| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1961) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt |
| UNII: | 26LUD4JO9K |
| Parent Compound: | AMITRIPTYLINE |
Structure
| InChI Key | KFYRPLNVJVHZGT-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C20H24ClN |
| Molecular Weight | 313.87 |
| AlogP | 4.17 |
| Hydrogen Bond Acceptor | 1.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 3.24 |
| Molecular species | BASE |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 21.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Norepinephrine transporter inhibitor | DailyMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 53 |
Metabolites
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Pruritus | 2 | D011537 | ClinicalTrials |
| Peripheral Nervous System Diseases | 2 | D010523 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 2667 |
| ChEMBL | CHEMBL1200964 |
| EPA CompTox | DTXSID9033187 |
| FDA SRS | 26LUD4JO9K |
| Guide to Pharmacology | 200 |
| KEGG | C06824 |
| PDB | TP0 |
| PubChem | 11065 |
| SureChEMBL | SCHEMBL41079 |
| ZINC | ZINC00968257 |
CONTENTS