| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1967) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 19XTS3T51U |
Structure
| InChI Key | JRNIHERUNQWMMW-WBYAVNBMSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C46H58Cl2N4O18 |
| Molecular Weight | 1025.89 |
| AlogP | -0.35 |
| Hydrogen Bond Acceptor | 9.0 |
| Hydrogen Bond Donor | 6.0 |
| Number of Rotational Bond | 2.0 |
| Polar Surface Area | 181.62 |
| Molecular species | ACID |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 32.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Bacterial 70S ribosome inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Transferase
|
- | - | - | - | 78.1 | |
|
Unclassified protein
|
- | - | - | - | 78.1 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Periodontitis | 3 | D010518 | ClinicalTrials |
| Chlamydia Infections | 3 | D002690 | ClinicalTrials |
| Rosacea | 3 | D012393 | ClinicalTrials |
| Macular Degeneration | 2 | D008268 | ClinicalTrials |
| Mucositis | 2 | D052016 | ClinicalTrials |
| Graves Ophthalmopathy | 2 | D049970 | ClinicalTrials |
| Telangiectasia, Hereditary Hemorrhagic | 2 | D013683 | ClinicalTrials |
| Tennis Elbow | 1 | D013716 | ClinicalTrials |
| Malaria | 1 | D008288 | ClinicalTrials |
Related Entries
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 34730 |
| ChEMBL | CHEMBL3989740 |
| EPA CompTox | DTXSID4041020 |
| FDA SRS | 19XTS3T51U |
| KEGG | C06973 |
| PDB | DXT |
| SureChEMBL | SCHEMBL40929 |
| ZINC | ZINC16052277 |
CONTENTS