Physicochemical Descriptors

Property Name Value
Molecular Formula C26H31Cl2N5O4
Molecular Weight 548.47
AlogP 5.19
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 9.0
Polar Surface Area 82.88
Molecular species None
Aromatic Rings 3.0
Heavy Atoms 36.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Bcr/Abl fusion protein inhibitor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 4 D015464 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
Gastrointestinal disorders
21.4
General disorders and administration site conditions
13.16
Investigations
7.8
Respiratory, thoracic and mediastinal disorders
7.37
Nervous system disorders
6.56
Cardiac disorders
5.73
Musculoskeletal and connective tissue disorders
5.7
Skin and subcutaneous tissue disorders
5.6
Vascular disorders
4.06
Infections and infestations
3.65
Metabolism and nutrition disorders
3.09
Injury, poisoning and procedural complications
2.95
Psychiatric disorders
2.7
Blood and lymphatic system disorders
2.08