ASPARAGINASE

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Trade Names:	ELSPAR
Synonyms:	Asparaginase Colaspase Crasnitin E. coli asparaginase E. coli l-asparaginase Elspar Escherichia coli l-asparaginase Kidrolase L-asparaginase L-asparagine amidohydrolase NSC-109229
Status:	Approved (1994)
Entry Type:	Enzyme
Molecule Category:	UNKNOWN
ATC:	L01XX02
UNII:	G4FQ3CKY5R

Action	Mechanism of Action	Reference
HYDROLYTIC ENZYME	Asparagine hydrolytic enzyme	DailyMed

Mesh Heading	Maximum Phase	Mesh ID	Reference
Precursor Cell Lymphoblastic Leukemia-Lymphoma	4	D054198	ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma	4	D054198	ClinicalTrials
Leukemia	3	D007938	ClinicalTrials
Myeloproliferative Disorders	3	D009196	ClinicalTrials
Lymphoma, Non-Hodgkin	3	D008228	ClinicalTrials
Sarcoma, Myeloid	3	D023981	ClinicalTrials
Leukemia, Erythroblastic, Acute	3	D004915	ClinicalTrials
Leukemia, Myelomonocytic, Acute	3	D015479	ClinicalTrials
Leukemia, Megakaryoblastic, Acute	3	D007947	ClinicalTrials
Leukemia, Myeloid, Acute	3	D015470	ClinicalTrials
Anemia, Refractory	3	D000753	ClinicalTrials
Anemia, Refractory, with Excess of Blasts	3	D000754	ClinicalTrials
Leukemia, Myelomonocytic, Chronic	3	D015477	ClinicalTrials
Leukemia, Monocytic, Acute	3	D007948	ClinicalTrials
Lymphoma	3	D008223	ClinicalTrials
Myelodysplastic Syndromes	3	D009190	ClinicalTrials
Leukemia, Myeloid, Acute	3	D015470	ClinicalTrials
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3	D054218	ClinicalTrials
Leukemia, Basophilic, Acute	3	D015471	ClinicalTrials
Leukemia, Biphenotypic, Acute	2	D015456	ClinicalTrials
Leukemia, Lymphoid	2	D007945	ClinicalTrials
Leukemia, Biphenotypic, Acute	2	D015456	ClinicalTrials
Leukemia, Biphenotypic, Acute	2	D015456	ClinicalTrials

System Organ Classification (SOC)

	Relative Frequency (%)
Immune system disorders	42.51
Vascular disorders	11.19
Blood and lymphatic system disorders	5.82
Gastrointestinal disorders	5.37
Infections and infestations	5.37
Injury, poisoning and procedural complications	5.37
Investigations	3.36
Neoplasms benign, malignant and unspecified (incl cysts and polyps)	3.36
General disorders and administration site conditions	3.13
Respiratory, thoracic and mediastinal disorders	3.13
Pregnancy, puerperium and perinatal conditions	2.91
Hepatobiliary disorders	2.01

CONTENTS


Active Pharmaceutical Ingredients (APIs) Scaffolds	Exact Similarity SubStructure	Threshold (%) >= 70