| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1985) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt |
| UNII: | M8U465Q1WQ |
| Parent Compound: | FLECAINIDE |
Structure
| InChI Key | RKXNZRPQSOPPRN-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C19H24F6N2O5 |
| Molecular Weight | 474.4 |
| AlogP | 3.44 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 59.59 |
| Molecular species | BASE |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 28.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| BLOCKER | Sodium channel protein type V alpha subunit blocker |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Transferase
|
- | - | - | - | 14.83 | |
|
Epigenetic regulator
Eraser
Histone deacetylase
HDAC class IIb
|
- | - | - | - | -2.3--2.24 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Atrial Fibrillation | 3 | D001281 | ClinicalTrials |
| Pain | 2 | D010146 | ClinicalTrials |
Related Entries
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 5091 |
| ChEMBL | CHEMBL1200822 |
| EPA CompTox | DTXSID8020626 |
| FDA SRS | M8U465Q1WQ |
| Guide to Pharmacology | 2560 |
| KEGG | C07001 |
| PubChem | 41022 |
| SureChEMBL | SCHEMBL121583 |
| ZINC | ZINC03830842 |
CONTENTS