CARBOPLATIN

Search structure
Trade Names:
Synonyms:
Status: Approved (1989)
Entry Type: Small molecule
Molecule Category: Parent
ATC: L01XA02
UNII: BG3F62OND5

Physicochemical Descriptors

Property Name Value
Molecular Formula C6H12N2O4Pt
Molecular Weight 371.25
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Experimental and Estimated Properties

Property Name Value Unit Method
log P (octanol-water) -0.460 - EST
Atmospheric OH Rate Constant 1.19E-12 cm3/molecule-sec EST

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA inhibitor FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 103

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Ovarian Neoplasms 4 D010051 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Ovarian Neoplasms 4 D010051 ClinicalTrials
Ovarian Neoplasms 4 D010051 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Retinoblastoma 3 D012175 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Hodgkin Disease 3 D006689 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Ependymoma 3 D004806 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Glioblastoma 3 D005909 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Nasopharyngeal Neoplasms 3 D009303 ClinicalTrials
Testicular Neoplasms 3 D013736 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Testicular Neoplasms 3 D013736 ClinicalTrials
Neuroectodermal Tumors, Primitive 3 D018242 ClinicalTrials
Triple Negative Breast Neoplasms 3 D064726 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Lymphoma, Non-Hodgkin 3 D008228 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Inflammatory Breast Neoplasms 3 D058922 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Cholangiocarcinoma 3 D018281 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Gestational Trophoblastic Disease 3 D031901 ClinicalTrials
Carcinoma, Endometrioid 3 D018269 ClinicalTrials
Adenocarcinoma of Lung 3 D000077192 ClinicalTrials
Carcinoma 3 D002277 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Retroviridae Infections 3 D012192 ClinicalTrials
Oropharyngeal Neoplasms 3 D009959 ClinicalTrials
Astrocytoma 3 D001254 ClinicalTrials
Ganglioneuroblastoma 3 D018305 ClinicalTrials
Peripheral Nervous System Diseases 3 D010523 ClinicalTrials
Pain 3 D010146 ClinicalTrials
Peripheral Nervous System Diseases 3 D010523 ClinicalTrials
Central Nervous System Neoplasms 3 D016543 ClinicalTrials
Hepatoblastoma 3 D018197 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Brain Neoplasms 3 D001932 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Thyroid Neoplasms 3 D013964 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Laryngeal Neoplasms 3 D007822 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Liver Neoplasms 3 D008113 ClinicalTrials
Uterine Neoplasms 3 D014594 ClinicalTrials
Skin Neoplasms 3 D012878 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Seminoma 3 D018239 ClinicalTrials
Ependymoma 3 D004806 ClinicalTrials
Testicular Neoplasms 3 D013736 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 3 D009373 ClinicalTrials
Urethral Neoplasms 3 D014523 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Hodgkin Disease 3 D006689 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Ependymoma 3 D004806 ClinicalTrials
Choroid Plexus Neoplasms 3 D016545 ClinicalTrials
Leukemia-Lymphoma, Adult T-Cell 3 D015459 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Oropharyngeal Neoplasms 3 D009959 ClinicalTrials
Sex Cord-Gonadal Stromal Tumors 3 D018312 ClinicalTrials
Oropharyngeal Neoplasms 3 D009959 ClinicalTrials
Mouth Neoplasms 3 D009062 ClinicalTrials
Anemia 3 D000740 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Laryngeal Neoplasms 3 D007822 ClinicalTrials
Carcinoma 3 D002277 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 3 D009373 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Neuroblastoma 3 D009447 ClinicalTrials
Thyroid Neoplasms 3 D013964 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Small Cell Lung Carcinoma 3 D055752 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Astrocytoma 3 D001254 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Medulloblastoma 3 D008527 ClinicalTrials
Carcinoma, Large Cell 3 D018287 ClinicalTrials
Brain Neoplasms 3 D001932 ClinicalTrials
Uterine Neoplasms 3 D014594 ClinicalTrials
Urogenital Neoplasms 3 D014565 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Carcinosarcoma 2 D002296 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Myeloproliferative Disorders 2 D009196 ClinicalTrials
Wilms Tumor 2 D009396 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Carcinoma, Islet Cell 2 D018273 ClinicalTrials
Cystadenoma, Serous 2 D018293 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Thrombosis 2 D013927 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 D054198 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Breast Neoplasms, Male 2 D018567 ClinicalTrials
Gliosarcoma 2 D018316 ClinicalTrials
Carcinoma, Merkel Cell 2 D015266 ClinicalTrials
Brain Stem Neoplasms 2 D020295 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Adenocarcinoma, Bronchiolo-Alveolar 2 D002282 ClinicalTrials
Burkitt Lymphoma 2 D002051 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Hereditary Breast and Ovarian Cancer Syndrome 2 D061325 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Carcinoma, Intraductal, Noninfiltrating 2 D002285 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Leiomyosarcoma 2 D007890 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Ureteral Neoplasms 2 D014516 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Adenocarcinoma 1 D000230 ClinicalTrials
HIV Infections 1 D015658 ClinicalTrials
Carcinoma, Renal Cell 1 D002292 ClinicalTrials
Multiple Myeloma 1 D009101 ClinicalTrials
Adrenal Cortex Neoplasms 1 D000306 ClinicalTrials
Vulvar Neoplasms 1 D014846 ClinicalTrials
Gallbladder Neoplasms 1 D005706 ClinicalTrials
Adenocarcinoma, Follicular 1 D018263 ClinicalTrials
Anus Neoplasms 1 D001005 ClinicalTrials
Insulinoma 1 D007340 ClinicalTrials
Pancreatic Neoplasms 1 D010190 ClinicalTrials
Skin Diseases 1 D012871 ClinicalTrials
Somatostatinoma 1 D013005 ClinicalTrials
Lymphoma, Large-Cell, Anaplastic 1 D017728 ClinicalTrials
Genital Neoplasms, Female 1 D005833 ClinicalTrials
Hypopharyngeal Neoplasms 1 D007012 ClinicalTrials
Appendiceal Neoplasms 1 D001063 ClinicalTrials
Parathyroid Neoplasms 1 D010282 ClinicalTrials
Pericardial Effusion 1 D010490 ClinicalTrials
Pleural Effusion 1 D010996 ClinicalTrials
Vaginal Neoplasms 1 D014625 ClinicalTrials
Lymphoma, Mantle-Cell 1 D020522 ClinicalTrials
Carcinoma, Verrucous 1 D018289 ClinicalTrials

