DOPAMINE HYDROCHLORIDE

Search structure


Trade Names:	DOPAMINE HYDROCHLORIDE DOPAMINE HYDROCHLORIDE AND DEXTROSE 5% DOPAMINE HYDROCHLORIDE AND DEXTROSE 5% IN PLASTIC CONTAINER DOPAMINE HYDROCHLORIDE IN DEXTROSE 5% DOPAMINE HYDROCHLORIDE IN DEXTROSE 5% IN PLASTIC CONTAINER INTROPIN
Synonyms:	ASL-279 CARDIOSTERIL DOPAMINE HCL DOPAMINI HYDROCHLORIDUM DOPAMIN-NATTERMAN DOPMIN DYNATRA INOTROPIN INTROPIN NEOATRICON NSC-169105 SABAX DOPAMIN SELECTAJET TENSAMIN
Status:	Approved (1974)
Entry Type:	Small molecule
Molecule Category:	Salt
UNII:	7L3E358N9L
Parent Compound:	DOPAMINE

Structure


InChI Key	CTENFNNZBMHDDG-UHFFFAOYSA-N
Smile	Cl.NCCc1ccc(O)c(O)c1
InChI	InChI=1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C8H12ClNO2
Molecular Weight	189.64
AlogP	0.6
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	2.0
Polar Surface Area	66.48
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	11.0

Pharmacology

Action	Mechanism of Action	Reference
AGONIST	Beta-1 adrenergic receptor agonist

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	1979	-	-
Enzyme Transferase	-	-	-	-
Enzyme	-	1979	-	-
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb	-	-	-	-	-41.31--3.48
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	1144.73	-	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	0.631	1000-100000	-	2-11600	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	20000	-	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	66.46

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Parkinson Disease	3	D010300	ClinicalTrials

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
General disorders and administration site conditions	15.88
Vascular disorders	15.44
Cardiac disorders	14.88
Investigations	7.85
Immune system disorders	6.6
Injury, poisoning and procedural complications	6.04
Nervous system disorders	5.92
Respiratory, thoracic and mediastinal disorders	5.6
Skin and subcutaneous tissue disorders	4.48
Pregnancy, puerperium and perinatal conditions	2.74
Gastrointestinal disorders	2.3

Cross References

Resources	Reference
ChEBI	4698
ChEMBL	CHEMBL1557
EPA CompTox	DTXSID7020550
FDA SRS	7L3E358N9L
Guide to Pharmacology	940
KEGG	C03758
PDB	LDP
PubChem	46911794
SureChEMBL	SCHEMBL40951
ZINC	ZINC00033882

CONTENTS