| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1961) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt |
| UNII: | NJ82J0F8QC |
| Parent Compound: | CYPROHEPTADINE |
Structure
| InChI Key | ZPMVNZLARAEGHB-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C21H22ClN |
| Molecular Weight | 323.87 |
| AlogP | 4.7 |
| Hydrogen Bond Acceptor | 1.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 0.0 |
| Polar Surface Area | 3.24 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 22.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Histamine H1 receptor antagonist |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Transferase
|
- | - | - | - | 5.772 | |
|
Epigenetic regulator
Eraser
Histone deacetylase
HDAC class IIb
|
- | - | - | - | -3.5-9.88 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Neoplasms | 3 | D009369 | ClinicalTrials |
Related Entries
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 59695 |
| ChEMBL | CHEMBL1716 |
| EPA CompTox | DTXSID5042586 |
| FDA SRS | NJ82J0F8QC |
| Guide to Pharmacology | 277 |
| KEGG | C06935 |
| PubChem | 43834424 |
| SureChEMBL | SCHEMBL41842 |
| ZINC | ZINC00968264 |
CONTENTS