DEXCHLORPHENIRAMINE MALEATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1981)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: B10YD955QW

Structure
InChI Key DBAKFASWICGISY-DASCVMRKSA-N
Smile CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
InChI
InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H23ClN2O4
Molecular Weight 390.87
AlogP 3.82
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 5.0
Polar Surface Area 16.13
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 19.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Histamine H1 receptor antagonist PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
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Metabolites

visNetwork

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Rhinitis, Allergic, Seasonal 4 D006255 ClinicalTrials
Multiple Sclerosis 3 D009103 ClinicalTrials
Sunburn 3 D013471 ClinicalTrials

Related Entries

MCS

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Pregnancy, puerperium and perinatal conditions
33.33
Injury, poisoning and procedural complications
16.67
Skin and subcutaneous tissue disorders
16.67
Surgical and medical procedures
16.67
Vascular disorders
16.67

Cross References

Resources Reference
ChEBI 4465
ChEMBL CHEMBL1200927
DrugBank DB09555
FDA SRS B10YD955QW
KEGG C07783
PubChem 5281070
SureChEMBL SCHEMBL119500
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