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Total: 19
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER; RHEUMATOLOGY
ORAL
Osteomyelitis; Glioblastoma; Hypertension, Pulmonary; Intestinal Obstruction; Nausea; Cholangitis, Sclerosing; Peripheral Nervous System Diseases; Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative
Arachidonate 5-lipoxygenase inhibitor
Small molecule
Approved
MUSCULOSKELETAL; OTHER; RHEUMATOLOGY
ORAL
Liver Cirrhosis; Acute Coronary Syndrome; Amyotrophic Lateral Sclerosis; Behcet Syndrome; Cholangiocarcinoma; Coronary Disease; Diabetic Nephropathies; Heart Diseases; Hepatitis C, Chronic; Hypertension; Myocardial Infarction; Osteoarthritis; Pneumonia, Viral; Prostatic Neoplasms, Castration-Resistant; Renal Insufficiency, Chronic; Stomatitis, Aphthous; Vascular Diseases; Arrhythmias, Cardiac; Asthma; Atrial Fibrillation; Heart Failure; Liver Cirrhosis, Biliary; Lung Diseases; Non-ST Elevated Myocardial Infarction; Pericarditis; Postpericardiotomy Syndrome; Severe Acute Respiratory Syndrome; ST Elevation Myocardial Infarction; Vasculitis; Vitreoretinopathy, Proliferative; Familial Mediterranean Fever; Gout
Tubulin inhibitor
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER; PREGNANCY AND GYNECOLOGY; RHEUMATOLOGY
ORAL; TOPICAL; TRANSDERMAL; VAGINAL
Cerebral Arterial Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; HIV Infections; Osteoporosis; Polycystic Ovary Syndrome; Aging; Alzheimer Disease; Atherosclerosis; Bulimia Nervosa; Carcinoid Tumor; Depression, Postpartum; Depressive Disorder; Dry Eye Syndromes; Hereditary Breast and Ovarian Cancer Syndrome; Migraine Disorders; Prostatic Neoplasms; Psychotic Disorders; Schizophrenia; Severe Acute Respiratory Syndrome; Amenorrhea; Anorexia Nervosa; Atrophic Vaginitis; Atrophy; Bone Diseases, Metabolic; Breast Neoplasms; Dysmenorrhea; Endometriosis; Hot Flashes; Infertility; Leiomyoma; Menopause; Multiple Sclerosis; Myocardial Ischemia; Non-alcoholic Fatty Liver Disease; Obesity; Pain; Prostatic Neoplasms, Castration-Resistant; Sexual Dysfunction, Physiological; Stress Disorders, Post-Traumatic; Turner Syndrome; Dyspareunia; Hypogonadism; Primary Ovarian Insufficiency
Estrogen receptor alpha agonist
Small molecule
Approved
MUSCULOSKELETAL; OTHER; RHEUMATOLOGY
ORAL
Kidney Calculi; Renal Colic; Paget Disease, Extramammary; Periodontitis; Bursitis; Inflammation; Low Back Pain; Migraine Disorders; Osteoarthritis, Knee; Postoperative Nausea and Vomiting; Sprains and Strains; Tendinopathy; Wounds and Injuries; Acute Pain; Arthralgia; Arthritis, Rheumatoid; Dysmenorrhea; Myalgia; Osteoarthritis; Pain; Rheumatic Diseases
Cyclooxygenase inhibitor
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER; RHEUMATOLOGY
ORAL
Lecithin Cholesterol Acyltransferase Deficiency; Carcinoma, Hepatocellular; Pancreatic Neoplasms; Colorectal Neoplasms; Muscular Diseases; Pain; Sprains and Strains; Acute Pain; Arthritis, Juvenile; Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases
Cyclooxygenase-2 inhibitor
Protein
Approved
OTHER; RHEUMATOLOGY
SUBCUTANEOUS; UNKNOWN
