CHLOROTHIAZIDE SODIUM

Search structure
Trade Names:
Synonyms:
Status: Approved (1958)
Entry Type: Small molecule
Molecule Category: Salt
UNII: SN86FG7N2K
Parent Compound: CHLOROTHIAZIDE

Structure
InChI Key CPIWHAFLBZQYLQ-UHFFFAOYSA-N
Smile NS(=O)(=O)c1cc2c(cc1Cl)N=C[N-]S2(=O)=O.[Na+]
InChI
InChI=1S/C7H5ClN3O4S2.Na/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5;/h1-3H,(H2-,9,10,11,12,13);/q-1;+1

Physicochemical Descriptors

Property Name Value
Molecular Formula C7H5ClN3NaO4S2
Molecular Weight 317.71
AlogP -0.06
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 118.69
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 17.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Thiazide-sensitive sodium-chloride cotransporter inhibitor DOI

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
23.08
Metabolism and nutrition disorders
23.08
Injury, poisoning and procedural complications
15.38
Respiratory, thoracic and mediastinal disorders
15.38
Vascular disorders
15.38
Renal and urinary disorders
7.69

Cross References

Resources Reference
ChEMBL CHEMBL1200616
EPA CompTox DTXSID00221091
FDA SRS SN86FG7N2K
PubChem 23675744
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