CANAKINUMAB

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Trade Names:
Synonyms:
Status: Approved (2009)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L04AC08
UNII: 37CQ2C7X93

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Interleukin-1 beta inhibitor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Cryopyrin-Associated Periodic Syndromes 4 D056587 ClinicalTrials
Gout 3 D006073 ClinicalTrials
Still's Disease, Adult-Onset 3 D016706 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Fever 3 D005334 ClinicalTrials
Atherosclerosis 3 D050197 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Pneumonia 3 D011014 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Systemic Inflammatory Response Syndrome 3 D018746 ClinicalTrials
Hypoglycemia 3 D007003 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Chronic Urticaria 2 D000080223 ClinicalTrials
Pyoderma 2 D011711 ClinicalTrials
Arthritis, Rheumatoid 2 D001172 ClinicalTrials
Aortic Aneurysm, Abdominal 2 D017544 ClinicalTrials
Peripheral Arterial Disease 2 D058729 ClinicalTrials
Atrial Fibrillation 2 D001281 ClinicalTrials
Sarcoidosis, Pulmonary 2 D017565 ClinicalTrials
Dry Eye Syndromes 2 D015352 ClinicalTrials
Mucocutaneous Lymph Node Syndrome 2 D009080 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Polymyalgia Rheumatica 2 D011111 ClinicalTrials
Hepatitis, Alcoholic 2 D006519 ClinicalTrials
Behcet Syndrome 2 D001528 ClinicalTrials
Schnitzler Syndrome 2 D019873 ClinicalTrials
Diabetes Mellitus, Type 1 2 D003922 ClinicalTrials
Diabetes Mellitus, Type 2 2 D003924 ClinicalTrials
Osteoarthritis 2 D010003 ClinicalTrials
Anemia, Sickle Cell 2 D000755 ClinicalTrials
Osteoarthritis, Knee 2 D020370 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials
Pulmonary Disease, Chronic Obstructive 1 D029424 ClinicalTrials
Carcinoma, Renal Cell 1 D002292 ClinicalTrials
Macular Degeneration 1 D008268 ClinicalTrials
Carcinoma, Pancreatic Ductal 1 D021441 ClinicalTrials
Myelodysplastic Syndromes 1 D009190 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
15.56
Infections and infestations
12.14
Respiratory, thoracic and mediastinal disorders
11.57
Gastrointestinal disorders
9.76
Musculoskeletal and connective tissue disorders
6.81
Investigations
6.16
Skin and subcutaneous tissue disorders
5.16
Nervous system disorders
4.99
Injury, poisoning and procedural complications
4.94
Immune system disorders
3.03
Vascular disorders
2.85
Cardiac disorders
2.41
Blood and lymphatic system disorders
2.31
Metabolism and nutrition disorders
2.26
Psychiatric disorders
2.16

Cross References

Resources Reference
CAS NUMBER 914613-48-2
ChEMBL CHEMBL1201834
FDA SRS 37CQ2C7X93
Guide to Pharmacology 6773
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