DrugMapper


Trade Names:	CYTARABINE CYTOSAR-U DEPOCYT
Synonyms:	Alexan Alexan 100 Arabinocytosine Arabinosyl cytosine Ara-c Ara-cytidine Aracytidine Aracytin Aracytine Cytarabine Cytarabine liposome Cytarabinoside Cytarabinum Cytosar Cytosar-u Depocyt Depocyte NSC-287459 Spongocytidine Tarabine Pfs U-19,920 U-19920 U 19920a
Status:	Approved (1969)
Entry Type:	Small molecule
Molecule Category:	Parent
ATC:	L01BC01
UNII:	04079A1RDZ


InChI Key	UHDGCWIWMRVCDJ-CCXZUQQUSA-N
Smile	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1
InChI	InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1

Property Name	Value
Molecular Formula	C9H13N3O5
Molecular Weight	243.22
AlogP	-2.56
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	4.0
Number of Rotational Bond	2.0
Polar Surface Area	130.83
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	17.0

Property Name	Value	Unit	Method
log P (octanol-water)	-2.460	-	EST
Atmospheric OH Rate Constant	1.23E-10	cm3/molecule-sec	EST
Melting Point	212.5	deg C	EXP

Action	Mechanism of Action	Reference
INHIBITOR	DNA inhibitor	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	59000	-	-	-
Other nuclear protein	-	20	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	79

Mesh Heading	Maximum Phase	Mesh ID	Reference
Precursor Cell Lymphoblastic Leukemia-Lymphoma	4	D054198	ClinicalTrials
Leukemia, Myeloid, Acute	4	D015470	ClinicalTrials
Leukemia, Myeloid, Acute	4	D015470	ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma	4	D054198	ClinicalTrials
Leukemia, Myeloid, Acute	4	D015470	ClinicalTrials
Neoplasms	4	D009369	ClinicalTrials
Leukemia, Monocytic, Acute	3	D007948	ClinicalTrials
Leukemia, Myelomonocytic, Acute	3	D015479	ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive	3	D015464	ClinicalTrials
Lymphoma, Large B-Cell, Diffuse	3	D016403	ClinicalTrials
Melanoma	3	D008545	ClinicalTrials
Malaria	3	D008288	ClinicalTrials
Multiple Myeloma	3	D009101	ClinicalTrials
Leukemia, Megakaryoblastic, Acute	3	D007947	ClinicalTrials
Leukemia, Basophilic, Acute	3	D015471	ClinicalTrials
Graft vs Host Disease	3	D006086	ClinicalTrials
Lymphoma	3	D008223	ClinicalTrials
Leukemia	3	D007938	ClinicalTrials
Leukemia, Promyelocytic, Acute	3	D015473	ClinicalTrials
Lymphoma, Mantle-Cell	3	D020522	ClinicalTrials
Leukemia, Biphenotypic, Acute	3	D015456	ClinicalTrials
Lymphoma, Follicular	3	D008224	ClinicalTrials
Hodgkin Disease	3	D006689	ClinicalTrials
Myelodysplastic Syndromes	3	D009190	ClinicalTrials
Leukemia, Biphenotypic, Acute	3	D015456	ClinicalTrials
Anemia, Refractory	3	D000753	ClinicalTrials
Myeloproliferative Disorders	3	D009196	ClinicalTrials
Lymphoma, Non-Hodgkin	3	D008228	ClinicalTrials
Sarcoma, Myeloid	3	D023981	ClinicalTrials
Histiocytosis, Langerhans-Cell	3	D006646	ClinicalTrials
Sarcoma, Myeloid	3	D023981	ClinicalTrials
Leukemia, Erythroblastic, Acute	3	D004915	ClinicalTrials
Renal Insufficiency, Chronic	3	D051436	ClinicalTrials
Leukemia, Myelomonocytic, Chronic	3	D015477	ClinicalTrials
Leukemia, Erythroblastic, Acute	3	D004915	ClinicalTrials
Myeloproliferative Disorders	3	D009196	ClinicalTrials
Anemia, Refractory, with Excess of Blasts	3	D000754	ClinicalTrials
Breast Neoplasms	3	D001943	ClinicalTrials
Hodgkin Disease	3	D006689	ClinicalTrials
Lymphoma, Follicular	3	D008224	ClinicalTrials
Leukemia, Biphenotypic, Acute	3	D015456	ClinicalTrials
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3	D054218	ClinicalTrials
Sarcoma	2	D012509	ClinicalTrials
Neutropenia	2	D009503	ClinicalTrials
Leukemia, Myelomonocytic, Juvenile	2	D054429	ClinicalTrials
Urinary Bladder, Overactive	2	D053201	ClinicalTrials
Ovarian Neoplasms	2	D010051	ClinicalTrials
Prostatic Neoplasms, Castration-Resistant	2	D064129	ClinicalTrials
Lymphoma, AIDS-Related	2	D016483	ClinicalTrials
Stiff-Person Syndrome	2	D016750	ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell	2	D015451	ClinicalTrials
Leukemia-Lymphoma, Adult T-Cell	2	D015459	ClinicalTrials
Lupus Erythematosus, Systemic	2	D008180	ClinicalTrials
Hematologic Neoplasms	2	D019337	ClinicalTrials
Neuromyelitis Optica	2	D009471	ClinicalTrials
Myasthenia Gravis	2	D009157	ClinicalTrials
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2	D020277	ClinicalTrials
Blast Crisis	2	D001752	ClinicalTrials
Central Nervous System Neoplasms	2	D016543	ClinicalTrials
Meningitis, Aseptic	2	D008582	ClinicalTrials
Lymphoma, Large-Cell, Anaplastic	2	D017728	ClinicalTrials
Opsoclonus-Myoclonus Syndrome	2	D053578	ClinicalTrials
Multiple Sclerosis, Relapsing-Remitting	2	D020529	ClinicalTrials
Burkitt Lymphoma	2	D002051	ClinicalTrials
Medulloblastoma	2	D008527	ClinicalTrials
Lymphoma, T-Cell, Peripheral	2	D016411	ClinicalTrials
Brain Neoplasms	1	D001932	ClinicalTrials
Glioblastoma	1	D005909	ClinicalTrials
Thrombocythemia, Essential	1	D013920	ClinicalTrials
Alopecia	1	D000505	ClinicalTrials
Polycythemia Vera	1	D011087	ClinicalTrials
Leukemia, Plasma Cell	1	D007952	ClinicalTrials
Primary Myelofibrosis	1	D055728	ClinicalTrials

