| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1982) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt Prodrug |
| UNII: | 927L42J563 |
| Parent Compound: | ACYCLOVIR |
Structure
| InChI Key | RMLUKZWYIKEASN-UHFFFAOYSA-M |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C8H10N5NaO3 |
| Molecular Weight | 247.19 |
| AlogP | -0.92 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 119.31 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 16.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Human herpesvirus 1 DNA polymerase inhibitor | FDA |
Metabolites
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Herpes Labialis | 3 | D006560 | ClinicalTrials |
| Cytomegalovirus Infections | 3 | D003586 | ClinicalTrials |
| Infections | 3 | D007239 | ClinicalTrials |
| Multiple Sclerosis | 3 | D009103 | ClinicalTrials |
| Neoplasms | 3 | D009369 | ClinicalTrials |
| Keratitis, Herpetic | 3 | D016849 | ClinicalTrials |
| Herpes Simplex | 3 | D006561 | ClinicalTrials |
| HIV Infections | 2 | D015658 | ClinicalTrials |
| Carcinoma, Non-Small-Cell Lung | 2 | D002289 | ClinicalTrials |
| Prostatic Neoplasms, Castration-Resistant | 2 | D064129 | ClinicalTrials |
| Meniere Disease | 2 | D008575 | ClinicalTrials |
| Kidney Diseases | 1 | D007674 | ClinicalTrials |
| Leukemia, Biphenotypic, Acute | 1 | D015456 | ClinicalTrials |
| Lymphoma, Large B-Cell, Diffuse | 1 | D016403 | ClinicalTrials |
Related Entries
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL1200380 |
| FDA SRS | 927L42J563 |
| PubChem | 23665721 |
| SureChEMBL | SCHEMBL40722 |
CONTENTS