AFLIBERCEPT

Search structure
Trade Names:
Synonyms:
Status: Approved (2011)
Entry Type: Protein
Molecule Category: UNKNOWN
ATC: L01XX44
UNII: 15C2VL427D

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Placenta growth factor inhibitor DailyMed DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Macular Degeneration 4 D008268 ClinicalTrials
Colorectal Neoplasms 4 D015179 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Macular Degeneration 4 D008268 ClinicalTrials
Colorectal Neoplasms 4 D015179 ClinicalTrials
Retinal Vein Occlusion 3 D012170 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Glaucoma 3 D005901 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Myopia, Degenerative 3 D047728 ClinicalTrials
Glaucoma, Neovascular 3 D015355 ClinicalTrials
Retinopathy of Prematurity 3 D012178 ClinicalTrials
Telangiectasis 3 D013684 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Carcinoma, Renal Cell 2 D002292 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Astrocytoma 2 D001254 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Graves Ophthalmopathy 2 D049970 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Retinal Diseases 2 D012164 ClinicalTrials
Adenocarcinoma, Follicular 2 D018263 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Urethral Neoplasms 2 D014523 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Gliosarcoma 2 D018316 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Pseudoxanthoma Elasticum 2 D011561 ClinicalTrials
Vitreous Hemorrhage 2 D014823 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Central Serous Chorioretinopathy 2 D056833 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 1 D002289 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Lymphoma 1 D008223 ClinicalTrials
Histoplasmosis 1 D006660 ClinicalTrials
Corneal Neovascularization 1 D016510 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Eye disorders
29.59
General disorders and administration site conditions
21.16
Nervous system disorders
12.13
Injury, poisoning and procedural complications
8.27
Vascular disorders
7.59
Infections and infestations
3.84
Surgical and medical procedures
2.44
Cardiac disorders
2.25

Cross References

Resources Reference
CAS NUMBER 862111-32-8
ChEMBL CHEMBL1742982
FDA SRS 15C2VL427D
Guide to Pharmacology 6786
CONTENTS