IPILIMUMAB

Search structure
Trade Names:
Synonyms:
Status: Approved (2011)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L01XC11
UNII: 6T8C155666

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Cytotoxic T-lymphocyte protein 4 inhibitor
Primary Target
cytotoxic T-lymphocyte-associated protein 4 (CD152)

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Mesothelioma, Malignant 4 D000086002 ClinicalTrials
Colorectal Neoplasms 4 D015179 ClinicalTrials
Colorectal Neoplasms 4 D015179 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Melanoma 4 D008545 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Colorectal Neoplasms 4 D015179 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Small Cell Lung Carcinoma 3 D055752 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Urogenital Neoplasms 3 D014565 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Glioblastoma 3 D005909 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Nasopharyngeal Carcinoma 2 D000077274 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Carcinoma, Merkel Cell 2 D015266 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Adenocarcinoma 2 D000230 ClinicalTrials
Sarcoma, Kaposi 2 D012514 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Sarcoma, Synovial 2 D013584 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Inflammatory Breast Neoplasms 2 D058922 ClinicalTrials
Gliosarcoma 2 D018316 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Adenocarcinoma of Lung 2 D000077192 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Liposarcoma 2 D008080 ClinicalTrials
Carcinoma, Basal Cell 2 D002280 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Retroviridae Infections 2 D012192 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Pituitary Neoplasms 2 D010911 ClinicalTrials
Meningioma 2 D008579 ClinicalTrials
Carcinoma, Small Cell 2 D018288 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Basal Cell Nevus Syndrome 2 D001478 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Meningioma 2 D008579 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Leiomyosarcoma 2 D007890 ClinicalTrials
Uveal Melanoma 2 D000098943 ClinicalTrials
Uveal Melanoma 2 D000098943 ClinicalTrials
Neuroendocrine Tumors 2 D018358 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Adenocarcinoma 2 D000230 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Histiocytoma, Malignant Fibrous 2 D051677 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Endometrial Neoplasms 1 D016889 ClinicalTrials
Fallopian Tube Neoplasms 1 D005185 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1 D015464 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials
Neuroblastoma 1 D009447 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 1 D016403 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Retroperitoneal Neoplasms 1 D012186 ClinicalTrials
Myelodysplastic Syndromes 1 D009190 ClinicalTrials
Peritoneal Neoplasms 1 D010534 ClinicalTrials
Lymphoma, Follicular 1 D008224 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Endometrial Neoplasms 1 D016889 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 1 D015451 ClinicalTrials
Leukemia, Myeloid 1 D007951 ClinicalTrials
Cholangiocarcinoma 1 D018281 ClinicalTrials
Multiple Myeloma 1 D009101 ClinicalTrials
HIV Infections 1 D015658 ClinicalTrials
Triple Negative Breast Neoplasms 1 D064726 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Carcinoma, Pancreatic Ductal 1 D021441 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Nerve Sheath Neoplasms 1 D018317 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Skin Neoplasms 1 D012878 ClinicalTrials
Lymphoma 1 D008223 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Gastrointestinal disorders
13.68
General disorders and administration site conditions
11.65
Endocrine disorders
6.98
Metabolism and nutrition disorders
6.68
Skin and subcutaneous tissue disorders
5.92
Nervous system disorders
5.85
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
5.21
Respiratory, thoracic and mediastinal disorders
5.1
Injury, poisoning and procedural complications
5.1
Investigations
4.73
Infections and infestations
4.48
Immune system disorders
4.02
Vascular disorders
3.88
Cardiac disorders
2.97
Hepatobiliary disorders
2.91
Musculoskeletal and connective tissue disorders
2.81

Cross References

Resources Reference
CAS NUMBER 477202-00-9
ChEMBL CHEMBL1789844
FDA SRS 6T8C155666
Guide to Pharmacology 6888
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