ESKETAMINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (2019)
Entry Type: Small molecule
Molecule Category: Salt
UNII: L8P1H35P2Z
Parent Compound: ESKETAMINE

Structure
InChI Key VCMGMSHEPQENPE-ZOWNYOTGSA-N
Smile CN[C@]1(c2ccccc2Cl)CCCCC1=O.Cl
InChI
InChI=1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H/t13-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H17Cl2NO
Molecular Weight 274.19
AlogP 2.9
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 29.1
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 16.0

Pharmacology

Action Mechanism of Action Reference
NEGATIVE ALLOSTERIC MODULATOR Glutamate [NMDA] receptor negative allosteric modulator PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Depressive Disorder, Major 4 D003865 FDA
Tinnitus 3 D014012 ClinicalTrials
Pain 1 D010146 ClinicalTrials

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
25.71
Psychiatric disorders
22.29
General disorders and administration site conditions
10.86
Gastrointestinal disorders
10.29
Injury, poisoning and procedural complications
6.29
Vascular disorders
5.14
Cardiac disorders
4.0
Investigations
2.86
Eye disorders
2.29
Respiratory, thoracic and mediastinal disorders
2.29

Cross References

Resources Reference
ChEBI 60800
ChEMBL CHEMBL2364609
FDA SRS L8P1H35P2Z
PubChem 44632368
SureChEMBL SCHEMBL15239422
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