Fanconi Anemia; Myositis, Inclusion Body; HIV Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic Syndromes; Neoplasms; Persian Gulf Syndrome; Prostatic Neoplasms, Castration-Resistant; Sciatica; Subarachnoid Hemorrhage; Alzheimer Disease; Amyloidosis; Asthma; Dermatomyositis; Granulomatosis with Polyangiitis; Hidradenitis Suppurativa; Histiocytosis; Leukemia; Lichen Planus; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Metabolic Syndrome; Mucocutaneous Lymph Node Syndrome; Pemphigus; Pulmonary Disease, Chronic Obstructive; Pulmonary Fibrosis; Radiculopathy; Renal Insufficiency, Chronic; Reperfusion Injury; Sjogren's Syndrome; Stomatitis; Synovitis; Temporomandibular Joint Disorders; Tinnitus; Urticaria; Vitiligo; Anorexia; Arthritis; Cachexia; Diabetes Mellitus, Type 1; Graft vs Host Disease; Inflammation; Pneumonia; Polymyalgia Rheumatica; Stevens-Johnson Syndrome; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Immune System Diseases; Psoriasis; Spondylitis; Spondylitis, Ankylosing
TNF-alpha inhibitor
Antibody
Approved
RHEUMATOLOGY
UNKNOWN
Berylliosis; Granulomatous Disease, Chronic; Arthritis, Reactive; Bipolar Disorder; Colitis; Dermatomyositis; Diabetes Mellitus, Type 1; Endometriosis; Eosinophilic Esophagitis; Giant Cell Arteritis; Granulomatosis with Polyangiitis; Hepatitis C; Hidradenitis Suppurativa; Microscopic Polyangiitis; Myelodysplastic Syndromes; Myositis; Osteoarthritis; Paraparesis, Tropical Spastic; Pemphigus; Reperfusion Injury; Spondylarthropathies; Stevens-Johnson Syndrome; Takayasu Arteritis; Wet Macular Degeneration; Anorexia; Arthritis, Juvenile; Behcet Syndrome; Cachexia; Fatigue; Graft vs Host Disease; Hepatitis C, Chronic; Inflammatory Bowel Diseases; Low Back Pain; Lung Neoplasms; Mucocutaneous Lymph Node Syndrome; Parapsoriasis; Polymyalgia Rheumatica; Pulmonary Disease, Chronic Obstructive; Sarcoidosis; Scleritis; Severe Acute Respiratory Syndrome; Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Immune System Diseases; Psoriasis; Spondylitis, Ankylosing
TNF-alpha inhibitor
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER; RHEUMATOLOGY
ORAL
Breast Neoplasms; Graft vs Host Disease; HIV Infections; Melanoma; Severe Acute Respiratory Syndrome; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Multiple Myeloma; Pemphigoid, Bullous; Prostatic Neoplasms, Castration-Resistant; Purpura, Schoenlein-Henoch; Smoldering Multiple Myeloma; Uveitis; Arthritis, Psoriatic; Central Nervous System Neoplasms; Lupus Nephritis; Myasthenia Gravis; Polymyalgia Rheumatica; Arthritis, Rheumatoid; Immune System Diseases; Multiple Sclerosis
Dihydroorotate dehydrogenase inhibitor
Small molecule
Approved
MUSCULOSKELETAL; OTHER; RHEUMATOLOGY
ORAL
Brain Neoplasms; Glioma; Alzheimer Disease; Carcinoma, Non-Small-Cell Lung; Adenoma; Colorectal Neoplasms; Joint Diseases; Osteoarthritis; Osteoarthritis, Knee; Pain; Prostatic Neoplasms, Castration-Resistant; Stomach Neoplasms; Rheumatic Diseases
Cyclooxygenase-2 inhibitor
Protein
Approved
OTHER; RHEUMATOLOGY
SUBCUTANEOUS
Endometriosis; Granulomatous Disease, Chronic; Asthma; Blepharitis; Breast Neoplasms; Hearing Loss; HIV Infections; Hypertension, Pulmonary; Knee Injuries; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Sclerosis; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Smoldering Multiple Myeloma; Amyotrophic Lateral Sclerosis; Arthritis, Juvenile; Brain Injuries; Cerebral Hemorrhage; Dermatomyositis; Diabetes Mellitus; Diabetes Mellitus, Type 1; Fatigue Syndrome, Chronic; Gout; Heart Failure; Hepatitis, Alcoholic; Hidradenitis Suppurativa; Infections; Labyrinth Diseases; Lymphoma, Follicular; Macrophage Activation Syndrome; Multiple Myeloma; Myocarditis; Myositis, Inclusion Body; Osteoarthritis; Pericarditis; Polycystic Ovary Syndrome; Renal Insufficiency, Chronic; Sarcoidosis; Still's Disease, Adult-Onset; Uveitis; Familial Mediterranean Fever; Giant Cell Arteritis; Metabolic Syndrome; Mucocutaneous Lymph Node Syndrome; Myocardial Infarction; Severe Acute Respiratory Syndrome; Arthritis, Rheumatoid; Cryopyrin-Associated Periodic Syndromes; Immune System Diseases
