| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1996) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt |
| UNII: | 0L591QR10I |
| Parent Compound: | AZELASTINE |
Structure
| InChI Key | YEJAJYAHJQIWNU-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H25Cl2N3O |
| Molecular Weight | 418.37 |
| AlogP | 4.3 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 38.13 |
| Molecular species | BASE |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 27.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Histamine H1 receptor antagonist | FDA |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 135 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Rhinitis, Vasomotor | 4 | D012223 | ClinicalTrials |
| Rhinitis, Allergic, Seasonal | 4 | D006255 | ClinicalTrials |
| Common Cold | 3 | D003139 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 2951 |
| ChEMBL | CHEMBL1200809 |
| EPA CompTox | DTXSID2045945 |
| FDA SRS | 0L591QR10I |
| Guide to Pharmacology | 7121 |
| KEGG | C07768 |
| PubChem | 54360 |
| SureChEMBL | SCHEMBL36770 |
| ZINC | ZINC00897240 |
CONTENTS