Side Effects from Label

Side effects Relative Frequency (%) Labels
Gastrointestinal disorders Nausea 92.0
Gastrointestinal disorders Vomiting 92.0
Blood and lymphatic system disorders Anaemia 90.0
Blood and lymphatic system disorders Leukopenia 85.0
Gastrointestinal disorders Vomiting 81.0
Blood and lymphatic system disorders Anaemia 71.0
Blood and lymphatic system disorders Neutropenia 67.0
Gastrointestinal disorders Vomiting 64.0
Blood and lymphatic system disorders Thrombocytopenia 62.0
Gastrointestinal disorders Vomiting 53.0
Metabolism and nutrition disorders Hypomagnesaemia 29.0
Metabolism and nutrition disorders Hyponatraemia 29.0
Investigations Blood alkaline phosphatase increased 24.0
General disorders and administration site conditions Pain 23.0
Metabolism and nutrition disorders Hypocalcaemia 22.0
Metabolism and nutrition disorders Hypokalaemia 20.0
Gastrointestinal disorders Abdominal pain 17.0
Gastrointestinal disorders Gastrointestinal pain 17.0
Investigations Aspartate aminotransferase increased 15.0
Gastrointestinal disorders Nausea 15.0
Investigations Blood urea increased 14.0
General disorders and administration site conditions Asthenia 11.0
General disorders and administration site conditions Asthenia 8.0
Investigations Blood creatinine increased 6.0
Gastrointestinal disorders Constipation 6.0
Gastrointestinal disorders Diarrhoea 6.0
Nervous system disorders Neuropathy peripheral 6.0
Investigations Blood bilirubin increased 5.0
Investigations Haemoglobin 5.0
Vascular disorders Haemorrhage 5.0
Infections and infestations Infection 5.0
Injury, poisoning and procedural complications Neurotoxicity 5.0
Infections and infestations Infection 4.0
Nervous system disorders Neuropathy peripheral 4.0
Skin and subcutaneous tissue disorders Alopecia 3.0
Gastrointestinal disorders Constipation 3.0
Skin and subcutaneous tissue disorders Alopecia 2.0
Gastrointestinal disorders Dysgeusia 1.0
General disorders and administration site conditions Influenza like illness 1.0
General disorders and administration site conditions Mucosal inflammation 1.0
Ear and labyrinth disorders Ototoxicity 1.0
Ear and labyrinth disorders Tinnitus 1.0

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
13.33
Blood and lymphatic system disorders
9.84
Gastrointestinal disorders
8.85
Respiratory, thoracic and mediastinal disorders
7.71
Vascular disorders
7.18
Nervous system disorders
6.78
Skin and subcutaneous tissue disorders
5.58
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
5.23
Infections and infestations
4.88
Cardiac disorders
4.69
Injury, poisoning and procedural complications
4.08
Investigations
3.52
Metabolism and nutrition disorders
3.4
Renal and urinary disorders
2.77
Immune system disorders
2.77
Musculoskeletal and connective tissue disorders
2.35

Cross References

Resources Reference
CAS NUMBER 41575-94-4
ChEBI 35694
ChEMBL CHEMBL1351
DrugBank DB00958
FDA SRS BG3F62OND5
Guide to Pharmacology 7624
PubChem 10339178
ZINC ZINC00404340
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