| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1995) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN Prodrug |
| ATC: | V03AF05 |
| UNII: | ILA426L95O |
Structure
| InChI Key | JKOQGQFVAUAYPM-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C5H15N2O3PS |
| Molecular Weight | 214.23 |
| AlogP | -0.25 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 4.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 95.58 |
| Molecular species | ZWITTERION |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 12.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| None | Reactive metabolite scavenging agent | DailyMed |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Head and Neck Neoplasms | 4 | D006258 | ClinicalTrials |
| Ovarian Neoplasms | 4 | D010051 | ClinicalTrials |
| Hepatoblastoma | 3 | D018197 | ClinicalTrials |
| Peripheral Nervous System Diseases | 3 | D010523 | ClinicalTrials |
| Carcinoma, Squamous Cell | 3 | D002294 | ClinicalTrials |
| Multiple Myeloma | 3 | D009101 | ClinicalTrials |
| Trigeminal Neuralgia | 3 | D014277 | ClinicalTrials |
| Lung Neoplasms | 3 | D008175 | ClinicalTrials |
| Nasopharyngeal Neoplasms | 3 | D009303 | ClinicalTrials |
| Myelodysplastic Syndromes | 2 | D009190 | ClinicalTrials |
| Prostatic Neoplasms | 2 | D011471 | ClinicalTrials |
| Rectal Neoplasms | 2 | D012004 | ClinicalTrials |
| Leukemia | 2 | D007938 | ClinicalTrials |
| Hodgkin Disease | 2 | D006689 | ClinicalTrials |
| Lymphoma | 2 | D008223 | ClinicalTrials |
| Lymphoma, Non-Hodgkin | 2 | D008228 | ClinicalTrials |
| Colorectal Neoplasms | 2 | D015179 | ClinicalTrials |
| Sarcoma | 2 | D012509 | ClinicalTrials |
| Central Nervous System Neoplasms | 2 | D016543 | ClinicalTrials |
| Urinary Bladder Neoplasms | 2 | D001749 | ClinicalTrials |
| Peritoneal Neoplasms | 2 | D010534 | ClinicalTrials |
| Fallopian Tube Neoplasms | 2 | D005185 | ClinicalTrials |
| Uterine Cervical Neoplasms | 2 | D002583 | ClinicalTrials |
| Breast Neoplasms | 2 | D001943 | ClinicalTrials |
| Prostatic Neoplasms, Castration-Resistant | 2 | D064129 | ClinicalTrials |
| Endometrial Neoplasms | 2 | D016889 | ClinicalTrials |
| Fanconi Anemia | 1 | D005199 | ClinicalTrials |
| Neoplasms, Germ Cell and Embryonal | 1 | D009373 | ClinicalTrials |
| Mesothelioma | 1 | D008654 | ClinicalTrials |
| Myeloproliferative Disorders | 1 | D009196 | ClinicalTrials |
| Chordoma | 1 | D002817 | ClinicalTrials |
| Retinoblastoma | 1 | D012175 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Neuroblastoma | 1 | D009447 | ClinicalTrials |
| Leukemia, Myeloid, Acute | 1 | D015470 | ClinicalTrials |
| Kidney Neoplasms | 1 | D007680 | ClinicalTrials |
| Liver Neoplasms | 1 | D008113 | ClinicalTrials |
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 20537-88-6 |
| ChEBI | 2636 |
| ChEMBL | CHEMBL1006 |
| DrugBank | DB01143 |
| DrugCentral | 156 |
| EPA CompTox | DTXSID8022585 |
| FDA SRS | ILA426L95O |
| Human Metabolome Database | HMDB0015274 |
| KEGG | C06819 |
| PharmGKB | PA448365 |
| PubChem | 148139 |
| SureChEMBL | SCHEMBL18464 |
| ZINC | ZINC000021992285 |
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