DEFLAZACORT

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Trade Names:
Synonyms:
Status: Approved (2017)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
ATC: H02AB13
UNII: KR5YZ6AE4B

Structure
InChI Key FBHSPRKOSMHSIF-GRMWVWQJSA-N
Smile CC(=O)OCC(=O)[C@@]12N=C(C)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]12C
InChI
InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H31NO6
Molecular Weight 441.52
AlogP 2.56
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 102.26
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucocorticoid receptor agonist FDA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Muscular Dystrophies, Limb-Girdle 3 D049288 ClinicalTrials
Aspergillosis, Allergic Bronchopulmonary 2 D001229 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Related Entries

MCS

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Psychiatric disorders
13.27
General disorders and administration site conditions
11.55
Injury, poisoning and procedural complications
10.5
Gastrointestinal disorders
7.62
Investigations
7.42
Musculoskeletal and connective tissue disorders
7.16
Nervous system disorders
6.55
Skin and subcutaneous tissue disorders
6.19
Respiratory, thoracic and mediastinal disorders
6.09
Infections and infestations
5.84
Metabolism and nutrition disorders
4.64
Vascular disorders
2.79
Cardiac disorders
2.01

Cross References

Resources Reference
CAS NUMBER 14484-47-0
ChEBI 135720
ChEMBL CHEMBL1201891
DrugBank DB11921
DrugCentral 793
EPA CompTox DTXSID9020378
FDA SRS KR5YZ6AE4B
Guide to Pharmacology 9477
PubChem 189821
SureChEMBL SCHEMBL4018
ZINC ZINC000004212809
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