| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1988) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | GV0O7ES0R3 |
Structure
| InChI Key | LZFZMUMEGBBDTC-QEJZJMRPSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C18H28N2O7 |
| Molecular Weight | 384.43 |
| AlogP | 1.13 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 8.0 |
| Polar Surface Area | 106.94 |
| Molecular species | ACID |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 25.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Angiotensin-converting enzyme inhibitor | FDA |
| Primary Target | |
|---|---|
| Angiotensin-converting enzyme |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Protease
Metallo protease
Metallo protease MAE clan
Metallo protease M2 family
|
- | 1-3100 | - | 1 | 74 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Cardiomyopathy, Dilated | 3 | D002311 | ClinicalTrials |
| Hypertension | 3 | D006973 | ClinicalTrials |
Related Entries
MCS
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 76420-72-9 |
| ChEBI | 59877 |
| ChEMBL | CHEMBL3989406 |
| FDA SRS | GV0O7ES0R3 |
| Guide to Pharmacology | 6332 |
| KEGG | C11720 |
| PDB | EAL |
| PubChem | 6917719 |
| SureChEMBL | SCHEMBL37288 |
| ZINC | ZINC03812851 |
| CAS NUMBER | 76420-72-9 |
| ChEBI | 4786 |
| ChEMBL | CHEMBL577 |
| DrugBank | DB09477 |
| DrugCentral | 1006 |
| EPA CompTox | DTXSID0048975 |
| FDA SRS | Q508Q118JM |
| Human Metabolome Database | HMDB0041886 |
| Guide to Pharmacology | 6332 |
| KEGG | C11720 |
| PDB | EAL |
| PubChem | 6917719 |
| SureChEMBL | SCHEMBL37289 |
| ZINC | ZINC000003812851 |
CONTENTS