ESTAZOLAM

Search structure
Trade Names:
Synonyms:
Status: Approved (1990)
Entry Type: Small molecule
Molecule Category: Parent
ATC: N05CD04
UNII: 36S3EQV54C

Structure
InChI Key CDCHDCWJMGXXRH-UHFFFAOYSA-N
Smile Clc1ccc2c(c1)C(c1ccccc1)=NCc1nncn1-2
InChI
InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H11ClN4
Molecular Weight 294.75
AlogP 3.27
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 1.0
Polar Surface Area 43.07
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
POSITIVE ALLOSTERIC MODULATOR GABA-A receptor; anion channel positive allosteric modulator ISBN PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

MCS

Scaffolds

Side Effects from Label

Side effects Relative Frequency (%) Labels
Nervous system disorders Somnolence 42.0
Nervous system disorders Headache
Nervous system disorders Somnolence
Nervous system disorders Headache 16.0
General disorders and administration site conditions Asthenia 11.0
Psychiatric disorders Nervousness
Psychiatric disorders Tension
General disorders and administration site conditions Asthenia
Nervous system disorders Hypokinesia 8.0
Psychiatric disorders Nervousness 8.0
Psychiatric disorders Tension 8.0
Cardiac disorders Dizziness 7.0
General disorders and administration site conditions Discomfort
General disorders and administration site conditions Discomfort 5.0
General disorders and administration site conditions Feeling abnormal
General disorders and administration site conditions Feeling abnormal 5.0
General disorders and administration site conditions Ill-defined disorder
General disorders and administration site conditions Ill-defined disorder 5.0
General disorders and administration site conditions Malaise
General disorders and administration site conditions Malaise 5.0
Infections and infestations Nasopharyngitis
Gastrointestinal disorders Nausea
Nervous system disorders Coordination abnormal 4.0
Nervous system disorders Hypokinesia
Gastrointestinal disorders Nausea 4.0
Psychiatric disorders Depression
Cardiac disorders Dizziness
General disorders and administration site conditions Hangover 3.0
Infections and infestations Nasopharyngitis 3.0
Musculoskeletal and connective tissue disorders Pain in extremity 3.0
Gastrointestinal disorders Abdominal pain
Musculoskeletal and connective tissue disorders Back pain
Musculoskeletal and connective tissue disorders Back pain 2.0
Nervous system disorders Confusional state 2.0
Psychiatric disorders Depression 2.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia 2.0
General disorders and administration site conditions Feeling abnormal 2.0
Gastrointestinal disorders Gastrointestinal pain
General disorders and administration site conditions Hangover
Social circumstances Mental disability 2.0
General disorders and administration site conditions Pain
General disorders and administration site conditions Pain 2.0
Musculoskeletal and connective tissue disorders Pain in extremity
Gastrointestinal disorders Pharyngitis
Nervous system disorders Thinking abnormal 2.0
Gastrointestinal disorders Abdominal pain 1.0
Cardiac disorders Chest pain
Cardiac disorders Chest pain 1.0
Nervous system disorders Coordination abnormal
Gastrointestinal disorders Gastrointestinal pain 1.0
Social circumstances Mental disability
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness 1.0
Gastrointestinal disorders Pharyngitis 1.0
Skin and subcutaneous tissue disorders Pruritus 1.0
Nervous system disorders Thinking abnormal

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
11.93
Psychiatric disorders
11.58
General disorders and administration site conditions
10.18
Respiratory, thoracic and mediastinal disorders
9.82
Injury, poisoning and procedural complications
8.07
Cardiac disorders
6.32
Infections and infestations
5.96
Musculoskeletal and connective tissue disorders
5.61
Metabolism and nutrition disorders
4.91
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
4.56
Endocrine disorders
3.51
Gastrointestinal disorders
3.16
Vascular disorders
3.16
Skin and subcutaneous tissue disorders
2.81
Renal and urinary disorders
2.46
Investigations
2.11

Cross References

Resources Reference
CAS NUMBER 29975-16-4
ChEBI 4858
ChEMBL CHEMBL285674
DrugBank DB01215
DrugCentral 1056
EPA CompTox DTXSID5020572
FDA SRS 36S3EQV54C
Human Metabolome Database HMDB0015346
Guide to Pharmacology 7550
KEGG C06981
PharmGKB PA449502
PubChem 3261
SureChEMBL SCHEMBL28766
ZINC ZINC000000001370
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