	Relative Frequency (%)
Blood and lymphatic system disorders	14.0
Infections and infestations	12.61
General disorders and administration site conditions	11.88
Nervous system disorders	8.49
Respiratory, thoracic and mediastinal disorders	6.66
Gastrointestinal disorders	6.66
Vascular disorders	6.12
Injury, poisoning and procedural complications	4.18
Neoplasms benign, malignant and unspecified (incl cysts and polyps)	4.11
Investigations	3.9
Metabolism and nutrition disorders	3.46
Cardiac disorders	3.26
Skin and subcutaneous tissue disorders	2.98
Hepatobiliary disorders	2.33

Resources	Reference
CAS NUMBER	147-94-4
ChEBI	28680
ChEMBL	CHEMBL803
DrugBank	DB00987
DrugCentral	770
EPA CompTox	DTXSID3022877
FDA SRS	04079A1RDZ
Human Metabolome Database	HMDB0000089
Guide to Pharmacology	4827
KEGG	C02961
PDB	AR3
PharmGKB	PA449177
PubChem	6253
SureChEMBL	SCHEMBL3140
ZINC	ZINC000003795098

CYTARABINE

Structure

Physicochemical Descriptors

Experimental and Estimated Properties

Pharmacology

Indications

Related Entries

MCS

Scaffolds

Side Effects from Label

Adverse Reactions

Cross References

Side effects	Relative Frequency (%)	Labels
Eye disorders Conjunctivitis	80.0
Nervous system disorders Headache	56.4
Nervous system disorders Headache	56.0
General disorders and administration site conditions Asthenia	53.6
Gastrointestinal disorders Nausea	53.6
Nervous system disorders Headache	51.5
General disorders and administration site conditions Asthenia	46.4
General disorders and administration site conditions Fatigue	46.4
Investigations Body temperature increased	45.5
Gastrointestinal disorders Nausea	45.5
Gastrointestinal disorders Vomiting	43.6
Investigations Body temperature increased	42.9
Injury, poisoning and procedural complications Arachnoiditis	42.4
Nervous system disorders Headache	42.3
Injury, poisoning and procedural complications Arachnoiditis	42.0
General disorders and administration site conditions Asthenia	40.1
General disorders and administration site conditions Asthenia	39.4
Nervous system disorders Confusional state	36.4
General disorders and administration site conditions Feeling abnormal	36.4
Blood and lymphatic system disorders Neutropenia	36.4
Injury, poisoning and procedural complications Arachnoiditis	36.0
Nervous system disorders Confusional state	36.0
General disorders and administration site conditions Feeling abnormal	36.0
Injury, poisoning and procedural complications Arachnoiditis	35.7
Nervous system disorders Confusional state	33.5
General disorders and administration site conditions Feeling abnormal	33.5
Gastrointestinal disorders Nausea	33.3
Gastrointestinal disorders Vomiting	33.3
General disorders and administration site conditions Asthenia	33.0
Nervous system disorders Confusional state	33.0
General disorders and administration site conditions Feeling abnormal	33.0
Gastrointestinal disorders Diarrhoea	32.1
Nervous system disorders Headache	32.1
Blood and lymphatic system disorders Thrombocytopenia	32.1
Gastrointestinal disorders Vomiting	32.1
Investigations Body temperature increased	32.0
Investigations Body temperature increased	31.5
Gastrointestinal disorders Nausea	30.8
General disorders and administration site conditions Gait disturbance	29.0
General disorders and administration site conditions Gait disturbance	28.6
Musculoskeletal and connective tissue disorders Pain in extremity	28.6
Gastrointestinal disorders Vomiting	28.2
Nervous system disorders Headache	28.0
General disorders and administration site conditions Asthenia	27.3
Gastrointestinal disorders Diarrhoea	27.3
General disorders and administration site conditions Fatigue	27.3
Gastrointestinal disorders Constipation	25.0
Nervous system disorders Insomnia	25.0
Blood and lymphatic system disorders Neutropenia	25.0
Cardiac disorders Oedema peripheral	25.0
General disorders and administration site conditions Asthenia	24.9
