DIAZOXIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1973)
Entry Type: Small molecule
Molecule Category: Parent
ATC: C02DA01
UNII: O5CB12L4FN

Structure
InChI Key GDLBFKVLRPITMI-UHFFFAOYSA-N
Smile CC1=NS(=O)(=O)c2cc(Cl)ccc2N1
InChI
InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H7ClN2O2S
Molecular Weight 230.68
AlogP 1.87
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 0.0
Polar Surface Area 58.53
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 14.0

Pharmacology

Action Mechanism of Action Reference
OPENER Potassium channel, inwardly rectifying, subfamily J, member 11 opener ISBN DailyMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Inwardly rectifying potassium channel
8800-33000 - - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - - 13
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 92
Transporter Primary active transporter ATP-binding cassette ABCC subfamily
8800-33000 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Obesity 3 D009765 ClinicalTrials
Diabetes Mellitus, Type 2 2 D003924 ClinicalTrials
Depressive Disorder 1 D003866 ClinicalTrials

Related Entries

Salt

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Metabolism and nutrition disorders
14.6
General disorders and administration site conditions
10.17
Respiratory, thoracic and mediastinal disorders
7.82
Investigations
7.02
Gastrointestinal disorders
6.51
Infections and infestations
6.51
Cardiac disorders
6.39
Skin and subcutaneous tissue disorders
5.62
Nervous system disorders
5.01
Blood and lymphatic system disorders
4.43
Vascular disorders
4.14
Endocrine disorders
3.56
Renal and urinary disorders
3.51
Injury, poisoning and procedural complications
2.3

Cross References

Resources Reference
CAS NUMBER 364-98-7
ChEBI 4495
ChEMBL CHEMBL181
DrugBank DB01119
DrugCentral 854
EPA CompTox DTXSID7022914
FDA SRS O5CB12L4FN
Human Metabolome Database HMDB0015251
Guide to Pharmacology 2409
KEGG C06949
PDB 20J
PharmGKB PA449285
PubChem 3019
SureChEMBL SCHEMBL41254
ZINC ZINC000003872277
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