HYDROCORTISONE PROBUTATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1997)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
UNII: O6550D6K3A

Structure
InChI Key FOGXJPFPZOHSQS-AYVLZSQQSA-N
Smile CCCC(=O)O[C@]1(C(=O)COC(=O)CC)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C
InChI
InChI=1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C28H40O7
Molecular Weight 488.62
AlogP 4.09
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 7.0
Polar Surface Area 106.97
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 35.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucocorticoid receptor agonist PubMed PubMed PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Dermatitis, Atopic 4 D003876 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 72590-77-3
ChEBI 31675
ChEMBL CHEMBL1200953
DrugBank DB14543
DrugCentral 4569
EPA CompTox DTXSID3048603
FDA SRS O6550D6K3A
KEGG C13358
PubChem 636398
SureChEMBL SCHEMBL4778
ZINC ZINC000004213519
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