GUANFACINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1986)
Entry Type: Small molecule
Molecule Category: Salt
UNII: PML56A160O
Parent Compound: GUANFACINE

Structure
InChI Key DGFYECXYGUIODH-UHFFFAOYSA-N
Smile Cl.N=C(N)NC(=O)Cc1c(Cl)cccc1Cl
InChI
InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H10Cl3N3O
Molecular Weight 282.56
AlogP 1.55
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 2.0
Polar Surface Area 78.97
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 15.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Adrenergic receptor alpha-2 agonist DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Attention Deficit Disorder with Hyperactivity 4 D001289 ClinicalTrials

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Psychiatric disorders
23.59
Nervous system disorders
18.66
General disorders and administration site conditions
12.13
Injury, poisoning and procedural complications
8.66
Cardiac disorders
7.39
Vascular disorders
6.16
Investigations
4.85
Gastrointestinal disorders
3.69
Respiratory, thoracic and mediastinal disorders
2.46
Skin and subcutaneous tissue disorders
2.22
Metabolism and nutrition disorders
2.19

Cross References

Resources Reference
ChEBI 5559
ChEMBL CHEMBL1200494
EPA CompTox DTXSID2045157
FDA SRS PML56A160O
KEGG C07037
PubChem 71401
SureChEMBL SCHEMBL41681
ZINC ZINC03872738
CONTENTS