DENOSUMAB

Search structure
Trade Names:
Synonyms:
Status: Approved (2010)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: M05BX04
UNII: 4EQZ6YO2HI

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Tumor necrosis factor ligand superfamily member 11 inhibitor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Breast Neoplasms 4 D001943 ClinicalTrials
Breast Neoplasms 4 D001943 ClinicalTrials
Osteogenesis Imperfecta 3 D010013 ClinicalTrials
Arthritis, Rheumatoid 3 D001172 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Fractures, Bone 3 D050723 ClinicalTrials
Bone Diseases, Metabolic 3 D001851 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Diabetes Mellitus 3 D003920 ClinicalTrials
Carcinoma 3 D002277 ClinicalTrials
Anorexia Nervosa 3 D000856 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Inflammatory Breast Neoplasms 2 D058922 ClinicalTrials
Osteoarthritis, Hip 2 D015207 ClinicalTrials
Gout 2 D006073 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Osteolysis 2 D010014 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Histiocytosis, Langerhans-Cell 2 D006646 ClinicalTrials
Aortic Valve Stenosis 2 D001024 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Fibrous Dysplasia of Bone 2 D005357 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Hypersensitivity 2 D006967 ClinicalTrials
Infertility, Male 2 D007248 ClinicalTrials
Crohn Disease 1 D003424 ClinicalTrials
Ovarian Neoplasms 1 D010051 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Injury, poisoning and procedural complications
19.03
Musculoskeletal and connective tissue disorders
17.28
General disorders and administration site conditions
14.05
Gastrointestinal disorders
6.43
Vascular disorders
5.69
Nervous system disorders
5.34
Skin and subcutaneous tissue disorders
4.93
Infections and infestations
3.48
Respiratory, thoracic and mediastinal disorders
3.29
Investigations
2.95
Metabolism and nutrition disorders
2.38
Surgical and medical procedures
2.32
Cardiac disorders
2.13
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
2.02

Cross References

Resources Reference
CAS NUMBER 615258-40-7
ChEMBL CHEMBL1237023
FDA SRS 4EQZ6YO2HI
Guide to Pharmacology 6886
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