ALDESLEUKIN

Search structure
Trade Names:
Synonyms:
Status: Approved (1992)
Entry Type: Protein
Molecule Category: UNKNOWN
ATC: L03AC01
UNII: M89N0Q7EQR

Pharmacology

Action Mechanism of Action Reference
AGONIST Interleukin-2 receptor agonist

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Melanoma 4 D008545 ClinicalTrials
Melanoma 4 D008545 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Leukemia, Myeloid, Acute 3 D015470 ClinicalTrials
Leukemia 3 D007938 ClinicalTrials
Anemia, Refractory, with Excess of Blasts 3 D000754 ClinicalTrials
Anemia, Refractory 3 D000753 ClinicalTrials
Leukemia, Myelomonocytic, Chronic 3 D015477 ClinicalTrials
Leukemia, Erythroblastic, Acute 3 D004915 ClinicalTrials
Lupus Erythematosus, Systemic 3 D008180 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
HIV Infections 3 D015658 ClinicalTrials
HIV Infections 3 D015658 ClinicalTrials
Myelodysplastic Syndromes 3 D009190 ClinicalTrials
Leukemia, Monocytic, Acute 3 D007948 ClinicalTrials
Leukemia, Myelomonocytic, Acute 3 D015479 ClinicalTrials
Burkitt Lymphoma 3 D002051 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Dermatomyositis 3 D003882 ClinicalTrials
Skin Neoplasms 3 D012878 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Leukemia, Megakaryoblastic, Acute 3 D007947 ClinicalTrials
Leukemia, Myeloid, Acute 3 D015470 ClinicalTrials
Leukemia, Basophilic, Acute 3 D015471 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Neuroblastoma 3 D009447 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Peritoneal Neoplasms 2 D010534 ClinicalTrials
Nephrotic Syndrome 2 D009404 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 2 D015464 ClinicalTrials
Crohn Disease 2 D003424 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Lymphoma, Non-Hodgkin 2 D008228 ClinicalTrials
Breast Neoplasms, Male 2 D018567 ClinicalTrials
Inflammatory Breast Neoplasms 2 D058922 ClinicalTrials
Myositis 2 D009220 ClinicalTrials
Behcet Syndrome 2 D001528 ClinicalTrials
Myeloproliferative Disorders 2 D009196 ClinicalTrials
Polymyalgia Rheumatica 2 D011111 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Polychondritis, Relapsing 2 D011081 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 2 D015451 ClinicalTrials
Myeloproliferative Disorders 2 D009196 ClinicalTrials
Central Nervous System Neoplasms 2 D016543 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Liver Neoplasms 2 D008113 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Conjunctivitis, Allergic 2 D003233 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Alzheimer Disease 2 D000544 ClinicalTrials
Amyotrophic Lateral Sclerosis 2 D000690 ClinicalTrials
Diabetes Mellitus, Type 1 2 D003922 ClinicalTrials
Bronchiolitis Obliterans Syndrome 2 D000092122 ClinicalTrials
Uveal Melanoma 2 D000098943 ClinicalTrials
Uveal Melanoma 2 D000098943 ClinicalTrials
Sezary Syndrome 1 D012751 ClinicalTrials
Myocardial Ischemia 1 D017202 ClinicalTrials
Cryoglobulinemia 1 D003449 ClinicalTrials
Carcinoma, Hepatocellular 1 D006528 ClinicalTrials
Alopecia Areata 1 D000506 ClinicalTrials
Brain Neoplasms 1 D001932 ClinicalTrials
Leukemia, Biphenotypic, Acute 1 D015456 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 1 D002289 ClinicalTrials
Encephalitis 1 D004660 ClinicalTrials
Squamous Intraepithelial Lesions 1 D000081483 ClinicalTrials
Hematologic Neoplasms 1 D019337 ClinicalTrials
Carcinoma, Squamous Cell 1 D002294 ClinicalTrials
Papillomavirus Infections 1 D030361 ClinicalTrials
Glioblastoma 1 D005909 ClinicalTrials
Sarcoma 1 D012509 ClinicalTrials
Acquired Immunodeficiency Syndrome 1 D000163 ClinicalTrials
Sarcoma, Synovial 1 D013584 ClinicalTrials
Myelodysplastic-Myeloproliferative Diseases 1 D054437 ClinicalTrials
Pancreatic Neoplasms 1 D010190 ClinicalTrials
Mesothelioma 1 D008654 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials
Uterine Cervical Neoplasms 1 D002583 ClinicalTrials
Abortion, Habitual 1 D000026 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 1 D016410 ClinicalTrials
Gliosarcoma 1 D018316 ClinicalTrials
Colorectal Neoplasms 1 D015179 ClinicalTrials
Macrophage Activation Syndrome 1 D055501 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Cytomegalovirus Infections 1 D003586 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Carcinoma, Merkel Cell 1 D015266 ClinicalTrials
Anemia, Hemolytic, Autoimmune 1 D000744 ClinicalTrials
Blast Crisis 1 D001752 ClinicalTrials
Wiskott-Aldrich Syndrome 1 D014923 ClinicalTrials
Adenocarcinoma of Lung 1 D000077192 ClinicalTrials
Mycosis Fungoides 1 D009182 ClinicalTrials
Thyroid Neoplasms 1 D013964 ClinicalTrials
Carcinoma, Squamous Cell 1 D002294 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
12.75
Nervous system disorders
9.1
Investigations
7.13
Vascular disorders
6.98
Gastrointestinal disorders
6.83
Cardiac disorders
6.68
Immune system disorders
6.37
Skin and subcutaneous tissue disorders
5.61
Metabolism and nutrition disorders
5.31
Renal and urinary disorders
5.01
Blood and lymphatic system disorders
4.7
Respiratory, thoracic and mediastinal disorders
4.25
Psychiatric disorders
3.95
Musculoskeletal and connective tissue disorders
3.64
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
3.49
Injury, poisoning and procedural complications
3.03

Cross References

Resources Reference
CAS NUMBER 110942-02-4
ChEMBL CHEMBL1201438
FDA SRS M89N0Q7EQR
CONTENTS