Gastrointestinal disorders Constipation	24.9
General disorders and administration site conditions Fatigue	24.9
Gastrointestinal disorders Constipation	24.2
Blood and lymphatic system disorders Thrombocytopenia	24.2
Investigations Body temperature increased	24.0
Nervous system disorders Headache	24.0
Musculoskeletal and connective tissue disorders Back pain	23.7
General disorders and administration site conditions Gait disturbance	23.3
General disorders and administration site conditions Gait disturbance	23.0
Nervous system disorders Headache	23.0
Convulsion	22.0
Convulsion	21.8
Respiratory, thoracic and mediastinal disorders Cough	21.4
Cardiac disorders Dizziness	21.4
Cardiac disorders Dyspnoea	21.4
General disorders and administration site conditions Oedema	21.4
Musculoskeletal and connective tissue disorders Back pain	21.2
Convulsion	21.2
Cardiac disorders Dizziness	21.2
General disorders and administration site conditions Gait disturbance	21.2
Convulsion	21.0
Cardiac disorders Dizziness	21.0
General disorders and administration site conditions Gait disturbance	21.0
Convulsion	20.2
Convulsion	20.0
General disorders and administration site conditions Pain	20.0
Injury, poisoning and procedural complications Arachnoiditis	19.2
Musculoskeletal and connective tissue disorders Back pain	19.2
Investigations Body temperature increased	19.2
Injury, poisoning and procedural complications Arachnoiditis	19.0
General disorders and administration site conditions Asthenia	19.0
Cardiac disorders Dizziness	18.3
Blood and lymphatic system disorders Anaemia	18.2
Ear and labyrinth disorders Deafness	18.2
Metabolism and nutrition disorders Dehydration	18.2
Psychiatric disorders Depression	18.2
Hearing impaired	18.2
Vascular disorders Hypotension	18.2
Nervous system disorders Insomnia	18.2
Cardiac disorders Oedema peripheral	18.2
Infections and infestations Urinary tract infection	18.2
Cardiac disorders Dizziness	18.0
Gastrointestinal disorders Nausea	18.0
Nervous system disorders Tremor	18.0
Gastrointestinal disorders Vomiting	18.0
Blood and lymphatic system disorders Anaemia	17.9
Musculoskeletal and connective tissue disorders Back pain	17.9
General disorders and administration site conditions Decreased appetite	17.9
Gastrointestinal disorders Incontinence	17.9
General disorders and administration site conditions Pain	17.9
Cardiac disorders Tachycardia	17.9
Nervous system disorders Tremor	17.9
Infections and infestations Urinary tract infection	17.9
Gastrointestinal disorders Vomiting	17.0
Injury, poisoning and procedural complications Arachnoiditis	16.0
General disorders and administration site conditions Lethargy	16.0
Gastrointestinal disorders Nausea	16.0
Blood and lymphatic system disorders Thrombocytopenia	16.0
Gastrointestinal disorders Abdominal pain	15.2
Nervous system disorders Agitation	15.2
Gastrointestinal disorders Gastrointestinal pain	15.2
Vascular disorders Hypertension	15.2
Metabolism and nutrition disorders Hypokalaemia	15.2
Nervous system disorders Muscular weakness	15.2
Musculoskeletal and connective tissue disorders Neck pain	15.2
Musculoskeletal and connective tissue disorders Pain in extremity	15.2
Nervous system disorders Tremor	15.2
Nervous system disorders Tremor	15.0
Gastrointestinal disorders Abdominal pain	14.3
Musculoskeletal and connective tissue disorders Arthralgia	14.3
Psychiatric disorders Depression	14.3
Gastrointestinal disorders Gastrointestinal pain	14.3
General disorders and administration site conditions Lethargy	14.3
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	14.3
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness	14.3
Musculoskeletal and connective tissue disorders Nuchal rigidity	14.3
Skin and subcutaneous tissue disorders Pruritus	14.3
Eye disorders Vision blurred	14.3
Convulsion	14.1
Investigations Body temperature increased	14.0
