ENOXACIN

Search structure
Trade Names:
Synonyms:
Status: Approved (1991)
Entry Type: Small molecule
Molecule Category: Parent
ATC: J01MA04
UNII: 325OGW249P

Structure
InChI Key IDYZIJYBMGIQMJ-UHFFFAOYSA-N
Smile CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21
InChI
InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H17FN4O3
Molecular Weight 320.32
AlogP 0.66
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 87.46
Molecular species ZWITTERION
Aromatic Rings 2.0
Heavy Atoms 23.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA gyrase inhibitor PubMed PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 10000 - - -
Enzyme Isomerase
- 14000 - - -
Other nuclear protein
- - 94 - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 111
Transporter Primary active transporter F-type and V-type ATPases V-type ATPase
- 10000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Amyotrophic Lateral Sclerosis 1 D000690 ClinicalTrials
Osteomyelitis 0 D010019 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 74011-58-8
ChEBI 157175
ChEMBL CHEMBL826
DrugBank DB00467
DrugCentral 1013
EPA CompTox DTXSID5022984
FDA SRS 325OGW249P
Human Metabolome Database HMDB0014610
Guide to Pharmacology 8882
KEGG C06979
PharmGKB PA449462
PubChem 3229
SureChEMBL SCHEMBL33963
ZINC ZINC000019594549
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