| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1990) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| ATC: | D01AC15 |
| UNII: | 8VZV102JFY |
Structure
| InChI Key | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C13H12F2N6O |
| Molecular Weight | 306.28 |
| AlogP | 0.74 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 5.0 |
| Polar Surface Area | 81.65 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 22.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Cytochrome P450 51 inhibitor | DailyMed |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Vaginal Discharge | 3 | D019522 | ClinicalTrials |
| Vaginosis, Bacterial | 3 | D016585 | ClinicalTrials |
| Neoplasms | 3 | D009369 | ClinicalTrials |
| Bacterial Infections | 3 | D001424 | ClinicalTrials |
| Infections | 3 | D007239 | ClinicalTrials |
| Mycoses | 3 | D009181 | ClinicalTrials |
| HIV Infections | 3 | D015658 | ClinicalTrials |
| Leukopenia | 3 | D007970 | ClinicalTrials |
| Neoplasms | 3 | D009369 | ClinicalTrials |
| Coccidioidomycosis | 3 | D003047 | ClinicalTrials |
| Candidemia | 3 | D058387 | ClinicalTrials |
| Aspergillosis | 3 | D001228 | ClinicalTrials |
| Candidiasis, Oral | 3 | D002180 | ClinicalTrials |
| Tinea Pedis | 3 | D014008 | ClinicalTrials |
| Leishmaniasis, Cutaneous | 3 | D016773 | ClinicalTrials |
| Candidiasis, Invasive | 3 | D058365 | ClinicalTrials |
| Histoplasmosis | 2 | D006660 | ClinicalTrials |
| Premature Birth | 2 | D047928 | ClinicalTrials |
| Crohn Disease | 2 | D003424 | ClinicalTrials |
| Blastomycosis | 2 | D001759 | ClinicalTrials |
| Sporotrichosis | 2 | D013174 | ClinicalTrials |
| Intracranial Hypertension | 2 | D019586 | ClinicalTrials |
| Vulvovaginitis | 2 | D014848 | ClinicalTrials |
| Respiratory Syncytial Virus Infections | 1 | D018357 | ClinicalTrials |
| Urinary Bladder, Overactive | 1 | D053201 | ClinicalTrials |
| Lymphoma | 1 | D008223 | ClinicalTrials |
| Non-alcoholic Fatty Liver Disease | 1 | D065626 | ClinicalTrials |
| Graft vs Host Disease | 1 | D006086 | ClinicalTrials |
| Pulmonary Disease, Chronic Obstructive | 1 | D029424 | ClinicalTrials |
| Alzheimer Disease | 1 | D000544 | ClinicalTrials |
| Leukemia, Myeloid, Acute | 1 | D015470 | ClinicalTrials |
| Vaginitis | 0 | D014627 | ClinicalTrials |
Related Entries
Scaffolds
Side Effects from Label
Side Effects (PT)
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 86386-73-4 |
| ChEBI | 46081 |
| ChEMBL | CHEMBL106 |
| DrugBank | DB00196 |
| DrugCentral | 1187 |
| EPA CompTox | DTXSID3020627 |
| FDA SRS | 8VZV102JFY |
| Human Metabolome Database | HMDB0014342 |
| KEGG | D00322 |
| PDB | TPF |
| PharmGKB | PA449653 |
| PubChem | 3365 |
| SureChEMBL | SCHEMBL3151 |
| ZINC | ZINC000000004009 |
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