AVATROMBOPAG MALEATE

Search structure
Trade Names:
Synonyms:
Status: Approved (2018)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: GDW7M2P1IS

Structure
InChI Key MISPBGHDNZYFNM-BTJKTKAUSA-N
Smile O=C(Nc1nc(-c2cc(Cl)cs2)c(N2CCN(C3CCCCC3)CC2)s1)c1cnc(N2CCC(C(=O)O)CC2)c(Cl)c1.O=C(O)/C=C\C(=O)O
InChI
InChI=1S/C29H34Cl2N6O3S2.C4H4O4/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40;5-3(6)1-2-4(7)8/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38);1-2H,(H,5,6)(H,7,8)/b;2-1-

Physicochemical Descriptors

Property Name Value
Molecular Formula C33H38Cl2N6O7S2
Molecular Weight 765.74
AlogP 6.58
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 101.9
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 42.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Thrombopoietin receptor agonist FDA FDA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Thrombocytopenia 4 D013921 FDA

Related Entries

MCS

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
21.83
Gastrointestinal disorders
15.34
Nervous system disorders
13.86
Injury, poisoning and procedural complications
8.55
Vascular disorders
7.37
Investigations
6.49
Cardiac disorders
6.19
Psychiatric disorders
4.13
Skin and subcutaneous tissue disorders
3.24
Respiratory, thoracic and mediastinal disorders
2.95
Musculoskeletal and connective tissue disorders
2.65
Hepatobiliary disorders
2.06

Cross References

Resources Reference
ChEMBL CHEMBL2105758
FDA SRS GDW7M2P1IS
PharmGKB PA166179849
PubChem 9918581
SureChEMBL SCHEMBL19610454
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