INSULIN HUMAN

Search structure
Trade Names:
Synonyms:
Status: Approved
Entry Type: Protein
Molecule Category: UNKNOWN

Pharmacology

Action Mechanism of Action Reference
AGONIST Insulin receptor agonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase InsR family
- 1.932 - 1.816 -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family
- 18107 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetes Mellitus, Type 2 4 D003924 ClinicalTrials
Myocardial Infarction 3 D009203 ClinicalTrials
Diabetes, Gestational 3 D016640 ClinicalTrials
Hyperglycemia 3 D006943 ClinicalTrials
Hypertension 3 D006973 ClinicalTrials
Atherosclerosis 3 D050197 ClinicalTrials
Coronary Disease 3 D003327 ClinicalTrials
Hypogonadism 3 D007006 ClinicalTrials
Hypercholesterolemia 3 D006937 ClinicalTrials
Depressive Disorder, Major 3 D003865 ClinicalTrials
Hypogonadism 3 D007006 ClinicalTrials
Heart Failure 3 D006333 ClinicalTrials
Diabetes Mellitus, Type 1 3 D003922 ClinicalTrials
Acute Coronary Syndrome 3 D054058 ClinicalTrials
Shock, Septic 3 D012772 ClinicalTrials
Bipolar Disorder 3 D001714 ClinicalTrials
Angina, Unstable 3 D000789 ClinicalTrials
Myocardial Infarction 3 D009203 ClinicalTrials
Insulin Resistance 3 D007333 ClinicalTrials
Premature Birth 2 D047928 ClinicalTrials
Tobacco Use Disorder 2 D014029 ClinicalTrials
Non-alcoholic Fatty Liver Disease 2 D065626 ClinicalTrials
Hypoglycemia 2 D007003 ClinicalTrials
Pain 2 D010146 ClinicalTrials
Diabetic Neuropathies 2 D003929 ClinicalTrials
Acute Kidney Injury 2 D058186 ClinicalTrials
Persian Gulf Syndrome 2 D018923 ClinicalTrials
Stroke 2 D020521 ClinicalTrials
Stress Disorders, Post-Traumatic 2 D013313 ClinicalTrials
Burns 2 D002056 ClinicalTrials
Cognitive Dysfunction 2 D060825 ClinicalTrials
Multiple System Atrophy 2 D019578 ClinicalTrials
Hyperkalemia 2 D006947 ClinicalTrials
Parkinson Disease 2 D010300 ClinicalTrials
Hyperlipidemias 2 D006949 ClinicalTrials
Diabetic Nephropathies 2 D003928 ClinicalTrials
Frontotemporal Dementia 2 D057180 ClinicalTrials
Sarcopenia 1 D055948 ClinicalTrials
Dry Eye Syndromes 1 D015352 ClinicalTrials
Wounds and Injuries 1 D014947 ClinicalTrials
Heart Arrest 1 D006323 ClinicalTrials
Schizophrenia 1 D012559 ClinicalTrials
Multiple Sclerosis, Relapsing-Remitting 1 D020529 ClinicalTrials
Multiple Sclerosis, Chronic Progressive 1 D020528 ClinicalTrials
Glaucoma 1 D005901 ClinicalTrials
Keloid 1 D007627 ClinicalTrials
Severe Acute Respiratory Syndrome 1 D045169 ClinicalTrials
Alcoholism 1 D000437 ClinicalTrials
Hyperinsulinism 1 D006946 ClinicalTrials
Carpal Tunnel Syndrome 1 D002349 ClinicalTrials
Delirium 1 D003693 ClinicalTrials
Ischemic Stroke 1 D000083242 ClinicalTrials
Obesity 1 D009765 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Investigations
16.5
Injury, poisoning and procedural complications
12.36
General disorders and administration site conditions
10.07
Nervous system disorders
9.74
Eye disorders
6.21
Vascular disorders
5.65
Metabolism and nutrition disorders
5.27
Musculoskeletal and connective tissue disorders
4.03
Endocrine disorders
3.96
Psychiatric disorders
3.58
Cardiac disorders
3.46
Skin and subcutaneous tissue disorders
3.2
Gastrointestinal disorders
2.9
Respiratory, thoracic and mediastinal disorders
2.58
Infections and infestations
2.48
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