FURAZOLIDONE

Search structure
Trade Names:
Synonyms:
Status: Approved (1958)
Entry Type: Small molecule
Molecule Category: Parent
ATC: G01AX06
UNII: 5J9CPU3RE0

Structure
InChI Key PLHJDBGFXBMTGZ-WEVVVXLNSA-N
Smile O=C1OCCN1/N=C/c1ccc([N+](=O)[O-])o1
InChI
InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H7N3O5
Molecular Weight 225.16
AlogP 0.97
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 3.0
Polar Surface Area 98.18
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 16.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - -
Enzyme Transferase
- - - - 19.33
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -23.98-3.23
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 91.17

Indications

Mesh Heading Maximum Phase Reference
Disease Susceptibility Phase 4 ClinicalTrials
Helicobacter Infections; Infection Phase 4 ClinicalTrials
Gastritis; Stomach Ulcer Phase 4 ClinicalTrials
Dyspepsia; Peptic Ulcer Phase 4 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 67-45-8
ChEBI 5195
ChEMBL CHEMBL1103
DrugBank DB00614
EPA CompTox DTXSID4041997
FDA SRS 5J9CPU3RE0
Human Metabolome Database HMDB14752
KEGG C07999
PubChem 5323714
SureChEMBL SCHEMBL64996
ZINC ZINC000000113418
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