| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1977) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| ATC: | A02BA01 |
| UNII: | 80061L1WGD |
Structure
| InChI Key | AQIXAKUUQRKLND-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C10H16N6S |
| Molecular Weight | 252.35 |
| AlogP | 0.6 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 5.0 |
| Polar Surface Area | 88.89 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 17.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Histamine H2 receptor antagonist | ISBN |
| Primary Target | |
|---|---|
| H2 receptor |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Gastrointestinal Hemorrhage | 3 | D006471 | ClinicalTrials |
| Dermatitis, Atopic | 3 | D003876 | ClinicalTrials |
| Ulcer | 3 | D014456 | ClinicalTrials |
| Hemorrhage | 3 | D006470 | ClinicalTrials |
| Breast Carcinoma In Situ | 2 | D000071960 | ClinicalTrials |
| Endometrial Neoplasms | 2 | D016889 | ClinicalTrials |
| Amyotrophic Lateral Sclerosis | 1 | D000690 | ClinicalTrials |
| Pulmonary Disease, Chronic Obstructive | 1 | D029424 | ClinicalTrials |
| Anxiety Disorders | 1 | D001008 | ClinicalTrials |
Related Entries
Side Effects from Label
Side Effects (PT)
| Side effects | Relative Frequency (%) | Labels | |
|---|---|---|---|
| Nervous system disorders Headache | 3.1 | ||
| Gastrointestinal disorders Diarrhoea | 1.8 | ||
| General disorders and administration site conditions Asthenia | 1.7 | ||
| General disorders and administration site conditions Fatigue | 1.7 | ||
| Cardiac disorders Dizziness | 1.3 | ||
| Nervous system disorders Somnolence | 1.3 | ||
| Skin and subcutaneous tissue disorders Dermatitis | 1.2 | ||
| Skin and subcutaneous tissue disorders Rash | 1.2 | ||
| Gastrointestinal disorders Constipation | 1.0 |
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 51481-61-9 |
| ChEBI | 3699 |
| ChEMBL | CHEMBL30 |
| DrugBank | DB00501 |
| DrugCentral | 645 |
| EPA CompTox | DTXSID4020329 |
| FDA SRS | 80061L1WGD |
| Human Metabolome Database | HMDB0014644 |
| Guide to Pharmacology | 1231 |
| KEGG | C06952 |
| PharmGKB | PA449001 |
| PubChem | 2756 |
| SureChEMBL | SCHEMBL1093 |
| ZINC | ZINC000018115268 |
CONTENTS