Nervous system disorders Confusional state	14.0
Convulsion	14.0
General disorders and administration site conditions Feeling abnormal	14.0
Nervous system disorders Memory impairment	14.0
Musculoskeletal and connective tissue disorders Neck pain	14.0
Nervous system disorders Insomnia	13.6
General disorders and administration site conditions Pain	13.6
Infections and infestations Urinary tract infection	13.6
Blood and lymphatic system disorders Anaemia	13.0
General disorders and administration site conditions Asthenia	13.0
Gastrointestinal disorders Nausea	13.0
Metabolism and nutrition disorders Dehydration	12.8
Blood and lymphatic system disorders Anaemia	12.1
General disorders and administration site conditions Decreased appetite	12.1
Gastrointestinal disorders Diarrhoea	12.1
Cardiac disorders Dyspnoea	12.1
Endocrine disorders Hyperglycaemia	12.1
Nervous system disorders Hypoaesthesia	12.1
Metabolism and nutrition disorders Hyponatraemia	12.1
General disorders and administration site conditions Lethargy	12.1
Nervous system disorders Memory impairment	12.1
General disorders and administration site conditions Mucosal inflammation	12.1
Nervous system disorders Neuropathy peripheral	12.1
Musculoskeletal and connective tissue disorders Pain in extremity	12.1
Eye disorders Vision blurred	12.1
Investigations Body temperature increased	12.0
Nervous system disorders Hypoaesthesia	12.0
Nervous system disorders Memory impairment	12.0
Nervous system disorders Neuropathy peripheral	12.0
Nervous system disorders Somnolence	12.0
Gastrointestinal disorders Vomiting	12.0
Musculoskeletal and connective tissue disorders Arthralgia	11.3
General disorders and administration site conditions Decreased appetite	11.3
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	11.3
Eye disorders Vision blurred	11.3
Musculoskeletal and connective tissue disorders Back pain	11.0
Investigations Body temperature increased	11.0
Nervous system disorders Confusional state	11.0
Gastrointestinal disorders Constipation	11.0
Gastrointestinal disorders Diarrhoea	11.0
Cardiac disorders Dizziness	11.0
General disorders and administration site conditions Feeling abnormal	11.0
General disorders and administration site conditions Gait disturbance	11.0
Nervous system disorders Hypoaesthesia	11.0
Nervous system disorders Loss of consciousness	11.0
Gastrointestinal disorders Nausea	11.0
Nervous system disorders Neuropathy peripheral	11.0
Blood and lymphatic system disorders Neutropenia	11.0
Cardiac disorders Oedema peripheral	11.0
General disorders and administration site conditions Pain	11.0
Nervous system disorders Peripheral sensory neuropathy	11.0
Nervous system disorders Reflexes abnormal	11.0
Vascular disorders Shock	11.0
Nervous system disorders Somnolence	11.0
Cardiac disorders Syncope	11.0
Blood and lymphatic system disorders Thrombocytopenia	11.0
Nervous system disorders Urinary incontinence	11.0
Eye disorders Vision blurred	11.0
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness	10.9
Musculoskeletal and connective tissue disorders Nuchal rigidity	10.9
Psychiatric disorders Anxiety	10.7
Nervous system disorders Confusional state	10.7
Injury, poisoning and procedural complications Contusion	10.7
Ear and labyrinth disorders Deafness	10.7
General disorders and administration site conditions Decreased appetite	10.7
Metabolism and nutrition disorders Dehydration	10.7
Blood and lymphatic system disorders Diffuse large B-cell lymphoma	10.7
Cardiac disorders Dizziness	10.7
Gastrointestinal disorders Dysphagia	10.7
General disorders and administration site conditions Feeling abnormal	10.7
Gastrointestinal disorders Haemorrhoids	10.7
Hearing impaired	10.7
General disorders and administration site conditions Hyperhidrosis	10.7
Nervous system disorders Hypoaesthesia	10.7
Nervous system disorders Loss of consciousness	10.7
