HALOPERIDOL DECANOATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1986)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
UNII: AC20PJ4101

Structure
InChI Key GUTXTARXLVFHDK-UHFFFAOYSA-N
Smile CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1
InChI
InChI=1S/C31H41ClFNO3/c1-2-3-4-5-6-7-8-11-30(36)37-31(26-14-16-27(32)17-15-26)20-23-34(24-21-31)22-9-10-29(35)25-12-18-28(33)19-13-25/h12-19H,2-11,20-24H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C31H41ClFNO3
Molecular Weight 530.12
AlogP 8.12
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 15.0
Polar Surface Area 46.61
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 37.0

Pharmacology

Action Mechanism of Action Reference
INVERSE AGONIST D2-like dopamine receptor inverse agonist ISBN PubMed DailyMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- - - 1-2 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Delirium 2 D003693 ClinicalTrials

Related Entries

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
18.28
Psychiatric disorders
15.47
General disorders and administration site conditions
14.11
Injury, poisoning and procedural complications
11.8
Musculoskeletal and connective tissue disorders
5.63
Investigations
3.65
Gastrointestinal disorders
3.41
Cardiac disorders
3.01
Metabolism and nutrition disorders
2.86
Skin and subcutaneous tissue disorders
2.61
Respiratory, thoracic and mediastinal disorders
2.5
Vascular disorders
2.48
Product issues
2.29

Cross References

Resources Reference
ChEBI 31664
ChEMBL CHEMBL1200986
DrugCentral 4496
EPA CompTox DTXSID50224951
FDA SRS AC20PJ4101
PubChem 52919
SureChEMBL SCHEMBL120575
ZINC ZINC000008214574
CONTENTS