Interleukin-1 receptor antagonist
Enzyme
Approved
RHEUMATOLOGY
IV (INFUSION)
Mucopolysaccharidoses; Mucopolysaccharidosis II
Heparan sulfate hydrolytic enzyme
Protein
Approved
RHEUMATOLOGY
IV (INFUSION)
Behcet Syndrome; Myasthenia Gravis; Polychondritis, Relapsing; Vitiligo; Alopecia; Alopecia Areata; Diabetes Mellitus, Type 1; Graft vs Host Disease; Hypertension; Immunoglobulin G4-Related Disease; Lupus Erythematosus, Systemic; Multiple Myeloma; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Nephrotic Syndrome; Peanut Hypersensitivity; Psoriasis; Sarcoidosis; Scleroderma, Diffuse; Spondylitis, Ankylosing; Takayasu Arteritis; Uveitis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Colitis, Ulcerative; Crohn Disease; Dermatomyositis; Giant Cell Arteritis; Granulomatosis with Polyangiitis; Lupus Nephritis; Polymyalgia Rheumatica; Severe Acute Respiratory Syndrome; Sjogren's Syndrome; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Immune System Diseases
T-lymphocyte activation antigen CD80 inhibitor
Antibody
Approved
RHEUMATOLOGY
INJECTION
Colitis, Ulcerative; Arthritis, Juvenile; Cystitis, Interstitial; Psoriasis; Arthritis, Psoriatic; Arthritis, Rheumatoid; Crohn Disease; Immune System Diseases; Inflammation; Spondylitis, Ankylosing
TNF-alpha inhibitor
Antibody
Approved
OTHER; RHEUMATOLOGY
INJECTION
Labyrinth Diseases; Asthma; Diabetes Mellitus, Type 1; Sarcoidosis; Arthritis, Juvenile; Osteoarthritis; Spondylarthropathies; Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Immune System Diseases; Spondylitis; Spondylitis, Ankylosing
TNF-alpha inhibitor
Antibody
Approved
RHEUMATOLOGY
SUBCUTANEOUS
Carcinoma, Renal Cell; Breast Neoplasms; Carcinoma, Pancreatic Ductal; Macular Degeneration; Myelodysplastic Syndromes; Pulmonary Disease, Chronic Obstructive; Anemia, Sickle Cell; Aortic Aneurysm, Abdominal; Arthritis, Rheumatoid; Atrial Fibrillation; Behcet Syndrome; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dry Eye Syndromes; Hepatitis, Alcoholic; Lung Neoplasms; Melanoma; Mucocutaneous Lymph Node Syndrome; Osteoarthritis; Peripheral Arterial Disease; Polymyalgia Rheumatica; Pyoderma; Sarcoidosis, Pulmonary; Schnitzler Syndrome; Urticaria; Atherosclerosis; Carcinoma, Non-Small-Cell Lung; Fever; Gout; Pneumonia; Severe Acute Respiratory Syndrome; Still's Disease, Adult-Onset; Arthritis, Juvenile; Cryopyrin-Associated Periodic Syndromes; Familial Mediterranean Fever; Immune System Diseases; Mevalonate Kinase Deficiency
Interleukin-1 beta inhibitor
Enzyme
Approved
RHEUMATOLOGY
INJECTION
Renal Insufficiency, Chronic; Gout
Uric acid oxidative enzyme
Small molecule
Approved
DERMATOLOGY; IMMUNE SYSTEM; OTHER; RHEUMATOLOGY
ORAL; UNKNOWN
Stomatitis, Aphthous; Lupus Erythematosus, Discoid; Uveitis; Acne Vulgaris; Alcoholism; Arthritis, Rheumatoid; Colitis, Ulcerative; Dermatitis; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dermatomyositis; Eczema; Gout; Hidradenitis Suppurativa; Lichen Planus; Lichen Planus, Oral; Prostatitis; Rosacea; Vitiligo; Behcet Syndrome; Severe Acute Respiratory Syndrome; Spondylitis, Ankylosing; Arthritis, Psoriatic; Immune System Diseases; Oral Ulcer; Psoriasis
Phosphodiesterase 4 inhibitor
Combination
Approved
MUSCULOSKELETAL; OTHER; RHEUMATOLOGY
ORAL
Unknown
Unknown
Combination
Approved
GASTROINTESTINAL; OTHER; RHEUMATOLOGY
ORAL
Unknown
Unknown