Musculoskeletal and connective tissue disorders Neck pain	10.7
Nervous system disorders Neuropathy peripheral	10.7
Nervous system disorders Peripheral sensory neuropathy	10.7
Investigations Platelet count decreased	10.7
Infections and infestations Pneumonia	10.7
Nervous system disorders Reflexes abnormal	10.7
Vascular disorders Shock	10.7
Cardiac disorders Syncope	10.7
Renal and urinary disorders Urinary retention	10.7
Cardiac disorders Oedema peripheral	10.5
Blood and lymphatic system disorders Thrombocytopenia	10.5
Nervous system disorders Agitation	10.1
Nervous system disorders Hypoaesthesia	10.1
Blood and lymphatic system disorders Neutropenia	10.1
Nervous system disorders Hypoaesthesia	10.0
Blood and lymphatic system disorders Thrombocytopenia	10.0
Cardiac disorders Dyspnoea	9.73
Nervous system disorders Muscular weakness	9.73
Musculoskeletal and connective tissue disorders Arthralgia	9.09
Respiratory, thoracic and mediastinal disorders Cough	9.09
Gastrointestinal disorders Dysphagia	9.09
Gastrointestinal disorders Incontinence	9.09
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	9.09
Nervous system disorders Neuropathy peripheral	9.09
General disorders and administration site conditions Pain	9.09
General disorders and administration site conditions Asthenia	9.0
Nervous system disorders Headache	9.0
Nervous system disorders Neuropathy peripheral	9.0
Blood and lymphatic system disorders Neutropenia	9.0
Nervous system disorders Tremor	9.0
Gastrointestinal disorders Abdominal pain	8.56
Gastrointestinal disorders Gastrointestinal pain	8.56
Cardiac disorders Tachycardia	8.56
Nervous system disorders Tremor	8.56
Psychiatric disorders Depression	8.17
Vascular disorders Hypotension	8.17
Blood and lymphatic system disorders Neutropenia	8.0
Blood and lymphatic system disorders Thrombocytopenia	8.0
Gastrointestinal disorders Dysphagia	7.78
Musculoskeletal and connective tissue disorders Neck pain	7.69
Gastrointestinal disorders Incontinence	7.39
Nervous system disorders Agitation	7.14
Endocrine disorders Hyperglycaemia	7.14
Metabolism and nutrition disorders Hypokalaemia	7.14
Vascular disorders Hypotension	7.14
General disorders and administration site conditions Mucosal inflammation	7.14
Nervous system disorders Muscular weakness	7.14
Musculoskeletal and connective tissue disorders Back pain	7.0
Nervous system disorders Confusional state	7.0
Gastrointestinal disorders Constipation	7.0
Convulsion	7.0
General disorders and administration site conditions Feeling abnormal	7.0
Metabolism and nutrition disorders Hyponatraemia	7.0
Cardiac disorders Oedema peripheral	7.0
Psychiatric disorders Anxiety	6.61
Respiratory, thoracic and mediastinal disorders Cough	6.61
Metabolism and nutrition disorders Hypokalaemia	6.61
Infections and infestations Pneumonia	6.23
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness	6.06
Musculoskeletal and connective tissue disorders Nuchal rigidity	6.06
Nervous system disorders Peripheral sensory neuropathy	6.06
Infections and infestations Pneumonia	6.06
General disorders and administration site conditions Asthenia	6.0
Convulsion	6.0
General disorders and administration site conditions Fatigue	6.0
Nervous system disorders Peripheral sensory neuropathy	6.0
Ear and labyrinth disorders Deafness	5.84
Hearing impaired	5.84
Endocrine disorders Hyperglycaemia	5.84
Vascular disorders Hypertension	5.84
General disorders and administration site conditions Decreased appetite	5.45
Renal and urinary disorders Urinary retention	5.45
General disorders and administration site conditions Asthenia	5.0
Nervous system disorders Headache	5.0
Blood and lymphatic system disorders Thrombocytopenia	5.0
Blood and lymphatic system disorders Anaemia	4.0
Investigations Body temperature increased	4.0
Nervous system disorders Confusional state	4.0
Convulsion	4.0
