ETHIONAMIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1965)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
ATC: J04AD03
UNII: OAY8ORS3CQ

Structure
InChI Key AEOCXXJPGCBFJA-UHFFFAOYSA-N
Smile CCc1cc(C(N)=S)ccn1
InChI
InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H10N2S
Molecular Weight 166.25
AlogP 1.28
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 38.91
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 11.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Enoyl-[acyl-carrier-protein] reductase inhibitor PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Oxidoreductase
- 4000 - - 88-107
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 66

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Tuberculosis, Multidrug-Resistant 2 D018088 ClinicalTrials
Osteomyelitis 0 D010019 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Gastrointestinal disorders
21.74
Investigations
15.22
Blood and lymphatic system disorders
13.04
Nervous system disorders
10.87
Skin and subcutaneous tissue disorders
10.87
Cardiac disorders
6.52
General disorders and administration site conditions
6.52
Infections and infestations
4.35
Respiratory, thoracic and mediastinal disorders
4.35
Ear and labyrinth disorders
2.17
Musculoskeletal and connective tissue disorders
2.17
Vascular disorders
2.17

Cross References

Resources Reference
CAS NUMBER 536-33-4
ChEBI 4885
ChEMBL CHEMBL1441
DrugBank DB00609
DrugCentral 1083
EPA CompTox DTXSID0020577
FDA SRS OAY8ORS3CQ
Human Metabolome Database HMDB0014747
KEGG C07665
PharmGKB PA164768738
PubChem 2761171
SureChEMBL SCHEMBL27007
ZINC ZINC000003872520
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