thymus Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Medulloblastoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms Unknown

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS; IV (INFUSION)

Glioma; Chordoma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Meningeal Carcinomatosis; Thymoma; Thymus Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Medulloblastoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms

Unknown

Small molecule

Approved

CANCER

INJECTION; INTRAVENOUS

Leukemia, Promyelocytic, Acute; Lymphoma, Follicular; Lymphoma, T-Cell; Graft vs Host Disease; Hematologic Diseases; Histiocytosis, Langerhans-Cell; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Osteopetrosis; Leukemia; Leukemia, Myeloid, Acute; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

DNA inhibitor

Small molecule

Approved

CANCER; HEMATOLOGY; OTHER

ORAL

Astrocytoma; Burkitt Lymphoma; Cachexia; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Kaposi; Urethral Neoplasms; Amyloidosis; Autistic Disorder; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Complex Regional Pain Syndromes; Crohn Disease; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Sinus; HIV Infections; Hodgkin Disease; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Plasma Cell; Leukemia, Prolymphocytic; Liver Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Pancreatic Neoplasms; POEMS Syndrome; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Radiculopathy; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia; Amyloidosis, Familial; Epstein-Barr Virus Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Plasmacytoma; Prostatic Neoplasms, Castration-Resistant; Smoldering Multiple Myeloma; Anemia; Immune System Diseases; Lymphoma, Mantle-Cell; Multiple Myeloma; Myelodysplastic Syndromes

CRL4(CRBN) E3 ubiquitin ligase inhibitor


Small molecule Approved CANCER INTRAVENOUS Leukemia, Lymphoid; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Leukemia; Leukemia, Biphenotypic, Acute; Lymphoma; Mycosis Fungoides; Sezary Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia-Lymphoma, Adult T-Cell; Neoplasms DNA inhibitor

Antibody

Approved

CANCER; OTHER

IV (INFUSION)

Kidney Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Cholangiocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Lung Neoplasms; Malignant Carcinoid Syndrome; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Head and Neck Neoplasms; Colorectal Neoplasms; Neoplasms

Epidermal growth factor receptor erbB1 inhibitor

Small molecule

Approved

CANCER; OTHER

ORAL

Endometrial Neoplasms; Alzheimer Disease; Brain Neoplasms; Burkitt Lymphoma; Central Nervous System Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Head and Neck Neoplasms; Hodgkin Disease; Idiopathic Pulmonary Fibrosis; Immunoblastic Lymphadenopathy; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myeloid; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Myelodysplastic Syndromes; Ovarian Neoplasms; Peritoneal Neoplasms; Rhabdomyosarcoma; Scleroderma, Localized; Sezary Syndrome; Waldenstrom Macroglobulinemia; Aging; Brain Diseases; Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Gastrointestinal Stromal Tumors; Glioblastoma; Glioma; Gliosarcoma; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lung Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Mastocytosis, Systemic; Melanoma; Mesothelioma; Multiple Myeloma; Neuroblastoma; Pancreatic Neoplasms; Pinealoma; Polycythemia Vera; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Small Cell Lung Carcinoma; Leukemia; Leukemia, Myeloid, Acute; Prostatic Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Bcr/Abl fusion protein

Small molecule

Approved

CANCER

SUBCUTANEOUS

Diabetes Mellitus, Type 1; Diabetic Foot; End Stage Liver Disease; Graft vs Host Disease; Kidney Diseases; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Myelodysplastic Syndromes; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Thalassemia; Anemia, Sickle Cell; Fanconi Anemia; Gliosarcoma; Granulomatous Disease, Chronic; Head and Neck Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell; Lymphopenia; Neoplasms; Pancreatic Neoplasms; Scleroderma, Systemic; Lymphoma, Non-Hodgkin; Multiple Myeloma

C-X-C chemokine receptor type 4 partial agonist

Small molecule

Approved

CANCER; IMMUNE SYSTEM; OTHER; UROLOGY AND KIDNEY

ORAL

Acute Coronary Syndrome; Adenocarcinoma; Breast Neoplasms, Male; Central Nervous System Neoplasms; Colonic Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Gastrointestinal Stromal Tumors; Hamartoma Syndrome, Multiple; Hematologic Diseases; Leukemia; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, Non-Hodgkin; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Peritoneal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Progeria; Sarcoma, Synovial; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms; Adenoma, Islet Cell; Brain Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Medullary; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Chondrosarcoma; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Endometrial Hyperplasia; Endometrial Neoplasms; Ependymoma; Epilepsy; Glioblastoma; Glioma; Head and Neck Neoplasms; Hepatitis C; Hodgkin Disease; Hyperaldosteronism; Kidney Diseases; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Lymphangioleiomyomatosis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Mantle-Cell; Lymphoma, T-Cell, Cutaneous; Macular Degeneration; Mastocytosis, Systemic; Melanoma; Meningioma; Mesothelioma; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neurofibromatosis 1; Neurofibromatosis 2; Oligodendroglioma; Osteosarcoma; Pancreatic Neoplasms; Peutz-Jeghers Syndrome; Polycystic Kidney Diseases; Sarcoma; Sarcoma, Kaposi; Small Cell Lung Carcinoma; Thymus Neoplasms; Thyroid Neoplasms; Tuberculosis; Urinary Bladder Neoplasms; Uterine Neoplasms; Uveitis; Waldenstrom Macroglobulinemia; Carcinoid Tumor; Carcinoma; Coronary Restenosis; Cytomegalovirus Infections; Endocardial Cushion Defects; Graft vs Host Disease; Infections; Kidney Neoplasms; Lymphoma, Large B-Cell, Diffuse; Malignant Carcinoid Syndrome; Polycystic Kidney, Autosomal Dominant; Prostatic Neoplasms, Castration-Resistant; Renal Insufficiency; Renal Insufficiency, Chronic; Skin Neoplasms; Stomach Neoplasms; Angiomyolipoma; Astrocytoma; Breast Neoplasms; Carcinoma, Renal Cell; Immune System Diseases; Neoplasms; Neuroendocrine Tumors; Tuberous Sclerosis

FK506-binding protein 1A inhibitor

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS

Fallopian Tube Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Cutaneous; Multiple Myeloma; Mycosis Fungoides; Ovarian Neoplasms; Peritoneal Neoplasms; Sezary Syndrome; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lymphoma; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Neoplasms

Dihydrofolate reductase inhibitor


Small molecule Approved CANCER; DERMATOLOGY; OTHER TOPICAL Molluscum Contagiosum; Cheilitis; Warts; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Condylomata Acuminata; Keratosis; Keratosis, Seborrheic; Lentigo; Skin Diseases; Keratosis, Actinic Unknown

Antibody

Approved

CANCER; OTHER

INJECTION

Hematologic Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Enteropathy-Associated T-Cell Lymphoma; Graft vs Host Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Mast-Cell; Lupus Erythematosus, Systemic; Lymphoma; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Mesothelioma; Neoplasms, Germ Cell and Embryonal; Scleroderma, Diffuse; Sezary Syndrome; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Hodgkin Disease; Lymphoma, Large-Cell, Anaplastic; Neoplasms

Tubulin inhibitor