CISPLATIN

Search structure
Trade Names:
Synonyms:
Status: Approved (1978)
Entry Type: Small molecule
Molecule Category: Parent
ATC: L01XA01
UNII: Q20Q21Q62J

Physicochemical Descriptors

Property Name Value
Molecular Formula H6Cl2N2Pt+2
Molecular Weight 300.05
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 5 Cytochrome P450 family 5A Cytochrome P450 5A1
- 9347 - - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase MAPK family CMGC protein kinase ERK subfamily
- 4624 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family
- 2621 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family
- 22949 - - -
Enzyme Transferase
- 3820 - - 98.71
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -18.03-5.52
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CC chemokine receptor
- 18142 - 7012 -
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CXC chemokine receptor
- 13516 - 9461 -
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Melanocortin receptor
- 6434 - 6035 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Nucleotide-like receptor (family A GPCR) Adenosine receptor
- 4243 - 2398 -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group A Nuclear hormone receptor subfamily 3 group A member 1
- 2500-10300 - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group A Nuclear hormone receptor subfamily 3 group A member 2
- 2500-10300 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 108.66
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- - - 925000 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Nasopharyngeal Neoplasms 3 D009303 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Osteosarcoma 3 D012516 ClinicalTrials
Small Cell Lung Carcinoma 3 D055752 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Lymphoma, Mantle-Cell 3 D020522 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Hodgkin Disease 3 D006689 ClinicalTrials
Lymphoma, T-Cell, Peripheral 3 D016411 ClinicalTrials
Adenocarcinoma 3 D000230 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 3 D009373 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Carcinoma 3 D002277 ClinicalTrials
Anus Neoplasms 3 D001005 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Laryngeal Neoplasms 3 D007822 ClinicalTrials
Teratoma 3 D013724 ClinicalTrials
Liver Neoplasms 3 D008113 ClinicalTrials
Uterine Neoplasms 3 D014594 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Seminoma 3 D018239 ClinicalTrials
Biliary Tract Neoplasms 3 D001661 ClinicalTrials
Ependymoma 3 D004806 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 3 D009373 ClinicalTrials
Urethral Neoplasms 3 D014523 ClinicalTrials
Gallbladder Neoplasms 3 D005706 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Hodgkin Disease 3 D006689 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Ependymoma 3 D004806 ClinicalTrials
Choroid Plexus Neoplasms 3 D016545 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Oropharyngeal Neoplasms 3 D009959 ClinicalTrials
Sex Cord-Gonadal Stromal Tumors 3 D018312 ClinicalTrials
Oropharyngeal Neoplasms 3 D009959 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 3 D000077195 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Paranasal Sinus Neoplasms 3 D010255 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Mouth Neoplasms 3 D009062 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 3 D000077195 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 3 D000077195 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 3 D000077195 ClinicalTrials
Skin Neoplasms 3 D012878 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Retinoblastoma 3 D012175 ClinicalTrials
Gestational Trophoblastic Disease 3 D031901 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Ependymoma 3 D004806 ClinicalTrials
Adenocarcinoma 3 D000230 ClinicalTrials
Testicular Neoplasms 3 D013736 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Nasopharyngeal Carcinoma 3 D000077274 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Neuroblastoma 3 D009447 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Malaria 3 D008288 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Multiple Myeloma 3 D009101 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Thymus Neoplasms 3 D013953 ClinicalTrials
Medulloblastoma 3 D008527 ClinicalTrials
Laryngeal Neoplasms 3 D007822 ClinicalTrials
Uterine Neoplasms 3 D014594 ClinicalTrials
Urogenital Neoplasms 3 D014565 ClinicalTrials
Mouth Neoplasms 3 D009062 ClinicalTrials
Biliary Tract Neoplasms 3 D001661 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Testicular Neoplasms 3 D013736 ClinicalTrials
Gallbladder Neoplasms 3 D005706 ClinicalTrials
