DESIPRAMINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
DMI
Status: Approved (1964)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 1Y58DO4MY1
Parent Compound: DESIPRAMINE

Structure
InChI Key XAEWZDYWZHIUCT-UHFFFAOYSA-N
Smile CNCCCN1c2ccccc2CCc2ccccc21.Cl
InChI
InChI=1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H23ClN2
Molecular Weight 302.85
AlogP 3.53
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 15.27
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 20.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Norepinephrine transporter inhibitor DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 3 - 1 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 56

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Back Pain 2 D001416 ClinicalTrials
Depressive Disorder 1 D003866 ClinicalTrials

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
15.89
General disorders and administration site conditions
14.99
Psychiatric disorders
14.64
Cardiac disorders
7.91
Gastrointestinal disorders
6.45
Injury, poisoning and procedural complications
6.38
Surgical and medical procedures
5.0
Vascular disorders
4.79
Investigations
4.44
Respiratory, thoracic and mediastinal disorders
3.82
Renal and urinary disorders
3.05
Immune system disorders
2.98
Metabolism and nutrition disorders
2.5
Skin and subcutaneous tissue disorders
2.43

Cross References

Resources Reference
ChEBI 4449
ChEMBL CHEMBL1696
EPA CompTox DTXSID9046942
FDA SRS 1Y58DO4MY1
Guide to Pharmacology 2399
KEGG C06943
PDB DSM
PubChem 65327
SureChEMBL SCHEMBL41992
ZINC ZINC01530611
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