AVELUMAB

Search structure
Trade Names:
Synonyms:
Status: Approved (2017)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L01XC31
UNII: KXG2PJ551I

Pharmacology

Action Mechanism of Action Reference
OTHER Programmed cell death 1 ligand 1 other PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Colonic Neoplasms 3 D003110 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Urogenital Neoplasms 3 D014565 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Leiomyosarcoma 2 D007890 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Hemangiosarcoma 2 D006394 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Carcinoma, Adenoid Cystic 2 D003528 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Neuroendocrine Tumors 2 D018358 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Adenocarcinoma 2 D000230 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Gestational Trophoblastic Disease 2 D031901 ClinicalTrials
Skin Neoplasms 1 D012878 ClinicalTrials
Lymphoma, Follicular 1 D008224 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Mesothelioma 1 D008654 ClinicalTrials
Melanoma 1 D008545 ClinicalTrials
Meningioma 1 D008579 ClinicalTrials
Prostatic Neoplasms 1 D011471 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1 D015464 ClinicalTrials
Head and Neck Neoplasms 1 D006258 ClinicalTrials
Chordoma 1 D002817 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Peritoneal Neoplasms 1 D010534 ClinicalTrials
Fallopian Tube Neoplasms 1 D005185 ClinicalTrials
Lymphoma, Follicular 1 D008224 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Carcinoma, Pancreatic Ductal 0 D021441 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
17.67
Nervous system disorders
8.97
Respiratory, thoracic and mediastinal disorders
7.56
Injury, poisoning and procedural complications
6.63
Immune system disorders
6.36
Investigations
6.22
Cardiac disorders
6.16
Gastrointestinal disorders
5.96
Musculoskeletal and connective tissue disorders
4.42
Vascular disorders
4.22
Psychiatric disorders
4.02
Metabolism and nutrition disorders
3.15
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
2.95
Infections and infestations
2.81
Skin and subcutaneous tissue disorders
2.81
Hepatobiliary disorders
2.34

Cross References

Resources Reference
CAS NUMBER 1537032-82-8
ChEMBL CHEMBL3833373
FDA SRS KXG2PJ551I
Guide to Pharmacology 8735
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