ISOSORBIDE MONONITRATE

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Trade Names:	IMDUR ISMO ISOSORBIDE MONONITRATE MONOKET
Synonyms:	1,1-diureidisobutane AHR-4698 Angeze 10 Angeze 20 Angeze 40 Angeze sr 40 Angeze sr 60 Angitate Astrodur mr BM 22.145 BM-22-145 BM-22.145 BM-22145 BM 22.145IS 5-MNAHR-4698 Carmil xl Chemydur 60 xl Cibral 10 Cibral 20 Cibral 40 Cibral xl 60 Corangin Diluted isosorbide mononitrate Dynamin Dynamin xl 25 Dynamin xl 50 Elantan 10 Elantan 20 Elantan 40 Elantan la 25 Elantan la 50 Eumon 40 xl Eumon 60 xl Imdur Imo la IS 5-MN IS-5-MN IS-5MN Isib 20 Isib 40 Isib 50 xl Isib 60 xl Ismo Ismo 10 Ismo 20 Ismo 40 Ismo ret Iso-5-mononitrate Isobutyldiurea Isobutylenediurea Isodur Isodur 25 xl Isodur 50 xl Isosorbide 5-mononitrate Isosorbide-5-mononitrate Isosorbide 5-nitrate Isosorbide dinitrate isosorbide-5-mononitrate Isosorbide mononitrate Isotard 25 xl Isotard 40 xl Isotard 50 xl Isotard 60 xl Isotrate Ketanodur Mcr 50 Modisal 40 xl Modisal 60 xl Modisal la 25 Modisal la 50 Monigen xl 60 Monit Monit ls Monit sr Monit xl 60 Mono-cedocard 10 Mono-cedocard 20 Mono-cedocard 40 Monocord Monodur Monoket Monomax sr 40 Monomax sr 60 Monomax xl Monomil xl Monosorb xl 60 NSC-758619 Pertil ret Phasonit la 50 Relosorb xl Slomon xl 60 Tardisc xl Tenkosorb Trangina xl Vasotrate 60 sr Xismox xl 60 Zemon 40 xl Zemon 60 xl Ziotan xl
Status:	Approved (1991)
Entry Type:	Small molecule
Molecule Category:	Parent
ATC:	C01DA14
UNII:	LX1OH63030
Parent Compound:	ISOSORBIDE

Structure


InChI Key	YWXYYJSYQOXTPL-SLPGGIOYSA-N
Smile	O=[N+]([O-])O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@H]12
InChI	InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C6H9NO6
Molecular Weight	191.14
AlogP	-1.28
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	91.06
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	13.0

Pharmacology

Action	Mechanism of Action	Reference
ACTIVATOR	Soluble guanylate cyclase activator	FDA ISBN

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Coronary Disease	4	D003327	ClinicalTrials
Fetal Membranes, Premature Rupture	3	D005322	ClinicalTrials
Hypertension	2	D006973	ClinicalTrials
Heart Failure	2	D006333	ClinicalTrials
Stroke	2	D020521	ClinicalTrials
Oligohydramnios	2	D016104	ClinicalTrials
Vascular Diseases	1	D014652	ClinicalTrials
Fissure in Ano	1	D005401	ClinicalTrials

Related Entries

Scaffolds

Target Level :

Level 3

Level 4

Level 5

Level 6

Extend network:

Indication

Mechanism of Action

Primary Target

Target Level

Parent

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
Nervous system disorders	15.38
Vascular disorders	14.72
Cardiac disorders	13.62
General disorders and administration site conditions	9.67
Injury, poisoning and procedural complications	8.61
Gastrointestinal disorders	5.58
Skin and subcutaneous tissue disorders	5.49
Respiratory, thoracic and mediastinal disorders	3.78
Musculoskeletal and connective tissue disorders	3.73
Psychiatric disorders	3.38
Investigations	2.72
Immune system disorders	2.55

Cross References

Resources	Reference
CAS NUMBER	16051-77-7
ChEBI	6062
ChEMBL	CHEMBL1311
DrugBank	DB01020
DrugCentral	1506
EPA CompTox	DTXSID9023176
FDA SRS	LX1OH63030
Human Metabolome Database	HMDB0015155
Guide to Pharmacology	7052
KEGG	C07714
PharmGKB	PA450126
PubChem	27661
SureChEMBL	SCHEMBL26781
ZINC	ZINC000001849548

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