CRISABOROLE

Search structure
Trade Names:
Synonyms:
Status: Approved (2016)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: D11AH06
UNII: Q2R47HGR7P

Structure
InChI Key USZAGAREISWJDP-UHFFFAOYSA-N
Smile N#Cc1ccc(Oc2ccc3c(c2)COB3O)cc1
InChI
InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H10BNO3
Molecular Weight 251.05
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Phosphodiesterase 4 inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 670 - - -
Enzyme Phosphodiesterase Phosphodiesterase 1 Phosphodiesterase 1A
- 6100-5600000 - - -
Enzyme Phosphodiesterase Phosphodiesterase 1 Phosphodiesterase 1B
- 17900000 - - -
Enzyme Phosphodiesterase Phosphodiesterase 1 Phosphodiesterase 1C
- 71000000 - - -
Enzyme Phosphodiesterase Phosphodiesterase 10 Phosphodiesterase 10A
- 97600000 - - -
Enzyme Phosphodiesterase Phosphodiesterase 2 Phosphodiesterase 2A
- 3630000 - - -
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3A
- 64000000 - - -
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3B
- 58800000 - - -
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4A
- 110-490 - - -
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4B
- 55-70000 - - 11
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4C
- 110-490 - - -
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4D
- 55-1140 - - -
Enzyme Phosphodiesterase Phosphodiesterase 5 Phosphodiesterase 5A
- 56100000 - - -
Enzyme Phosphodiesterase Phosphodiesterase 7 Phosphodiesterase 7A
- 730-2030000 - - -
Enzyme Transferase
- - - - -0.9307-7.43
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -6.37--1.37

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Scleroderma, Localized 2 D012594 ClinicalTrials
Vitiligo 2 D014820 ClinicalTrials
Alopecia Areata 2 D000506 ClinicalTrials
Dermatitis 2 D003872 ClinicalTrials
Psoriasis 2 D011565 ClinicalTrials

Related Entries

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
39.22
Injury, poisoning and procedural complications
22.38
Skin and subcutaneous tissue disorders
19.97
Nervous system disorders
8.32
Immune system disorders
4.47

Cross References

Resources Reference
CAS NUMBER 906673-24-3
ChEBI 134677
ChEMBL CHEMBL484785
DrugBank DB05219
DrugCentral 5201
EPA CompTox DTXSID10238231
FDA SRS Q2R47HGR7P
Guide to Pharmacology 9151
PubChem 44591583
SureChEMBL SCHEMBL595261
ZINC ZINC000169748244
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