CEFUROXIME AXETIL

Search structure
Trade Names:
Synonyms:
Status: Approved (1987)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
UNII: Z49QDT0J8Z

Structure
InChI Key KEJCWVGMRLCZQQ-YJBYXUATSA-N
Smile CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)OC(C)OC(C)=O)=C(COC(N)=O)CS[C@H]12)c1ccco1
InChI
InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H22N4O10S
Molecular Weight 510.48
AlogP -0.17
Hydrogen Bond Acceptor 12.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 9.0
Polar Surface Area 189.06
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 35.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Bacterial penicillin-binding protein inhibitor KEGG PubMed DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Primary active transporter ATP-binding cassette ABCC subfamily
- 28000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Osteomyelitis 0 D010019 ClinicalTrials

Related Entries

MCS

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Skin and subcutaneous tissue disorders
10.87
Immune system disorders
10.39
General disorders and administration site conditions
10.11
Gastrointestinal disorders
8.36
Vascular disorders
8.15
Respiratory, thoracic and mediastinal disorders
6.89
Injury, poisoning and procedural complications
6.54
Nervous system disorders
5.97
Cardiac disorders
5.79
Eye disorders
4.67
Infections and infestations
4.28
Investigations
3.01
Psychiatric disorders
2.54
Musculoskeletal and connective tissue disorders
2.02

Cross References

Resources Reference
ChEBI 3516
ChEMBL CHEMBL1095930
DrugCentral 566
FDA SRS Z49QDT0J8Z
KEGG C08107
PubChem 6321416
SureChEMBL SCHEMBL721709
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