GABAPENTIN ENACARBIL

Search structure
Trade Names:
Synonyms:
Status: Approved (2011)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
UNII: 75OCL1SPBQ

Structure
InChI Key TZDUHAJSIBHXDL-UHFFFAOYSA-N
Smile CC(OC(=O)NCC1(CC(=O)O)CCCCC1)OC(=O)C(C)C
InChI
InChI=1S/C16H27NO6/c1-11(2)14(20)22-12(3)23-15(21)17-10-16(9-13(18)19)7-5-4-6-8-16/h11-12H,4-10H2,1-3H3,(H,17,21)(H,18,19)

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H27NO6
Molecular Weight 329.39
AlogP 2.68
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 101.93
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 23.0

Pharmacology

Action Mechanism of Action Reference
MODULATOR Voltage-gated calcium channel modulator PubMed FDA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Migraine Disorders 2 D008881 ClinicalTrials
Alcoholism 2 D000437 ClinicalTrials
Diabetic Neuropathies 2 D003929 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Injury, poisoning and procedural complications
18.38
General disorders and administration site conditions
17.5
Psychiatric disorders
14.66
Nervous system disorders
14.23
Cardiac disorders
5.63
Gastrointestinal disorders
4.38
Musculoskeletal and connective tissue disorders
4.02
Respiratory, thoracic and mediastinal disorders
3.52
Vascular disorders
3.39
Skin and subcutaneous tissue disorders
3.02

Cross References

Resources Reference
CAS NUMBER 478296-72-9
ChEBI 68840
ChEMBL CHEMBL1628502
DrugBank DB08872
DrugCentral 4177
FDA SRS 75OCL1SPBQ
Guide to Pharmacology 7560
PubChem 9883933
SureChEMBL SCHEMBL25455
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