General disorders and administration site conditions Feeling abnormal	4.0
General disorders and administration site conditions Gait disturbance	4.0
Nervous system disorders Memory impairment	4.0
Gastrointestinal disorders Nausea	4.0
Musculoskeletal and connective tissue disorders Neck pain	4.0
Nervous system disorders Neuropathy peripheral	4.0
Nervous system disorders Somnolence	4.0
Convulsion	3.57
Vascular disorders Hypertension	3.57
Metabolism and nutrition disorders Hyponatraemia	3.57
Nervous system disorders Memory impairment	3.57
Nervous system disorders Neuropathy peripheral	3.57
Nervous system disorders Neuropathy peripheral	3.5
Cardiac disorders Dizziness	3.11
Gastrointestinal disorders Haemorrhoids	3.11
Nervous system disorders Loss of consciousness	3.11
General disorders and administration site conditions Mucosal inflammation	3.11
Investigations Platelet count decreased	3.11
Vascular disorders Shock	3.11
Cardiac disorders Syncope	3.11
Psychiatric disorders Anxiety	3.03
Injury, poisoning and procedural complications Contusion	3.03
General disorders and administration site conditions Decreased appetite	3.03
Blood and lymphatic system disorders Diffuse large B-cell lymphoma	3.03
General disorders and administration site conditions Hyperhidrosis	3.03
General disorders and administration site conditions Oedema	3.03
Nervous system disorders Cauda equina syndrome	3.0
Nervous system disorders Cranial nerve paralysis	3.0
Ear and labyrinth disorders Deafness	3.0
Cardiac disorders Dizziness	3.0
Nervous system disorders Hypoaesthesia	3.0
Nervous system disorders Loss of consciousness	3.0
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness	3.0
Nervous system disorders Neuropathy peripheral	3.0
Musculoskeletal and connective tissue disorders Nuchal rigidity	3.0
General disorders and administration site conditions Pain	3.0
Nervous system disorders Paraesthesia	3.0
Nervous system disorders Peripheral sensory neuropathy	3.0
Nervous system disorders Reflexes abnormal	3.0
Nervous system disorders Sensory loss	3.0
Vascular disorders Shock	3.0
Nervous system disorders Somnolence	3.0
Nervous system disorders Spinal cord disorder	3.0
Cardiac disorders Syncope	3.0
Nervous system disorders Urinary incontinence	3.0
Gastrointestinal disorders Vomiting	3.0
Nervous system disorders Neuropathy peripheral	2.72
Nervous system disorders Peripheral sensory neuropathy	2.72
Nervous system disorders Reflexes abnormal	2.72
Injury, poisoning and procedural complications Contusion	2.33
General disorders and administration site conditions Hyperhidrosis	2.33
General disorders and administration site conditions Oedema	2.33
Skin and subcutaneous tissue disorders Pruritus	2.33
Musculoskeletal and connective tissue disorders Back pain	2.0
Nervous system disorders Confusional state	2.0
General disorders and administration site conditions Feeling abnormal	2.0
General disorders and administration site conditions Gait disturbance	2.0
Nervous system disorders Headache	2.0
Nervous system disorders Hydrocephalus	2.0
Nervous system disorders Hypoaesthesia	2.0
Nervous system disorders Somnolence	2.0
Gastrointestinal disorders Vomiting	2.0
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness	1.28
Musculoskeletal and connective tissue disorders Nuchal rigidity	1.28
Nervous system disorders Altered state of consciousness	1.0
Blood and lymphatic system disorders Anaemia	1.0
Eye disorders Blindness	1.0
Cardiac disorders Cardio-respiratory arrest	1.0
Convulsion	1.0
General disorders and administration site conditions Gait disturbance	1.0
Nervous system disorders Hemiplegia	1.0
Nervous system disorders Meningism	1.0
General disorders and administration site conditions Pain	1.0
Blood and lymphatic system disorders Diffuse large B-cell lymphoma	0.389


Active Pharmaceutical Ingredients (APIs) Scaffolds	Exact Similarity SubStructure	Threshold (%) >= 70