CROTAMITON

Search structure


Trade Names:	CROTAN EURAX
Synonyms:	Crotamiton Crotan Eurax N-ethylcrotono-o-toluidide N-ethyl-o-crotonotoluidide NSC-758951
Status:	Approved (1949)
Entry Type:	Small molecule
Molecule Category:	Parent
UNII:	2EEH27851Y

Structure


InChI Key	DNTGGZPQPQTDQF-XBXARRHUSA-N
Smile	C/C=C/C(=O)N(CC)c1ccccc1C
InChI	InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C13H17NO
Molecular Weight	203.28
AlogP	2.92
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	0.0
Number of Rotational Bond	3.0
Polar Surface Area	20.31
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	15.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	72

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
Injury, poisoning and procedural complications	27.27
Skin and subcutaneous tissue disorders	27.27
Congenital, familial and genetic disorders	18.18
General disorders and administration site conditions	18.18
Immune system disorders	9.09

Cross References

Resources	Reference
CAS NUMBER	483-63-6
ChEMBL	CHEMBL1200709
FDA SRS	2EEH27851Y
Guide to Pharmacology	11165
PharmGKB	PA164745460
SureChEMBL	SCHEMBL32934
ZINC	ZINC000000056427

CONTENTS