ISOPROPAMIDE IODIDE

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Trade Names:	DARBID
Synonyms:	Darbid Dipramid Dipramide Isamid Isopropamide (as iodide) Isopropamide iodide Isoproponum iodide Marygin-m NSC-15521 Piaccamide Priamide Priazimide Sanulcin SKF-4740 Tyrimide
Status:	Approved (1957)
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	E0KNA372SZ

Structure


InChI Key	BFSMWENDZZIWPW-UHFFFAOYSA-N
Smile	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C.[I-]
InChI	InChI=1S/C23H32N2O.HI/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21;/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26);1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H33IN2O
Molecular Weight	480.43
AlogP	4.11
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	8.0
Polar Surface Area	43.09
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	26.0

Pharmacology

Action	Mechanism of Action	Reference
ANTAGONIST	Muscarinic acetylcholine receptor M1 antagonist	ISBN PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	83

Cross References

Resources	Reference
ChEBI	6044
ChEMBL	CHEMBL1200347
EPA CompTox	DTXSID30221221
FDA SRS	E0KNA372SZ
PubChem	6284
SureChEMBL	SCHEMBL100255

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