DIMETHYL SULFOXIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1978)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: G04BX13
UNII: YOW8V9698H

Structure
InChI Key IAZDPXIOMUYVGZ-UHFFFAOYSA-N
Smile C[S+](C)[O-]
InChI
InChI=1S/C2H6OS/c1-4(2)3/h1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C2H6OS
Molecular Weight 78.14
AlogP -0.01
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 0.0
Polar Surface Area 17.07
Molecular species None
Aromatic Rings 0.0
Heavy Atoms 4.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Protease Threonine protease Threonine protease PBT clan Threonine protease T1A subfamily
- - - - 5
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Opioid receptor
- - - - 4
Unclassified protein
- 20800 - 10700 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Urinary Bladder, Overactive 3 D053201 ClinicalTrials
Reflex, Abnormal 3 D012021 ClinicalTrials
Urinary Incontinence, Urge 3 D053202 ClinicalTrials
Cystitis, Interstitial 2 D018856 ClinicalTrials
Contracture 2 D003286 ClinicalTrials
Melanoma 1 D008545 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
HIV Infections 1 D015658 ClinicalTrials
Osteoarthritis 1 D010003 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
15.48
Cardiac disorders
13.1
Gastrointestinal disorders
13.1
Vascular disorders
13.1
General disorders and administration site conditions
9.52
Injury, poisoning and procedural complications
9.52
Renal and urinary disorders
7.14
Investigations
3.57
Skin and subcutaneous tissue disorders
3.57
Eye disorders
2.38
Psychiatric disorders
2.38
Respiratory, thoracic and mediastinal disorders
2.38

Cross References

Resources Reference
CAS NUMBER 67-68-5
ChEBI 28262
ChEMBL CHEMBL504
DrugBank DB01093
DrugCentral 906
EPA CompTox DTXSID2021735
FDA SRS YOW8V9698H
Human Metabolome Database HMDB0002151
KEGG C11143
PDB DMS
PharmGKB PA449342
PubChem 679
SureChEMBL SCHEMBL59
ZINC ZINC000005224188
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