| Trade Names: | |
| Synonyms: | |
| Status: | Approved (2002) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN Prodrug |
| ATC: | J05AF08 |
| UNII: | U6Q8Z01514 |
Structure
| InChI Key | WOZSCQDILHKSGG-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C20H32N5O8P |
| Molecular Weight | 501.48 |
| AlogP | 2.7 |
| Hydrogen Bond Acceptor | 13.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 11.0 |
| Polar Surface Area | 166.98 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 34.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC22 family of organic cation and anion transporters
|
- | 13500 | - | - | - | |
|
Transporter
Primary active transporter
ATP-binding cassette
ABCB subfamily
|
- | 46000 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| HIV Infections | 3 | D015658 | ClinicalTrials |
| Cytomegalovirus Infections | 3 | D003586 | ClinicalTrials |
Related Entries
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 142340-99-6 |
| ChEBI | 31175 |
| ChEMBL | CHEMBL922 |
| DrugBank | DB00718 |
| DrugCentral | 88 |
| EPA CompTox | DTXSID5046487 |
| FDA SRS | U6Q8Z01514 |
| Human Metabolome Database | HMDB0014856 |
| PharmGKB | PA10005 |
| PubChem | 60871 |
| SureChEMBL | SCHEMBL29729 |
| ZINC | ZINC000003930376 |
CONTENTS