| Trade Names: | |
| Synonyms: | |
| Status: | Approved (2017) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| ATC: | A10BK04 |
| UNII: | 6C282481IP |
Structure
| InChI Key | MCIACXAZCBVDEE-CUUWFGFTSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H25ClO7 |
| Molecular Weight | 436.89 |
| AlogP | 1.36 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 4.0 |
| Number of Rotational Bond | 6.0 |
| Polar Surface Area | 108.61 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 30.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Sodium/glucose cotransporter 2 inhibitor | PubMed |
| Primary Target | |
|---|---|
| Sodium/glucose cotransporter 2 |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC05 family of sodium-dependent glucose transporters
|
- | 1-2 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Diabetes Mellitus, Type 2 | 4 | D003924 | FDA |
| Heart Failure | 2 | D006333 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1210344-57-2 |
| ChEMBL | CHEMBL1770248 |
| DrugBank | DB11827 |
| DrugCentral | 5270 |
| EPA CompTox | DTXSID40153120 |
| FDA SRS | 6C282481IP |
| Guide to Pharmacology | 8376 |
| PubChem | 44814423 |
| SureChEMBL | SCHEMBL181047 |
| ZINC | ZINC000068197809 |
CONTENTS