Testicular Neoplasms 3 D013736 ClinicalTrials
Cholangiocarcinoma 3 D018281 ClinicalTrials
Neuroectodermal Tumors, Primitive 3 D018242 ClinicalTrials
Triple Negative Breast Neoplasms 3 D064726 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Lymphoma, Non-Hodgkin 3 D008228 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Hepatoblastoma 3 D018197 ClinicalTrials
Inflammatory Breast Neoplasms 3 D058922 ClinicalTrials
Oropharyngeal Neoplasms 3 D009959 ClinicalTrials
Gallbladder Neoplasms 3 D005706 ClinicalTrials
Cholangiocarcinoma 3 D018281 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Adenocarcinoma of Lung 3 D000077192 ClinicalTrials
Brain Neoplasms 3 D001932 ClinicalTrials
Pharyngeal Neoplasms 3 D010610 ClinicalTrials
Carcinoma 3 D002277 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Pleural Effusion 3 D010996 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Adrenal Cortex Neoplasms 3 D000306 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Stomatitis 3 D013280 ClinicalTrials
Postoperative Nausea and Vomiting 3 D020250 ClinicalTrials
Ganglioneuroblastoma 3 D018305 ClinicalTrials
Hypopharyngeal Neoplasms 3 D007012 ClinicalTrials
Anemia 3 D000740 ClinicalTrials
Mediastinal Neoplasms 3 D008479 ClinicalTrials
Stomatitis 3 D013280 ClinicalTrials
Central Nervous System Neoplasms 3 D016543 ClinicalTrials
Carcinoma, Embryonal 3 D018236 ClinicalTrials
Endodermal Sinus Tumor 3 D018240 ClinicalTrials
Choriocarcinoma 3 D002822 ClinicalTrials
Endodermal Sinus Tumor 3 D018240 ClinicalTrials
Mucositis 3 D052016 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Vulvar Neoplasms 3 D014846 ClinicalTrials
Brain Neoplasms 3 D001932 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Neoplasm Metastasis 2 D009362 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Carcinoma, Renal Cell 2 D002292 ClinicalTrials
Immunoblastic Lymphadenopathy 2 D007119 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Uveal Melanoma 2 D000098943 ClinicalTrials
Lymphoma, AIDS-Related 2 D016483 ClinicalTrials
Carcinoma, Merkel Cell 2 D015266 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Kidney Neoplasms 2 D007680 ClinicalTrials
Bile Duct Neoplasms 2 D001650 ClinicalTrials
Carcinoma, Pancreatic Ductal 2 D021441 ClinicalTrials
Carcinoma, Verrucous 2 D018289 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Lymphoma, Large-Cell, Anaplastic 2 D017728 ClinicalTrials
Tongue Neoplasms 2 D014062 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Carcinoma, Islet Cell 2 D018273 ClinicalTrials
Mesothelioma, Malignant 2 D000086002 ClinicalTrials
Digestive System Diseases 2 D004066 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Uveal Melanoma 2 D000098943 ClinicalTrials
Carcinoma, Large Cell 2 D018287 ClinicalTrials
Esthesioneuroblastoma, Olfactory 2 D018304 ClinicalTrials
Leukemia-Lymphoma, Adult T-Cell 2 D015459 ClinicalTrials
Penile Neoplasms 2 D010412 ClinicalTrials
Granuloma, Lethal Midline 2 D006103 ClinicalTrials
Nausea 2 D009325 ClinicalTrials
Paraganglioma 2 D010235 ClinicalTrials
Neoplasms, Cystic, Mucinous, and Serous 1 D018297 ClinicalTrials
Cystadenoma, Serous 1 D018293 ClinicalTrials
Digestive System Neoplasms 1 D004067 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials
Carcinoma, Endometrioid 1 D018269 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials
Xerostomia 1 D014987 ClinicalTrials
Neuroendocrine Tumors 1 D018358 ClinicalTrials
Primary Myelofibrosis 1 D055728 ClinicalTrials
Rhabdomyosarcoma 1 D012208 ClinicalTrials
Genital Neoplasms, Female 1 D005833 ClinicalTrials
Carcinoma, Basal Cell 1 D002280 ClinicalTrials
Klatskin Tumor 1 D018285 ClinicalTrials

Side Effects from Label

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Blood and lymphatic system disorders
10.78
Gastrointestinal disorders
10.42
General disorders and administration site conditions
9.77
Vascular disorders
9.44
Respiratory, thoracic and mediastinal disorders
7.19
Nervous system disorders
6.59
Infections and infestations
5.69
Injury, poisoning and procedural complications
5.46
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
4.67
Metabolism and nutrition disorders
4.52
Cardiac disorders
4.25
Investigations
3.7
Skin and subcutaneous tissue disorders
3.21
Renal and urinary disorders
3.2

Cross References

Resources Reference
CAS NUMBER 15663-27-1
ChEMBL CHEMBL11359
DrugBank DB00515
FDA SRS Q20Q21Q62J
Guide to Pharmacology 5343
PDB NCP
PubChem 23644016
SureChEMBL SCHEMBL5838
CAS NUMBER 15663-27-1
ChEMBL CHEMBL2068237
DrugBank DB00515
FDA SRS Q20Q21Q62J
Guide to Pharmacology 5343
PDB NCP
PubChem 23644016
SureChEMBL SCHEMBL5838
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